Maternal early pregnancy obesity and related pregnancy and pre-pregnancy disorders: associations with child developmental milestones in the prospective PREDO Study

Girchenko, Polina; Tuovinen, Soile; Lahti‐Pulkkinen, Marius; Lahti, Jari; Savolainen, Katri; Heinonen, Kati; Pyhälä, Riikka; Reynolds, Rebecca M.; Hämäläinen, Esa; Villa, Piia M.; Kajantie, Eero; Pesonen, Anu‐Katriina; Laivuori, Hannele; Räikkönen, Katri

doi:10.1038/s41366-018-0061-x

Cited by 41 publications

(38 citation statements)

References 39 publications

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“…[44][45][46][47] Yet, in the PREDO maternal obesity or gestational diabetes were not associated with mother-rated internalizing, externalizing, or total psychiatric problems in 1.9-to 5.9-year-old children, 21 but were associated with child neurodevelopmental delay. 48 Prenatal depression also increases risks of preterm birth and low birth weight. 10,41 Also in the PREDO cohort, maternal depressive symptoms during pregnancy predicted shorter gestation length.…”

Section: Discussionmentioning

confidence: 99%

Fetal programming of neuropsychiatric disorders by maternal pregnancy depression: a systematic mini review

et al. 2018

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BACKGROUND: Maternal depression complicates a large proportion of pregnancies. Current evidence shows numerous harmful effects on the offspring. Reviews, which include depression, concluded that stress has harmful effects on the offspring's outcomes neuro-cognitive development, temperament traits, and mental disorders. OBJECTIVE: This mini review of recent studies, sought to narrow the scope of exposure and identify studies specifically assessing prenatal depression and offspring neuropsychiatric outcomes. STUDY ELIGIBILITY CRITERIA: The review included longitudinal, cohort, cross-sectional, clinical, quasi-experimental, epidemiological, or intervention study designs published in English from 2014 to 2018. PARTICIPANTS: Study populations included mother-child dyads, mother-father-child triads, mother-alternative caregiver-child triads, and family studies utilizing sibling comparisons. METHODS: We searched PubMED and Web of Science. Study inclusion and data extraction were based on standardized templates. The quality of evidence was assessed using the Newcastle-Ottawa Scale (NOS). RESULTS: Thirteen studies examining neuropsychiatric outcomes were included. We judged the evidence to be moderate to high quality. CONCLUSIONS: Our review supports that maternal prenatal depression is associated with neuropsychiatric adversities in children. IMPLICATIONS: Future investigations should unravel the biological underpinnings and target timely interventions as early in pregnancy as possible to prevent offspring neuropsychiatric harms.

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Section: Discussionmentioning

confidence: 99%

Fetal programming of neuropsychiatric disorders by maternal pregnancy depression: a systematic mini review

et al. 2018

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“…Maternal obesity during pregnancy is associated with increased adiposity and cardiometabolic risk factors in adult offspring [ 18 ]. Maternal obesity is also associated with impaired neurodevelopment and executive functioning [ 19 , 20 ] and with adverse neuropsychiatric outcomes in children [ 20 ], including Attention Deficit Hyperactivity Disorder (ADHD) [ 21 ] and Autism Spectrum Disorder (ASD) [ 22 , 23 ]. Studies in mouse models of maternal obesity suggest that there are adverse effects on brain development and behaviour [ 24 , 25 ] and in non-human primates, exposure to a high fat diet during pregnancy is associated with an increase in offspring anxiety-like and repetitive behaviours [ 26 ].…”

Section: Nutritionmentioning

confidence: 99%

Maternal influences on fetal brain development: The role of nutrition, infection and stress, and the potential for intergenerational consequences

Fitzgerald

Hor

Drake

2020

Early Human Development

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An optimal early life environment is crucial for ensuring ideal neurodevelopmental outcomes. Brain development consists of a finely tuned series of spatially and temporally constrained events, which may be affected by exposure to a sub-optimal intra-uterine environment. Evidence suggests brain development may be particularly vulnerable to factors such as maternal nutrition, infection and stress during pregnancy. In this review, we discuss how maternal factors such as these can affect brain development and outcome in offspring, and we also identify evidence which suggests that the outcome can, in many cases, be stratified by socio-economic status (SES), with individuals in lower brackets typically having a worse outcome. We consider the relevant epidemiological evidence and draw parallels to mechanisms suggested by preclinical work where appropriate. We also discuss possible transgenerational effects of these maternal factors and the potential mechanisms involved. We conclude that modifiable factors such as maternal nutrition, infection and stress are important contributors to atypical brain development and that SES also likely has a key role.

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“…Evidence suggests that maternal prepregnancy adiposity may be associated with reduced cognitive development and later cognition in children. 11,12,[17][18][19][20][21][22] Additionally, pregnancy weight gain may be independently linked to developmental outcomes. Recent data show that, from 6 to 16 years, children of women with excessive GWG may experience negative long-term outcomes, including reduced academic achievement and deficits in executive functiona composite indicator of general cognition, social acuity, and behavioral control.…”

Section: Introductionmentioning

confidence: 99%

Prepregnancy obesity is associated with lower psychomotor development scores in boys at age 3 in a low-income, minority birth cohort

Nichols

Rundle

Factor-Litvak

et al. 2019

J Dev Orig Health Dis

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Whether maternal obesity and gestational weight gain (GWG) are associated with early-childhood development in low-income, urban, minority populations, and whether effects differ by child sex remain unknown. This study examined the impact of prepregnancy BMI and GWG on early childhood neurodevelopment in the Columbia Center for Children’s Environmental Health Mothers and Newborns study. Maternal prepregnancy weight was obtained by self-report, and GWG was assessed from participant medical charts. At child age 3 years, the Psychomotor Development Index (PDI) and Mental Development Index (MDI) of the Bayley Scales of Infant Intelligence were completed. Sex-stratified linear regression models assessed associations between prepregnancy BMI and pregnancy weight gain z-scores with child PDI and MDI scores, adjusting for covariates. Of 382 women, 48.2% were normal weight before pregnancy, 24.1% overweight, 23.0% obese, and 4.7% underweight. At 3 years, mean scores on the PDI and MDI were higher among girls compared to boys (PDI: 102.3 vs. 97.2, P = 0.0002; MDI: 92.8 vs. 88.3, P = 0.0001). In covariate-adjusted models, maternal obesity was markedly associated with lower PDI scores in boys [b = −7.81, 95% CI: (−13.08, −2.55), P = 0.004], but not girls. Maternal BMI was not associated with MDI in girls or boys, and GWG was not associated with PDI or MDI among either sex (all-P > 0.05). We found that prepregnancy obesity was associated with lower PDI scores at 3 years in boys, but not girls. The mechanisms underlying this sex-specific association remain unclear, but due to elevated obesity exposure in urban populations, further investigation is warranted.

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Maternal early pregnancy obesity and related pregnancy and pre-pregnancy disorders: associations with child developmental milestones in the prospective PREDO Study

Abstract: Maternal early pregnancy overweight, obesity, and pre-eclampsia are independently associated with neurodevelopmental delay in her offspring. Further studies unraveling the underlying mechanisms are warranted.

Cited by 41 publications

References 39 publications

Fetal programming of neuropsychiatric disorders by maternal pregnancy depression: a systematic mini review

Fetal programming of neuropsychiatric disorders by maternal pregnancy depression: a systematic mini review

Maternal influences on fetal brain development: The role of nutrition, infection and stress, and the potential for intergenerational consequences

Prepregnancy obesity is associated with lower psychomotor development scores in boys at age 3 in a low-income, minority birth cohort

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