Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice

Chen, Guangquan; Xiong, Shiyi; Qiao, Jie; Gestel, C.A.M. van; Straalen, Nico M. van; Roelofs, Dick; Sun, Luming; Qiu, Hao

doi:10.1016/j.scitotenv.2022.158666

Cited by 48 publications

(23 citation statements)

References 57 publications

(76 reference statements)

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“…The widespread distribution of MPs across all placenta samples underscores the significance of investigating their potential consequences on placental function and fetal development, an area of investigation that has been relatively unexplored, particularly in human populations. Evidence collected using rodent models of gestational MP exposure have demonstrated smaller placentas (Fournier et al, 2020;Hu et al, 2021;Nie et al, 2021), impaired feto-placental and uteroplacental vasculature development (Chen et al, 2022;Hu et al, 2021), disturbances in uterine immune cell balance (Hu et al, 2021) and placental metabolic disruption (Aghaei et al, 2022;Chen et al, 2022) . In vitro exposure of human placental tissue to MPs has also been shown to alter expression of genes and proteins related to inflammation and iron homeostasis (Chortarea et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

Particulate Contamination of Human Placenta: Plastic and non-plastic

Zurub,

Bainbridge,

Rahman

et al. 2024

Preprint

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Recent evidence indicates that the human womb is contaminated with a variety of particulate contaminants. Microplastics (MPs, tiny plastic particles (<5 mm) generated by the breakdown of larger plastic products in the environment) accumulation in human placenta has recently been described. In addition, recent evidence has correlated the number of air pollution particulates in term placentas to the loading of these particles in dust from the gestational parent home. The current study sought to characterize the accumulation of plastic and non-plastic particles (NPP) within the term human placenta. Placenta tissues were collected from healthy, singleton pregnancies following vaginal (n=5) and caesarean section (n=5) deliveries at a tertiary care centre located in an urban Canadian city (Ottawa, ON), with particles detected and characterized by Raman micro-spectroscopy. Both plastic and non-plastic particles were identified in all placentas examined, with an average of 1 ± 1.2 MPs /g and 4 ± 2.9 NPP /g of tissue. Similar tissue concentrations of MPs and NNP were identified in all regions of the placenta (basal plate, chorionic villous, chorionic plate), and did not differ according to mode of delivery. MPs ranged in size (2 - 60 μm), with the most abundant MPs being polyethylene (PE), polypropylene (PP), polystyrene (PS) and polyvinyl chloride (PVC). The most abundantly identified NPP were carbon, graphite, and lead oxide. Collectively, these results demonstrate the accumulation of foreign particles, including MPs, throughout the human placenta. Given the vital functions of the placenta in supporting fetal growth and development, and a potential for MPs to induce toxicity, further investigations into the potential harmful effects of these environmental toxicants on maternal and fetal health is warranted.

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Section: Discussionmentioning

confidence: 99%

Particulate Contamination of Human Placenta: Plastic and non-plastic

Zurub,

Bainbridge,

Rahman

et al. 2024

Preprint

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“…Moreover, AEE increased the expression of APOA4 in the liver. APOA4 can promote cholesterol metabolism, and the overexpression of APOA4 can lead to the inhibition of lipogenesis, increased fat decomposition, and the oxidation of fatty acids [ 72 , 73 ]. In summary, AEE can effectively relieve the enhancement of phenylalanine catabolism, the decrease in tyrosine catabolism, and the disordered lipid and cholesterol metabolism in immune-stressed broilers.…”

Section: Discussionmentioning

confidence: 99%

Effects of Aspirin Eugenol Ester on Liver Oxidative Damage and Energy Metabolism in Immune-Stressed Broilers

Zhong,

Zhen,

Bai

et al. 2024

Antioxidants

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The aim of this study was to investigate the effects of aspirin eugenol ester (AEE) on liver oxidative damage and energy metabolism in immune-stressed broilers. In total, 312 broilers were divided into 4 groups (saline, LPS, SAEE, and LAEE). Broilers in the saline and LPS groups were fed a basal diet; the SAEE and LAEE groups had an added 0.01% AEE in their diet. Broilers in the LPS and LAEE groups were injected with lipopolysaccharides, while the saline and SAEE groups were injected with saline. Results showed that AEE increased the body weight, average daily gain, and average daily feed intake, as well as decreasing the feed conversion ratio of immune-stressed broilers. AEE protects against oxidative damage in immune-stressed broiler livers by elevating the total antioxidant capacity, superoxide dismutase activity, and glutathione S-transferase alpha 3 (GSTA3) and glutaredoxin 2 (GLRX2) expression, while decreasing malondialdehyde content. AEE lessened inflammation by reducing prostaglandin-F2α production and prostaglandin-endoperoxide synthase 2 (PTGS2) and interleukin-1beta (IL-1β) expression. AEE decreased oxidative phosphorylation rates by increasing succinic acid levels and lowering both adenosine diphosphate (ADP) levels and ceroid lipofuscinosis neuronal 5 (CLN5) expression. AEE modulated the metabolism of phenylalanine, tyrosine, lipids, and cholesterol by reducing the phenyllactate and L-arogenate levels, lowering dopachrome tautomerase (DCT) and apolipoprotein A4 (APOA4) expression, and increasing phenylpyruvic acid and dopa decarboxylase (DDC) expression. In summary, AEE can effectively alleviate liver oxidative damage and energy metabolism disorders in immune-stressed broilers.

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“…Mounting evidence suggest that MNPs accumulate within and affect the proper functioning of the placenta – the vital organ of pregnancy responsible for all maternal-fetal exchange ( 95 ).The presence of MNP accumulation in placental tissue of rats treated with PS-MNPs was first described in 2020 ( 96 ) and has since been reproduced in many studies in mice ( 97 – 99 ), with observed structural and functional consequences ( 96 – 101 ). Exposed females (MNPs between 100 nm-10 μm) have smaller placentas ( 96 , 98 ), reduced numbers of glycogen-containing cells within the placental endocrine-functioning junctional zone ( 100 ), and poorly developed feto-placental vasculature ( 100 ). The remodelling of the uterine spiral arteries is also compromised, likely the result of uterine and placental immune cell imbalances (i.e., decreased uterine natural killer cells, altered macrophage ratio) ( 97 ).…”

Section: Mnp Exposure In Pregnancymentioning

confidence: 99%

“…The remodelling of the uterine spiral arteries is also compromised, likely the result of uterine and placental immune cell imbalances (i.e., decreased uterine natural killer cells, altered macrophage ratio) ( 97 ). In addition, transcriptomic and metabolic analyses of MNP-exposed placentas demonstrate disturbed amino acid, glucose and cholesterol metabolism and complement/coagulation cascades pathways ( 100 , 101 ).…”

Section: Mnp Exposure In Pregnancymentioning

confidence: 99%

Microplastics exposure: implications for human fertility, pregnancy and child health

Zurub,

Cariaco,

Wade

et al. 2024

Front. Endocrinol.

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Plastics found in our everyday environment are becoming an increasing concern for individual and population-level health, and the extent of exposure and potential toxic effects of these contaminants on numerous human organ systems are becoming clear. Microplastics (MPs), tiny plastic particles, appear to have many of the same biological effects as their plastic precursors and have the compounded effect of potential accumulation in different organs. Recently, microplastic accumulation was observed in the human placenta, raising important questions related to the biological effects of these contaminants on the health of pregnancies and offspring. These concerns are particularly heightened considering the developmental origins of health and disease (DOHaD) framework, which postulates that in utero exposure can programme the lifelong health of the offspring. The current review examines the state of knowledge on this topic and highlights important avenues for future investigation.

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Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice

Cited by 48 publications

References 57 publications

Particulate Contamination of Human Placenta: Plastic and non-plastic

Particulate Contamination of Human Placenta: Plastic and non-plastic

Effects of Aspirin Eugenol Ester on Liver Oxidative Damage and Energy Metabolism in Immune-Stressed Broilers

Microplastics exposure: implications for human fertility, pregnancy and child health

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