Maternal Depressive Symptoms During and After Pregnancy and Psychiatric Problems in Children

Lahti, Marius; Savolainen, Katri; Tuovinen, Soile; Pesonen, Anu‐Katriina; Lahti, Jari; Heinonen, Kati; Hämäläinen, Esa; Laivuori, Hannele; Villa, Pia; Reynolds, Rebecca M.; Kajantie, Eero; Räikkönen, Katri

doi:10.1016/j.jaac.2016.10.007

Cited by 123 publications

(153 citation statements)

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“…The adverse outcomes include prematurity 2 and increased risks of poorer cognition and psychiatric problems later in life. 1,3–5 Findings from these studies are compatible with the Developmental Origins of Health and Disease (DOHaD) framework, which suggests that in utero exposure to environmental adversities may alter the structure and function of developing cells, tissues, organs, and physiological feedback systems, leading to individual differences in aging and disease trajectories that persist throughout the lifespan. 3 …”

supporting

confidence: 56%

“…8,25,26 That lower epigenetic age might indicate such an increased risk is, however, congruent with the DOHaD concept: the risk for aging-related diseases and mental problems is increased in individuals exposed to prenatal environmental adversities, which are associated with lower birth weight, lower GA, and maternal depression during pregnancy. 1,2 Because DNA methylation has been shown to undergo age-related changes, 27 it remains possible that both lower and higher epigenetic GA signal risk. This risk may, however, depend on life stage.…”

Section: Discussionmentioning

confidence: 99%

“…1 Depression not only hinders the health and well-being of the pregnant mother, but is also associated with adverse perinatal and developmental outcomes in her child. The adverse outcomes include prematurity 2 and increased risks of poorer cognition and psychiatric problems later in life.…”

mentioning

confidence: 99%

“…The current study sought to determine whether maternal history of depression diagnosed before pregnancy and antenatal depressive symptoms were related to the child’s epigenetic GA at birth based on fetal cord blood DNAm data. We also tested whether these conditions exerted additive effects on child’s epigenetic GA, as not all individuals with a history of depression diagnosis report high antenatal depressive symptoms and vice versa, 1 and whether the effects of antenatal depressive symptoms were gestation-stage specific. Furthermore, we tested whether child’s epigenetic GA at birth predicted early childhood psychiatric problems, and whether child’s epigenetic GA mediated the associations of maternal antenatal depression with child psychiatric problems.…”

mentioning

confidence: 99%

“…Finally, we tested whether the associations were moderated by child’s sex, as sex biases exist in longevity and aging trajectories, 12 epigenetic age based on the Horvath and the Hannum epigenetic age predictors, 6,9 epigenetic GA at birth, 11 and prevalence and etiology of psychiatric problems. 1,3–5,13 . The effects of maternal stress exposure during pregnancy 3–5,14 and particularly antenatal depression 4 on offspring developmental outcomes, have also shown sex specificity.…”

mentioning

confidence: 99%

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The Epigenetic Clock at Birth: Associations With Maternal Antenatal Depression and Child Psychiatric Problems

Suarez

Lahti

Czamara

et al. 2018

Journal of the American Academy of Child & Adolescent Psych

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Objective: Maternal antenatal depression may compromise the fetal developmental milieu and contribute to individual differences in aging and disease trajectories in later life. We evaluated the association between maternal antenatal depression and a novel biomarker of aging at birth, namely epigenetic gestational age (GA) based on fetal cord blood methylation data. We also examined whether this biomarker prospectively predicts and mediates maternal effects on early childhood psychiatric problems. Method: A total of 694 mothers from the Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) Study provided information on history of depression diagnosed before pregnancy; 581 completed the Center for Epidemiological Studies Depression Scale throughout pregnancy, and 407 completed the Child Behavior Checklist at child’s age 3.7 years (SD = 0.75 year). DNA methylation (DNAm) GA of fetal cord blood DNA was based on the methylation profile of 148 selected cytosine linked to guanine by phosphate (CpG) sites. Epigenetic GA was calculated as the arithmetic difference between DNAm GA and chronological GA and adjusted for chronological GA. Results: Maternal history of depression diagnosed before pregnancy (mean difference = –0.25 SD units, 95% CI = –0.46 to 0.03) and greater antenatal depressive symptoms (–0.08 SD unit per 1-SD unit increase, 95% CI = –0.16 to –0.004) were associated with child’s lower epigenetic GA. Child’s lower epigenetic GA, in turn, prospectively predicted total and internalizing problems and partially mediated the effects of maternal antenatal depression on internalizing problems in boys. Conclusion: Maternal antenatal depression is associated with lower epigenetic GA in offspring. This lower epigenetic GA seems to be associated with a developmental disadvantage for boys, who, in early childhood, show greater psychiatric problems.

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supporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The Epigenetic Clock at Birth: Associations With Maternal Antenatal Depression and Child Psychiatric Problems

Suarez

Lahti

Czamara

et al. 2018

Journal of the American Academy of Child & Adolescent Psych

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Maternal depressive symptoms during and after pregnancy and child developmental milestones

et al. 2018

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Maternal depressive symptoms during pregnancy, in the first year postpartum and in early childhood are associated with poorer child neurodevelopment. Our findings further suggest that antenatal and postpregnancy depression have additive effects on neurodevelopment. Children of mothers with the most chronic and severe depressive symptoms during pregnancy had the most neurodevelopmental disadvantages. Our findings emphasize the adverse effects of maternal depression during and after pregnancy and in early childhood on child neurodevelopment.

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Polygenic prediction of the risk of perinatal depressive symptoms

Rantalainen

Binder

Lahti‐Pulkkinen

et al. 2020

Depression and Anxiety

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Background Perinatal depression carries adverse effects on maternal health and child development, but genetic underpinnings remain unclear. We investigated the polygenic risk of perinatal depressive symptoms. Methods About 742 women from the prospective Prediction and Prevention of Pre‐eclampsia and Intrauterine Growth Restriction cohort were genotyped and completed the Center for Epidemiologic Studies Depression scale 14 times during the prenatal period and twice up to 12 months postpartum. Polygenic risk scores for major depressive disorder, bipolar disorder, schizophrenia, and cross‐disorder were calculated using multiple p‐value thresholds. Results Polygenic risk scores for major depressive disorder, schizophrenia, and cross‐disorder, but not bipolar disorder, were associated with higher prenatal and postpartum depressive symptoms (0.8%–1% increase per one standard deviation increase in polygenic risk scores). Prenatal depressive symptoms accounted for and mediated the associations between the polygenic risk scores and postpartum depressive symptoms (effect size proportions‐mediated: 52.2%–88.0%). Further, the polygenic risk scores were associated with 1.24–1.45‐fold odds to belong to the group displaying consistently high compared with consistently low depressive symptoms through out the prenatal and postpartum periods. Conclusions Polygenic risk scores for major depressive disorder, schizophrenia, and cross‐disorder in non‐perinatal populations generalize to perinatal depressive symptoms and may afford to identify women for timely preventive interventions.

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Maternal Depressive Symptoms During and After Pregnancy and Psychiatric Problems in Children

Cited by 123 publications

References 37 publications

The Epigenetic Clock at Birth: Associations With Maternal Antenatal Depression and Child Psychiatric Problems

The Epigenetic Clock at Birth: Associations With Maternal Antenatal Depression and Child Psychiatric Problems

Maternal depressive symptoms during and after pregnancy and child developmental milestones

Polygenic prediction of the risk of perinatal depressive symptoms

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