Maternal Dietary Exposure to Low-Dose Bisphenol A Affects Metabolic and Signaling Pathways in the Brain of Rat Fetuses

Tonini, Claudia; Segatto, Marco; Gagliardi, Simone; Bertoli, Simona; Barberio, Laura; Mandalà, Maurizio; Pallottini, Valentina

doi:10.3390/nu12051448

Cited by 22 publications

(18 citation statements)

References 52 publications

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“…The administration of BPA also reduced synaptic plasticity and diminished expression of NR1, NR2A, NR2B, GluR1, and ERβ in male mice and rat hippocampus, leading to impairment of learning and memory [144,48,57,145]. The exposure of pregnant female Sprague Dawley rats to a very low dose of BPA (2.5 µg/kg/day) impacted on ER-α phosphorylation in a sex-dependent manner, especially male fetuses [146], resulting in decreasing the BDNF levels [147]. In addition, other studies have shown that BPA treatment signi cantly decreased BDNF level [148,149].…”

Section: Discussionmentioning

confidence: 98%

Potential Neuroprotective Effect of Nanomicelle Curcumin on Learning and Memory Functions Following Subacute Exposure to Bisphenol a in Adult Male Rats

Fallahnezhad

Ghorbani-Taherdehi

Nadim

et al. 2021

Preprint

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ObjectiveBisphenol A (BPA) is an endocrine-disrupting chemical that widely used in plastics production. It can influence on the brain tissue. Curcumin has a strong protective activity against brain disorders. The purpose of this study was to evaluate the protective effect of nanomicelle curcumin (NmCur) on BPA-induced learning and memory disorders in rats.Material and methodsIn this study, after determining the dose of BPA, rats were randomly divided into 8 groups (8 rats in each group); sesame oil, dextrose 5%, sesame oil + dextrose 5%, NmCur (50 mg/kg), BPA (50 mg/kg), and 50 mg/kg BPA plus 10, 25, or 50 mg/kg NmCur, respectively. All materials administered via gavage. Behavioral tests were estimated by shuttle-box, open-field, and Morris water maze devices. Then, stress oxidative, pro-inflammatory cytokines, oxidative stress-scavenging enzymes levels, as well as expression of MAPK proteins, glutamate receptors, and memory-related proteins were determined in the hippocampus and cortex tissues. ResultsBPA significantly increased expression of ROS, MDA, TNF-α, IL-6, IL-1β, SOD, GST, p-P38, and p-JNK; however, considerably decreased GSH, GPx, GR, CAT, p-AKT, p-ERK1/2 levels. In addition, it down regulated expression of p-NR1, p-NR2A, p-NR2B, p-GluA1, BDNF, and p-CREB in rat cortex and hippocampus tissues. BPA significantly also changed behavioral activity. Conversely, BPA (50 mg/kg) plus NmCur (25 and 50 mg/kg) significantly reversed all BPA-induced adverse effects. ConclusionThe results of this study support that nanomicelle curcumin exhibited preventive effects against neurotoxicity and learning and memory impairment induced by subacute exposure to bisphenol A.

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Section: Discussionmentioning

confidence: 98%

Potential Neuroprotective Effect of Nanomicelle Curcumin on Learning and Memory Functions Following Subacute Exposure to Bisphenol a in Adult Male Rats

Fallahnezhad

Ghorbani-Taherdehi

Nadim

et al. 2021

Preprint

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“…Noteworthily, the urinary concentrations of BPA and phthalate metabolites in our study were far below the reference HBM values for the general population estimated by biomonitoring data. However, some recent studies in rat fetuses [69,70] have shown that maternal exposure to very low doses of BPA (2.5 µg/kg/day) was able to alter hepatic lipid metabolism and metabolic pathways important for the proper development and functioning of the brain. Furthermore, other studies [71,72] have shown that gestational exposure to BPA at low doses was able to cause cognitive deficits and influence the development of circadian centers in the offspring of rats and mice.…”

Section: Discussionmentioning

confidence: 99%

Lifestyle Habits and Exposure to BPA and Phthalates in Women of Childbearing Age from Northern Italy: A Pilot Study

Napoli

Tagliaferri

Sommella

et al. 2021

IJERPH

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Background: Endocrine-disrupting chemicals (EDCs) are compounds that interfere with aspects of hormonal signaling. Considerable attention has been paid to their biological effects especially in women of childbearing age or during pregnancy as EDCs have been reported to cross the placenta becoming concentrated in the fetus’ circulation. Lifestyle habits, daily consumption of packaged foods and use of healthcare/cosmetic products are associated with increased EDCs levels. This cross-sectional research examined the EDCs levels and the lifestyle determinants of EDC exposure in a cohort of reproductive-age women from Northern Italy. Methods: Forty-five women (median age: 36, IQR: 30–38) were evaluated for urinary bisphenol A (BPA) and phthalates levels and also studied for EDCs’ major determinants of daily exposure; food frequency/dietary, physical activity, smoking habits and weight status. Results: Although 100% of women seemed to have been exposed to common sources of EDCs, they reported a healthy lifestyle. The multivariable model described a positive and significant association between consumption of sauces/dressings in plastic containers and monoethyl phthalate exposure (p = 0.037). Conclusions: Since reproductive age encompasses a critical window for future health and functioning of the “mothers-to-be” and their children, future studies on prenatal dietary BPA and phthalate exposure and the role of consumer product choices in reducing such exposure are recommended.

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“…In a study by Timms et al, 2005, showing that pregnant mice exposed to 0.25 µg/kg/day of BPA had disturbed mammary gland growth, postnatal growth, and rate of sexual maturation [25]. Similarly, in a different study, rats exposed to a low dose of BPA (2.5 µg/kg/day) in utero had changes in the mevalonate pathway and a reduction in the neurotrophic precursor brain derived neurotrophic factor (pro-BDNF), which is implicated in brain development and function [26]. The levels of BPA found in humans often depend on various factors such as sample type (serum, tissue, etc.).…”

Section: Exposure Absorption and Metabolismmentioning

confidence: 96%

Bisphenols and the Development of Type 2 Diabetes: The Role of the Skeletal Muscle and Adipose Tissue

2021

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Bisphenol A (BPA) and bisphenol S (BPS) are environmental contaminants that have been associated with the development of insulin resistance and type 2 diabetes (T2D). Two organs that are often implicated in the development of insulin resistance are the skeletal muscle and the adipose tissue, however, seldom studies have investigated the effects of bisphenols on their metabolism. In this review we discuss metabolic perturbations that occur in both the skeletal muscle and adipose tissue affected with insulin resistance, and how exposure to BPA or BPS has been linked to these changes. Furthermore, we highlight the possible effects of BPA on the cross-talk between the skeletal muscle and adipose tissue.

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Maternal Dietary Exposure to Low-Dose Bisphenol A Affects Metabolic and Signaling Pathways in the Brain of Rat Fetuses

Cited by 22 publications

References 52 publications

Potential Neuroprotective Effect of Nanomicelle Curcumin on Learning and Memory Functions Following Subacute Exposure to Bisphenol a in Adult Male Rats

Potential Neuroprotective Effect of Nanomicelle Curcumin on Learning and Memory Functions Following Subacute Exposure to Bisphenol a in Adult Male Rats

Lifestyle Habits and Exposure to BPA and Phthalates in Women of Childbearing Age from Northern Italy: A Pilot Study

Bisphenols and the Development of Type 2 Diabetes: The Role of the Skeletal Muscle and Adipose Tissue

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