Maternal Endocrine Activation During Pregnancy Alters Neurobehavioral State in Primate Infants

Roughton, Elizabeth C.; Schneider, Mary L.; Bromley, Lyn J.; Coe, Christopher L.

doi:10.5014/ajot.52.2.90

Cited by 23 publications

(16 citation statements)

References 24 publications

(29 reference statements)

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“…This conclusion concurs with research showing that population variation in mother-infant interactions depends upon several characteristics, including maternal-typical behavior (Weaver, Richardson, Worlein, De Waal, & Laudenslager, 2004), infant temperament (Coe et al, 2010; Mantymaa et al, 2006; Roughton, Schneider, Bromley, & Coe, 1998) and environmental context (Ellis et al, 2012). Studies in rodents have revealed how variation in maternal care can have far-reaching consequences on emotional reactivity and brain development, which may continue to be manifest even in subsequent generations (Champagne & Meaney, 2007).…”

Section: Discussionsupporting

confidence: 90%

Stability of parental care across siblings from undisturbed and challenged pregnancies: Intrinsic maternal dispositions of female rhesus monkeys.

Shirtcliff¹,

Phan²,

Lubach³

et al. 2013

Developmental Psychology

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The concept of fetal programming is based on the idea that the developmental trajectory of infants is adjusted in response to in utero conditions. In species with extended parental care, these prenatally-derived tendencies are further substantiated by behavioral attributes of the mother during the postnatal period. We investigated the stability of maternal behavioral interactions with infant monkeys, and carefully varied prenatal conditions across siblings reared by the same mother. We hypothesized that effects of prenatal disturbance and the infant’s susceptibility would be differentially affected by maternal attributes. Hierarchical Linear Modeling was employed to analyze observational data on 121 rhesus macaques reared by a total of 35 multiparous mothers. A portion of the variance in 5 dyadic behaviors was statistically driven by the infant (or was unique to a particular mother-infant pair), but stable maternal propensities and a consistent style of care across siblings also substantially influenced behavioral interactions. Moreover, the magnitude and direction of the prenatal effects were contingent on a female’s intrinsic dispositions. When mothers typically exhibited high levels of a corresponding behavior, responsiveness to infants was enhanced as a consequence of prenatal disturbance. The opposite was true for less expressive females. Challenges to the wellbeing of pregnancy thus served to accentuate maternal predispositions and served to magnify the range of variation in mother-infant behavior across the whole population.

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Section: Discussionsupporting

confidence: 90%

Stability of parental care across siblings from undisturbed and challenged pregnancies: Intrinsic maternal dispositions of female rhesus monkeys.

Shirtcliff¹,

Phan²,

Lubach³

et al. 2013

Developmental Psychology

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“…Prenatal stress affects cognitive abilities including operant discrimination [91] , reversal task in a water maze [92,93] and memory [94] . In other animal studies, maternal stress during pregnancy results in offspring that are more irritable, anxious and difficult to control [61,[95][96][97][98] .…”

Section: The Third Pathophysiology Of Cocaine: Fetal Programmingmentioning

confidence: 99%

Third Pathophysiology of Prenatal Cocaine Exposure

Lester

Padbury²

2009

Dev Neurosci

130

148

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The pathophysiology of the effects of cocaine on fetal development has been described along 2 major pathways: neurochemical effects and vasoconstrictive effects. Following a summary of these effects, we suggest a ‘third pathophysiology’ in which altered fetal programming affects the acute and long-term adverse effects of in utero cocaine exposure. We describe how cocaine as a stressor alters the expression of key candidate genes, increasing exposure to catecholamines and fetal cortisol-altering neuroendocrine (hypothalamic-pituitary-adrenal axis) activity, leading to infant behavioral dysregulation, poor behavioral control and emotion regulation during childhood and phenotypes that confer vulnerability to substance use in adolescence. This model is discussed in relation to follow-up studies of the effects of in utero cocaine exposure and maturational changes in brain development.

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“…That may be changing, however, as human research begins to translate the experimental animal findings showing that prenatal stress is a central paradigm for demonstrating long-term effects of prenatal exposures on behavioral and biological development (Coe et al, 2003; Maccari et al, 2003; Weinstock, 2005). Abundant animal work using the prenatal stress paradigm points to glucocorticoid exposure as a leading candidate mechanism (Maccari et al, 2003; Matthews, 2000; Roughton et al, 1998; Seckl & Holmes, 2007; Weinstock, 2005). The specific mechanisms of action underlying the programming effect are unconfirmed, but may include increased activation of the offspring HPA axis, alteration of glucocorticoid receptor sensitivity, and alteration of genetic expression in the stress response system.…”

mentioning

confidence: 99%

In utero cortisol and testosterone exposure and fear reactivity in infancy

Bergman

Glover

Sarkar

et al. 2010

Hormones and Behavior

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Fetal programming is emerging as a major conceptual model for understanding developmental origins of health and disease, including behavioral outcomes. As part of a larger study of prenatal stress and child development, we examined the association between prenatal hormone exposure and fear reactivity, a temperament dimension that is a predictor of long-term behavioral adjustment. Amniotic fluid was collected from a sample of women undergoing clinically indicated amniocentesis for later analysis of cortisol and testosterone. Children with normal birth outcomes were recalled for follow-up assessment at 17 months, at which time we administered an observational assessment of temperament (lab-TAB; n=108). Information on pregnancy and obstetric outcome was included as covariates. Results indicated that there was a significant association between prenatal testosterone and observed fear reactivity in boys (r(53)=0.34, p=0.01); no significant effect was found in girls (r(54)=-.07, ns); the effect remained when obstetric, psychosocial, and parental anxiety were controlled for. There was not a significant association between fetal cortisol exposure and fear reactivity. The prediction from in utero testosterone exposure to fear reactivity in boys extends prior research on prenatal testosterone, and may represent an association with a general predisposition to greater arousal and reactivity.

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Maternal Endocrine Activation During Pregnancy Alters Neurobehavioral State in Primate Infants

Cited by 23 publications

References 24 publications

Stability of parental care across siblings from undisturbed and challenged pregnancies: Intrinsic maternal dispositions of female rhesus monkeys.

Stability of parental care across siblings from undisturbed and challenged pregnancies: Intrinsic maternal dispositions of female rhesus monkeys.

Third Pathophysiology of Prenatal Cocaine Exposure

In utero cortisol and testosterone exposure and fear reactivity in infancy

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