Maternal effect on micronucleus induction in MS/Ae mice

Abstract

MS/Ae mice, which are mutagen-sensitive in both the dominant lethal test and micronucleus test, and CD-1 mice, which are the parental strain of MS/Ae, were mated in all four possible combinations. Both male and female offspring were subjected to the micronucleus test using mitomycin C (MMC), colchicine (Col), and 6-mercaptopurine (6-MP). Col showed equivocal results. However, MMC and 6-MP showed differential responses in that both male and female offspring from CD-1 dams had lower incidences of micronucleated polychromatic erythrocytes than those from MS/Ae dams regardless of sire strain. In addition, body weights of offspring from MS/Ae dams were lower than those from CD-1 dams regardless of sire strain. Numbers of offspring from MS/Ae dams tended to be smaller than those from CD dams. These results suggest that the traits of MS/Ae mice are associated more with maternal factors than with paternal ones.

Bone marrow micronucleus assay: A review of the mouse stocks used and their published mean spontaneous micronucleus frequencies

“…To date, no study has thoroughly examined differences in the spontaneous frequencies among the many mouse stocks used with the assay. Several studies have attempted to compare the relative sensitivity of mouse stocks to clastogens [Aeschbacher et al, 1979;Aeschbacher 1986;Hayashi et al, 1982;Styles et al, 1983;Sat0 et al, 1987Sat0 et al, , 1990Sat0 et al, , 1993 The Collaborative Study Group (CSGMT), 19881. The problem with the approach used in these studies is that it is difficult to put together a study that incorporates enough different mouse stocks and participating test facilities, along with a sufficient number and variety of chemicals, to come to a definitive conclusion.…”

Entire nucleotide sequence of mitochondrial DNA of MS/Ae mice

“…Sutou and Sat0 [1990] hinted at involvement of a maternal factor@) in the inheritance of the high sensitivity to mutagens, but the mechanism was far from clear. The present study was conducted to learn if mitochondrial DNA is involved in the high sensitivity and, at the same time, to provide basic data for research into mitochondrial DNA.…”