Maternal Diet Quality during Pregnancy and Allergic and Respiratory Multimorbidity Clusters in Children from the EDEN Mother–Child Cohort

Delvert, Rosalie; Ghozal, Manel; Adel‐Patient, Karine; Kadawathagedara, Manik; Heude, Barbara; Charles, Marie‐Aline; Annesi‐Maesano, Isabella; Tafflet, Muriel; Leynaert, Bénédicte; Varraso, Raphäelle; Lauzon-Guillain, Blandine de; Bédard, Annabelle

doi:10.3390/nu15010146

Cited by 8 publications

(5 citation statements)

References 54 publications

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“…Then, negative associations could be explained by the potential beneficial effect of high intake of fruit and vegetable on asthma, as reported in general population [ 26 ]. However, the protective effect of fruit consumption during pregnancy on asthma and respiratory events in offspring is not well established [ 17 ]. Moreover, in our study the mixture composed by perfluoroalkyl acids, PAHs and trace elements was not strongly correlated with any individual food item.…”

Section: Discussionmentioning

confidence: 99%

Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort

Ghozal,

Kadawathagedara,

Delvert

et al. 2024

Environ Health

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Introduction Prenatal exposure to environmental chemicals may be associated with allergies later in life. We aimed to examine the association between prenatal dietary exposure to mixtures of chemicals and allergic or respiratory diseases up to age 5.5 y. Methods We included 11,638 mother-child pairs from the French “Étude Longitudinale Française depuis l’Enfance” (ELFE) cohort. Maternal dietary exposure during pregnancy to eight mixtures of chemicals was previously assessed. Allergic and respiratory diseases (eczema, food allergy, wheezing and asthma) were reported by parents between birth and age 5.5 years. Associations were evaluated with adjusted logistic regressions. Results are expressed as odds ratio (OR[95%CI]) for a variation of one SD increase in mixture pattern. Results Maternal dietary exposure to a mixture composed mainly of trace elements, furans and polycyclic aromatic hydrocarbons (PAHs) was positively associated with the risk of eczema (1.10 [1.05; 1.15]), this association was consistent across sensitivity analyses. Dietary exposure to one mixture of pesticides was positively associated with the risk of food allergy (1.10 [1.02; 1.18]), whereas the exposure to another mixture of pesticides was positively but slightly related to the risk of wheezing (1.05 [1.01; 1.08]). This last association was not found in all sensitivity analyses. Dietary exposure to a mixture composed by perfluoroalkyl acids, PAHs and trace elements was negatively associated with the risk of asthma (0.89 [0.80; 0.99]), this association was consistent across sensitivity analyses, except the complete-case analysis. Conclusion Whereas few individual chemicals were related to the risk of allergic and respiratory diseases, some consistent associations were found between prenatal dietary exposure to some mixtures of chemicals and the risk of allergic or respiratory diseases. The positive association between trace elements, furans and PAHs and the risk of eczema, and that between pesticides mixtures and food allergy need to be confirmed in other studies. Conversely, the negative association between perfluoroalkyl acids, PAHs and trace elements and the risk of asthma need to be further explored.

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Section: Discussionmentioning

confidence: 99%

Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort

Ghozal,

Kadawathagedara,

Delvert

et al. 2024

Environ Health

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“…Willers et al found that maternal apple intake during pregnancy was associated with lower wheezing and asthma among offspring at ve years old [8]. Another study found that children born to mothers who consumed legumes once a month or less were at a heightened risk of belonging to the 'multi-allergic' cluster, suggesting a potential role for legume consumption in preventing allergic diseases [30]. A third study observed an association between maternal intake of peanuts and tree nuts and the prevalence of asthma in 18-month-old toddlers [31].…”

Section: Discussionmentioning

confidence: 99%

Avocado consumption during pregnancy is associated with child's lower food allergy risk in the prospective KuBiCo study

Cheng,

Bauer,

Ford

et al. 2024

Preprint

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Background Maternal exposures (e.g., nutrition) during pregnancy play a critical role in offspring's health outcomes. Certain nutrients found in avocados have been associated with lower allergic health outcomes in children when consumed during pregnancy, but no study has examined this association. Thus, this study aimed to investigate how maternal avocado consumption during pregnancy relates to offspring allergic health outcomes using the Kuopio Birth Cohort (KuBiCo) Study. Methods This prospective cohort study used data from KuBiCo. Avocado consumption was assessed using an online food frequency questionnaire in trimesters (T) 1 and 3. Avocado consumers were defined as participants who reported consuming any avocado (> 0 grams) in T1 and/or 3, and avocado non-consumers were defined as those who didn’t report consuming any avocado (0 grams) in both T1 and 3. The 12-month follow-up questionnaire captured offspring allergic outcomes (rhinitis, paroxysmal wheezing, atopic eczema, and food allergy). Results Of 4,647 participants, 2,272 met the criteria and were included in the analysis. Compared to avocado non-consumers (during pregnancy), avocado consumers (during pregnancy) had 43.6% lower odds of reporting food allergy among their children at the 12-month follow-up questionnaire while adjusted for relevant covariates. No significant associations were noted in the other three allergic health outcomes in the fully adjusted model. Conclusions Avocado consumption during pregnancy was associated with lower odds of infant food allergies at 12 months, even when accounting for potential covariates.

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“…Consumption of specific foods during pregnancy has been linked to the development of atopic conditions [ 74 ], yet these studies have failed to establish such a link to food allergy development. Greater maternal consumption of processed foods during pregnancy has been correlated with increased food allergy in infants [ 75 , 76 ].…”

Section: Dietary Factors In Allergic Diseasementioning

confidence: 99%

Redefining the Role of Nutrition in Infant Food Allergy Prevention: A Narrative Review

Brandwein,

Enten Vissoker,

Jackson

et al. 2024

Nutrients

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Pediatric food allergy remains commonplace, despite the advancement in our understanding of risk factors and prevention modalities for the condition. Early allergen introduction, a dietary intervention, has been endorsed by professional societies globally as an effective primary preventive measure, yet awareness among medical professionals and parents is lacking. Alongside food allergen introduction, overall nutrition, such as diet diversity, also plays an important role in allergy prevention. To address both food allergen introduction and overall nutrition, dietitians play a pivotal role in the dissemination and education of current guidelines to caregivers. This review addresses the particular role of the dietitian in food allergy prevention consultations, providing up-to-date information on food allergies, their development and prevalence, risk factors, dietary factors and an overview of the current guidelines in the United States. This has not been addressed in any of the current food allergy or nutrition guidelines.

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Maternal Diet Quality during Pregnancy and Allergic and Respiratory Multimorbidity Clusters in Children from the EDEN Mother–Child Cohort

Cited by 8 publications

References 54 publications

Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort

Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort

Avocado consumption during pregnancy is associated with child's lower food allergy risk in the prospective KuBiCo study

Redefining the Role of Nutrition in Infant Food Allergy Prevention: A Narrative Review

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