Maternal environmental risk factors for congenital hydrocephalus: a systematic review

Kalyvas, Aristotelis; Κalamatianos, Theodosis; Pantazi, Mantha; Lianos, Georgios D; Stranjalis, George; Alexiou, George Α.

doi:10.3171/2016.8.focus16280

Cited by 28 publications

(22 citation statements)

References 29 publications

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“…Several covariates were evaluated as potential confounders or effect modifiers based on previously described associations with the birth defects of interest or PAHs in the literature (Anderson et al, 2005;Bhatti et al, 2003;Canfield, Langlois, Nguyen, & Scheuerle, 2009;Croen et al, 2000;Forrester & Merz, 2006;Hackshaw et al, 2011;Johnson & Rasmussen, 2010;Kalyvas et al, 2016;Kancherla et al, 2014;Mastroiacovo et al, 1995;Miller et al, 2010;Prakalapakorn, Rasmussen, Lambert, & Honein, 2010;Reeder et al, 2015;Shaw, Carmichael, Kaidarova, & Harris, 2003Stothard, Tennant, Bell, & Rankin, 2009;Zhang, Zhang, Yu, & Shen, 2009): maternal age at delivery; maternal race/ethnicity; maternal prepregnancy body mass index (BMI); maternal diabetes; maternal smoking; maternal alcohol consumption; maternal exposure to second-hand smoke at home or work; infant sex; gestational age of infant at birth; and infant birthweight. Study center was also considered.…”

Section: Covariatesmentioning

confidence: 99%

Association between maternal occupational exposure to polycyclic aromatic hydrocarbons and rare birth defects of the face and central nervous system

Santiago-Colón

Rocheleau

Chen

et al. 2020

Birth Defects Research

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Background Previous studies suggested associations between maternal smoking, a source of exposure to polycyclic aromatic hydrocarbons (PAHs) and other chemicals, and central nervous system and face birth defects; however, no previous studies have evaluated maternal occupational PAH exposure itself. Methods Jobs held in the periconceptional period were retrospectively assigned for occupational PAH exposures. Associations between maternal occupational PAH exposure and selected rare defects of the face (cataracts, microphthalmia, glaucoma, microtia, and choanal atresia) and central nervous system (holoprosencephaly, hydrocephaly, cerebellar hypoplasia, and Dandy‐Walker malformation) were evaluated using data from the National Birth Defects Prevention Study, a population‐based case–control study in the United States. Crude and adjusted odds ratios (ORs) with 95% confidence intervals were calculated to estimate associations between each evaluated defect and PAH exposure using multivariable logistic regression. Results Food and beverage serving, as well as cooks and food preparation occupations, were among the most frequent jobs held by exposed mothers. Cataracts, microtia, microphthalmia, and holoprosencephaly were significantly associated with PAH exposure with evidence of dose–response (P‐values for trend ≤.05). Hydrocephaly was associated with any PAH exposure, but not significant for trend. Sensitivity analyses that reduced possible sources of exposure misclassification tended to strengthen associations. Conclusions This is the first population‐based case–control study to evaluate associations between maternal occupational PAH exposures and these rare birth defects of the central nervous system and face.

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Section: Covariatesmentioning

confidence: 99%

Association between maternal occupational exposure to polycyclic aromatic hydrocarbons and rare birth defects of the face and central nervous system

Santiago-Colón

Rocheleau

Chen

et al. 2020

Birth Defects Research

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“…The systematic review showed that complete lack of prenatal care is strongly associated with CH specifically and initiating prenatal care after the 8 th month of gestation is also related to the development of CH. 9 The present study highlights the lack of prenatal care in women bearing babies with congenital hydrocephalus. It is apparent from our study that most (94.30%) of these women presented in third trimester when the foetal condition was diagnosed.…”

Section: Discussionmentioning

confidence: 69%

“…1 Hence, findings should be interpreted cautiously and regarded as possible future avenues of research under epidemiological, clinical, and preclinical settings. 9,14,15,16 CONCLUSION First or second pregnancies of young, illiterate women from rural background are more prone to congenital hydrocephalus. Even though a genetic basis has been speculated, most of the causative factors still remain unclear for this disorder which has wide ranging health and financial implications for the affected individuals and their families.…”

Section: Discussionmentioning

confidence: 99%

Congenital Hydrocephalus- An Epidemiological Study of Maternal Characteristics in a Tertiary Care Centre

Kadian¹,

Verma²,

Kajal³

et al. 2017

jemds

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BACKGROUNDThe epidemiology of congenital hydrocephalus is very unclear. Although various risk factors like maternal age, maternal illness and child factors have been studied in the past, still there is a gap of knowledge regarding maternal risk factors associated in congenital hydrocephalus in the literature.The objective of the study is to measure risk factor proportions of mothers among the population of a tertiary care centre. MATERIALS AND METHODSA record-based, retrospective, descriptive study with secondary data analysis was done from the medical case records of women who delivered babies with congenital hydrocephalus from Jan. 2006 to Dec. 2016. Maternal epidemiological characteristics such as maternal age, parity, place of residence, educational status as well as birth characteristics were studied and analysed by using appropriate statistical methods. RESULTSA total of 123 babies were born with congenital hydrocephalus during the study period. Most mothers in the study were second gravida (56.91%), rural based (74.79%), women between 21-30 years (80.48%) of age. Around 60.16% women were educated up to 10 th grade and most (41.46%) were homemakers. All but 5 women had vaginal births. Male babies were 52.03%, and 64.78% babies weighed above 2 kg at birth. CONCLUSIONYoung women from rural areas of low literacy and bearing their second babies are more prone to deliver babies with congenital hydrocephalus.

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“…Maternal infections and trauma to the mother during pregnancy have also been highlighted as potential mother-related risk factors. 9 Despite the significant investment in improving maternal healthcare, disparities exist between socio-economic strata and this has an influence on the incidence of hydrocephalus, which explains the high number of cases within the public health sector.…”

Section: Discussionmentioning

confidence: 99%

"A tale of two cities." A snapshot survey of neurosurgical procedures performed in public and private sectors in eThekwini

et al. 2019

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Access to neurosurgical care in South Africa is influenced by prevailing inequities in healthcare. It is generally perceived that the public sector performs mainly emergencies relating to trauma, and the private sector performs mainly elective spinal surgery. In March 2015, emergencies constituted 51% of cases in the public sector compared to 8% in the private sector. Trauma, paediatric hydrocephalus and intracranial sepsis constituted nearly 75% of the operative workload in the public sector. Cranial surgery accounted for the majority (95%) of operations in the public sector, whereas the majority in the private sector was spinal (75%). There is considerable disparity in the type of neurosurgery being performed in the public and private sectors in KwaZulu-Natal and with the current financial constraints, there is a potential unmet need for elective spinal surgery in the public sector.

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Maternal environmental risk factors for congenital hydrocephalus: a systematic review

Cited by 28 publications

References 29 publications

Association between maternal occupational exposure to polycyclic aromatic hydrocarbons and rare birth defects of the face and central nervous system

Association between maternal occupational exposure to polycyclic aromatic hydrocarbons and rare birth defects of the face and central nervous system

Congenital Hydrocephalus- An Epidemiological Study of Maternal Characteristics in a Tertiary Care Centre

"A tale of two cities." A snapshot survey of neurosurgical procedures performed in public and private sectors in eThekwini

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