Maternal Deprivation Induces Depressive-like Behaviour and Alters Neurotrophin Levels in the Rat Brain

Réus, Gislaine Z.; Stringari, Roberto B.; Ribeiro, Karine F.; Cipriano, Andreza L.; Panizzutti, Bruna; Stertz, Laura; Lersch, C.; Kapczinski, Flávio; Quevedo, João

doi:10.1007/s11064-010-0364-3

Cited by 92 publications

(61 citation statements)

References 57 publications

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“…22,23 In contrast, treatment with antidepressants in animals deprived of maternal care was able to reverse depressive-type behaviors, promoting an increase in neurotrophin levels and neurogenesis. 2 …”

Section: Maternal Deprivationmentioning

confidence: 99%

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Animal models as tools to study the pathophysiology of depression

Abelaira

Réus

Quevedo

2013

Rev. Bras. Psiquiatr.

199

116

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The incidence of depressive illness is high worldwide, and the inadequacy of currently available drug treatments contributes to the significant health burden associated with depression. A basic understanding of the underlying disease processes in depression is lacking; therefore, recreating the disease in animal models is not possible. Popular current models of depression creatively merge ethologically valid behavioral assays with the latest technological advances in molecular biology. Within this context, this study aims to evaluate animal models of depression and determine which has the best face, construct, and predictive validity. These models differ in the degree to which they produce features that resemble a depressive-like state, and models that include stress exposure are widely used. Paradigms that employ acute or sub-chronic stress exposure include learned helplessness, the forced swimming test, the tail suspension test, maternal deprivation, chronic mild stress, and sleep deprivation, to name but a few, all of which employ relatively short-term exposure to inescapable or uncontrollable stress and can reliably detect antidepressant drug response.

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Section: Maternal Deprivationmentioning

confidence: 99%

“…83 Besides the effects of antidepressant drugs, the FST can also be used to evaluate the type of depressive behavior; for example, it has been demonstrated that animals subjected to a protocol of maternal deprivation exhibit increased immobility time in the FST. 23 …”

Section: Forced Swimming Testmentioning

confidence: 99%

Animal models as tools to study the pathophysiology of depression

Abelaira

Réus

Quevedo

2013

Rev. Bras. Psiquiatr.

199

116

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“…Growth factors have also been implicated in depression [66], as depression-like behavior has been associated with reduced NGF and IGF1 levels in the rat brain [67,68]. Altered NGF levels have been shown to increase the risk of developing depression after chronic stress [69], while 19 antidepressant drugs have been shown to have a beneficial impact of on the malfunction of IGF1 in adult rats [70].…”

Section: Common Regulators and Targets Of The Maternally Altered Protmentioning

confidence: 99%

Maternal alterations in the proteome of the medial prefrontal cortex in rat

Völgyi

Udvari²,

Szabó³

et al. 2017

Journal of Proteomics

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Proteomic differences between rat dams and control mothers deprived of their pups immediately after delivery were investigated in the medial prefrontal cortex (mPFC).A 2-D DIGE minimal dye technique combined with LC-MS/MS identified 32 different proteins that showed significant changes in expression in the mPFC, of which, 25were upregulated and 7 were downregulated in dams. The identity of one significantly increased protein, the small heat-shock protein alpha-crystallin B chain (Cryab), was confirmed via Western blot analysis. Alpha-crystallin B chain was distributed in scattered cells in the mPFC, as demonstrated by immunohistochemistry. Furthermore, it was found to be localized in parvalbumin-containing neurons using double labeling. The elevation of its mRNA level in rat dams was also demonstrated via RT-PCR.The functional classification of the altered proteins was conducted using the UniProt and Gene Ontology protein databases. The identified proteins predominantly participate in synaptic transport and plasticity, neuron development, oxidative stress and apoptosis, and cytoskeleton organization. A common regulator and target analysis of these proteins determined using the Elsevier Pathway Studio Platform suggests that protein level changes associated with pup nursing are driven by growth factors and cytokines, while the MAP kinase pathway was identified as a common target. A high proportion of the proteins that were found to be altered in the mPFC are associated with depression. Biological significanceThe behavior and emotional state of females change robustly when they become mothers. The brain, which governs these changes, may also undergo molecular alterations in mothers. As no proteomics approaches have been applied regarding maternal changes in the brain, we addressed this issue in the mPFC as this brain area is the uppermost cortical center Alpha-crystallin B chain, a protein confirmed to be increased during maternal behaviors, was selectively found in parvalbumin cells, which, as fast-spiking interneurons, are associated with depression. The function of alpha-crystallin B chain should be further investigated to establish whether it can be used to identify drug targets for future drug development.

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“…12,35 Preclinical models of depression based on induction of chronic or acute stress, such as unpredictable chronic mild stress, early life stress (maternal deprivation), and restraint stress, are important to replicate etiological conditions of depression. [36][37][38][39][40][41][42] Animal models based on unpredictable chronic mild stress, 38,40,41,43,44 maternal deprivation, [45][46][47][48] and restraint stress 36,49 (different duration and stimuli type of stressful events) induce HPA axis hyperactivity. HPA axis hyperactivity is closely related to stressful life events, which are key factors in the etiopathogenesis of depressive episodes in patients.…”

Section: Animal Models Of Depressionmentioning

confidence: 99%

“…40,55 The maternal deprivation-or restraint stress-induced animal models of depression have also been associated with elevated plasma levels of corticosterone and/or ACTH (adrenocorticotropin hormone). [45][46][47][48][49] The induction of stress in animals can cause remodeling of synaptic contacts on CRH neurons, contributing to the development of animal models of stress-related psychiatric disorders such as depression. 56 The administration of classical antidepressants reverses stress-induced biochemical and behavioral changes.…”

Section: Animal Models Of Depressionmentioning

confidence: 99%

Contributions of animal models to the study of mood disorders

Valvassori

Budni

Varela

et al. 2013

Rev. Bras. Psiquiatr.

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Mood disorders are a leading cause of morbidity and mortality, yet their underlying pathophysiology remains unclear. Animal models serve as a powerful tool for investigating the neurobiological mechanisms underlying psychiatric disorders; however, no animal model developed to date can fully mimic the ''corresponding'' human psychiatric disorder. In this scenario, the development of different animal models contributes to our understanding of the neurobiology of these disorders and provides the possibility of preclinical pharmacologic screening. The present review seeks to provide a comprehensive overview of traditional and recent animal models, recapitulating different features and the possible pathologic mechanisms of mood disorders emulated by these models.

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Maternal Deprivation Induces Depressive-like Behaviour and Alters Neurotrophin Levels in the Rat Brain

Cited by 92 publications

References 57 publications

Animal models as tools to study the pathophysiology of depression

Animal models as tools to study the pathophysiology of depression

Maternal alterations in the proteome of the medial prefrontal cortex in rat

Contributions of animal models to the study of mood disorders

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