Maternal Effects and the Endocrine Regulation of Mandrill Growth

Bernstein, Robin M.; Setchell, Joanna M.; Verrier, Delphine; Knapp, Leslie A.

doi:10.1002/ajp.22038

Cited by 15 publications

(12 citation statements)

References 41 publications

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“…The age-related changes associated with an increase of IGF-I levels during puberty in humans have also been found in non-human primates, such as macaques (45–47), baboons (48–50), mandrills (51), gibbons (52), and chimpanzees (53). As in humans, IGFBP-3 values of rhesus macaques and baboons reached their maxima during puberty [e.g., Ref.…”

Section: Introductionmentioning

confidence: 76%

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Sex Differences in Age-Related Decline of Urinary Insulin-Like Growth Factor-Binding Protein-3 Levels in Adult Bonobos and Chimpanzees

et al. 2016

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There is increasing interest in the characterization of normative senescence in humans. To assess to what extent aging patterns in humans are unique, comparative data from closely related species, such as non-human primates, can be very useful. Here, we use data from bonobos and chimpanzees, two closely related species that share a common ancestor with humans, to explore physiological markers that are indicative of aging processes. Many studies on aging in humans focus on the somatotropic axis, consisting of growth hormone (GH), insulin-like growth factors (IGFs), and IGF binding proteins (IGFBPs). In humans, IGFBP-3 levels decline steadily with increasing age. We used urinary IGFBP-3 levels as an alternative endocrine marker for IGF-I to identify the temporal pattern known to be related with age-related changes in cell proliferation, growth, and apoptosis. We measured urinary IGFBP-3 levels in samples from 71 bonobos and 102 chimpanzees. Focusing on samples from individuals aged 10 years or older, we found that urinary IGFBP-3 levels decline in both ape species with increasing age. However, in both species, females start with higher urinary IGFBP-3 levels than males, experience a steeper decline with increasing age, and converge with male levels around the age of 30–35 years. Our measurements of urinary IGFBP-3 levels indicate that bonobos and chimpanzees mirror human patterns of age-related decline in IGFBP-3 in older individuals (<10 years) of both sexes. Moreover, such as humans, both ape species show sex-specific differences in IGFBP-3 levels with females having higher levels than males, a result that correlates with sex differences in life expectancy. Using changes in urinary IGFBP-3 levels as a proxy for changes in GH and IGF-I levels that mark age-related changes in cell proliferation, this approach provides an opportunity to investigate trade-offs in life-history strategies in cross-sectional and in longitudinal studies, both in captivity and in the wild.

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Section: Introductionmentioning

confidence: 76%

“…IGF-I levels are higher in young female chimpanzees than in males (53), whereas in baboons and mandrills the opposite was shown (49, 51). …”

Section: Introductionmentioning

confidence: 95%

Sex Differences in Age-Related Decline of Urinary Insulin-Like Growth Factor-Binding Protein-3 Levels in Adult Bonobos and Chimpanzees

et al. 2016

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“…This suggests that social rank acts independently of IGF‐1 in mediating size; which has also been found in juvenile mandrills (Bernstein et al . ). Lastly, there appeared to be no effect of prey density on IGF‐1 concentrations ( t 65 = −0·30, P = 0·77; Table S2).…”

Section: Discussionmentioning

confidence: 97%

Juvenile concentrations of IGF‐1 predict life‐history trade‐offs in a wild mammal

et al. 2016

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Summary Early postnatal development can have profound effects on life‐history traits later in life. One mechanism hypothesized to mediate this relationship is the anabolic hormone, insulin‐like growth factor‐1 (IGF‐1). IGF‐1 contributes importantly to postnatal growth, and thus offers a means by which environmental and genetic variation might direct organismal development, reproduction and survival. We tested whether juvenile concentrations of IGF‐1 can predict intraspecific variation in life‐history traits later in life using longitudinal data from free‐living female spotted hyenas (Crocuta crocuta). We found that juvenile concentrations of IGF‐1 predicted heavier juvenile mass, which in turn predicted greater survival to reproductive maturity. However, independent of mass, higher juvenile concentrations of IGF‐1 predicted earlier age at first parturition and reduced longevity in adulthood. Our results highlight the importance of early postnatal development as a determination period in mammals and suggest that concentrations of IGF‐1 during this sensitive period can be used to predict important later‐life trade‐offs between growth, reproductive fitness and life span in wild, long‐lived animals. A http://onlinelibrary.wiley.com/doi/10.1111/1365-2435.12808/suppinfo is available for this article.

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“…The endocrine system is comprised of multiple endocrine tissues that produce and secrete hormones directly to the circulation to regulate somatic function. The endocrine system, in co‐operation with the nervous and immune systems,1 regulates different physiological processes, such as maintenance of homeostasis,2 regulation of energy balance,3, 4 development, growth5, 6 and reproduction 7, 8…”

Section: Introductionmentioning

confidence: 99%

Nanotoxicity: A Growing Need for Study in the Endocrine System

Liu

Kong

et al. 2013

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Nanomaterials (NMs) are engineered for commercial purposes such as semiconductors, building materials, cosmetics, and drug carriers, while natural nanoparticles (NPs) already exist in the environment. Due to their unique physicochemical properties, they may interact actively with biological systems. Some of these interactions might be detrimental to human health, and therefore studies on the potential 'nanotoxicity' of these materials in different organ systems are warranted. The purpose of developing the concept of nanotoxicity is to recognize and evaluate the hazards and risks of NMs and evaluate safety. This review will summarize and discuss recent reports derived from cell lines or animal models concerning the effects of NMs on, and their application in, the endocrine system of mammalian and other species. It will present an update on current studies of the effects of some typical NMs-such as metal-based NMs, carbon-based NMs, and dendrimers-on endocrine functions, in which some effects are adverse or unwanted and others are favorable or intended. Disruption of endocrine function is associated with adverse health outcomes including reproductive failure, metabolic syndrome, and some types of cancer. Further investigations are therefore required to obtain a thorough understanding of any potential risk of pathological endocrine disruption from products containing NMs. This review aims to provide impetus for further studies on the interactions of NMs with endocrine functions.

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Maternal Effects and the Endocrine Regulation of Mandrill Growth

Cited by 15 publications

References 41 publications

Sex Differences in Age-Related Decline of Urinary Insulin-Like Growth Factor-Binding Protein-3 Levels in Adult Bonobos and Chimpanzees

Sex Differences in Age-Related Decline of Urinary Insulin-Like Growth Factor-Binding Protein-3 Levels in Adult Bonobos and Chimpanzees

Juvenile concentrations of IGF‐1 predict life‐history trade‐offs in a wild mammal

Nanotoxicity: A Growing Need for Study in the Endocrine System

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