Maternal dietary restriction during lactation influences postnatal growth and behavior in the offspring of mice

Kumon, Mami; Yamamoto, Kazuhiro; Takahashi, Akio; Wada, Keiji; Wada, Etsuko

doi:10.1016/j.neuint.2010.04.009

Cited by 9 publications

(5 citation statements)

References 38 publications

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“…Decreased maternal nutrient delivery to the fetus results in impaired fetal development and subsequent postnatal developmental problems ( 1 ) . Several models of decreased maternal nutrition ( 2 , 3 ) including protein restriction ( 4 – 6 ) have been studied in attempts to understand developmental programming – the process through which nutritional or other challenges during a critical window of fetal or neonatal development elicit persistent responses that produce long-term changes in offspring phenotype ( 7 ) . There is compelling evidence that developmental programming results from poor maternal nutrition from human epidemiological ( 8 – 10 ) and animal studies ( 5 , 11 – 13 ) , where the variation in nutrient supply during early development appears to be a strong signal initiating adaptive developmental processes ( 14 ) .…”

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confidence: 99%

Sugared water consumption by adult offspring of mothers fed a protein-restricted diet during pregnancy results in increased offspring adiposity: the second hit effect

et al. 2013

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Poor maternal nutrition predisposes offspring to metabolic disease. This predisposition is modified by various postnatal factors. We hypothesised that coupled to the initial effects of developmental programming due to a maternal low-protein diet, a second hit resulting from increased offspring postnatal sugar consumption would lead to additional changes in metabolism and adipose tissue function. The objective of the present study was to determine the effects of sugared water consumption (5 % sucrose in the drinking-water) on adult offspring adiposity as a 'second hit' following exposure to maternal protein restriction during pregnancy. We studied four offspring groups: (1) offspring of mothers fed the control diet (C); (2) offspring of mothers fed the restricted protein diet (R); (3) offspring of control mothers that drank sugared water (C-S); (4) offspring of restricted mothers that drank sugared water (R-S). Maternal diet in pregnancy was considered the first factor and sugared water consumption as the second factor -the second hit. Body weight and total energy consumption, before and after sugared water consumption, were similar in all the groups. Sugared water consumption increased TAG, insulin and cholesterol concentrations in both the sexes of the C-S and R-S offspring. Sugared water consumption increased leptin concentrations in the R-S females and males but not in the R offspring. There was also an interaction between sugared water and maternal diet in males. Sugared water consumption increased adipocyte size and adiposity index in both females and males, but the interaction with maternal diet was observed only in females. Adiposity index and plasma leptin concentrations were positively correlated in both the sexes. The present study shows that a second hit during adulthood can amplify the effects of higher adiposity arising due to poor maternal pregnancy diet in an offspring sex dependent fashion.

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confidence: 99%

Sugared water consumption by adult offspring of mothers fed a protein-restricted diet during pregnancy results in increased offspring adiposity: the second hit effect

et al. 2013

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“…In line with our results, protein malnutrition during lactation in rats resulted in lower anxiety in the offspring, measured by the elevated plus maze test at 10 weeks of age (Francolin-Silva, da Silva Hernandes, Fukuda, Valadares, & Almeida, 2006). However, no significant effects on anxiety was found in mouse offspring from dams with 30% maternal energy restriction during lactation, when tested in the elevated plus maze at the same age (Kumon, Yamamoto, Takahashi, Wada, & Wada, 2010). These results indicate that nutritional deficits early in life change anxiety-related behavior during adult life, and that the outcome can differ depending on whether there is a general undernutrition or malnutrition of certain nutrients such as protein or essential fatty acids.…”

Section: Discussionmentioning

confidence: 97%

Long-term effects of perinatal essential fatty acid deficiency on anxiety-related behavior in mice.

Pálsdóttir

Månsson²,

Blomqvist³

et al. 2012

Behavioral Neuroscience

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Dietary essential fatty acids have been shown to regulate behavioral and cognitive functions in rodents. However, the long-term effect on behavior, besides memory and learning, of essential fatty acid deficiency (EFAD), i.e., lack of n-3 and n-6 fatty acids, during the perinatal period has not been investigated. Therefore, pregnant C57Bl/6 mice were given either an EFAD or an isoenergetic control diet from gestational day 16 and throughout lactation. The female offspring were given standard chow from 3 weeks of age, and at 12 to 14 weeks of age, open-field, object recognition, light-dark transition, elevated plus maze, and social interaction tests were performed. The brain glycerophospholipid fatty acid composition was investigated in 3-week-old and adult offspring by gas chromatography. The differences observed in behavior were indicative of lower anxiety in the EFAD mice compared to controls illustrated by more time spent in the open arms of the elevated plus maze (+ 41%, p < .05) and in the light compartment in the light-dark transition test (+ 63%, p < .05). The proportion of total n-3 fatty acids, especially 22:6n-3 in the brain, was lower with a compensatory increase in the proportion of total n-6 fatty acids, foremost 22:5n-6, in the EFAD mice compared to controls at 3 weeks of age. In the adult brains the fatty acid composition was normalized. In conclusion, our data show that EFAD during the perinatal period results in short-term alterations of fatty acid composition in brain and decreased anxiety in adult life.

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“…8 The gestational protein restriction has permanent effects on the metabolism of the offspring, increasing the fetal oxidative stress mediated by ROS, 2 developing metabolic and cardiovascular diseases, 9 increasing the serum concentration of leptin in the adult male offspring 10 and triggering the onset of both insulin resistance and hepatic steatosis. [11][12][13][14] Likewise, a rich-carbohydrate diet has been associated with NAFLD in childhood and adulthood elevating the amount of hepatic TAG and lipogenesis, reducing the β-oxidation, and promoting liver inflammation. [15][16][17] Metabolic alterations provoked by gestational malnutrition can be aggravated by a post-weaning high-fat 18 or carbohydrate diet.…”

Section: Introductionmentioning

confidence: 99%

Hitting a triple in the non-alcoholic fatty liver disease field: sucrose intake in adulthood increases fat content in the female but not in the male rat offspring of dams fed a gestational low-protein diet

Nicolás-Toledo

Cervantes-Rodríguez

Cuevas-Romero

et al. 2017

J Dev Orig Health Dis

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The excessive consumption of carbohydrates is related to non-alcoholic fatty liver disease (NAFLD) in infants and adults. The effect of combining maternal malnutrition and a high carbohydrate intake on the development of NAFLD in adulthood remains unknown. We therefore hypothesized that consumption of 5% sucrose by the offspring of dams fed a low-protein diet during pregnancy promotes liver fat accumulation and oxidative damage differently in females and males. To test this, 12-month-old female and male offspring of mothers fed a Control (C) or low-protein diet (Restricted, R) were provided with either tap water or 5% sucrose for a period of 10 weeks. Livers were excised to measure the fat content and 3-nitrotyrosine (3-NTyr) immunostaining; serum samples were also obtained to measure the concentration of malondialdehyde (MDA). Data were analyzed using a non-repeated measures three-way analysis of variance to determine significant differences (P<0.05) regarding to the interaction among maternal diet, sucrose consumption and sex. Results showed that the liver fat content of females from R mothers was higher than that of their male counterpart. Hepatic 3-NTyr immunostaining and serum MDA concentrations were not affected by the interaction involving maternal diet, sucrose consumption and sex. Otherwise, liver fat content was correlated with the hepatic 3-NTyr immunostaining and serum MDA concentrations only in females. Thus, sucrose intake in adulthood increases fat content in the female but not in the male rat offspring of dams fed with a low-protein diet during pregnancy. This research emphasizes the importance of a balanced diet during pregnancy and the influence of the diet on the adult offspring.

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Maternal dietary restriction during lactation influences postnatal growth and behavior in the offspring of mice

Cited by 9 publications

References 38 publications

Sugared water consumption by adult offspring of mothers fed a protein-restricted diet during pregnancy results in increased offspring adiposity: the second hit effect

Sugared water consumption by adult offspring of mothers fed a protein-restricted diet during pregnancy results in increased offspring adiposity: the second hit effect

Long-term effects of perinatal essential fatty acid deficiency on anxiety-related behavior in mice.

Hitting a triple in the non-alcoholic fatty liver disease field: sucrose intake in adulthood increases fat content in the female but not in the male rat offspring of dams fed a gestational low-protein diet

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