Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the neuropsychomotor development of 90 days old babies: "Pregnancy care, healthy baby" study

Maternal hsa-miR-423-5p associated with the cognitive development of babies in pregnant women without mental disorders

“…The contribution of this study is the identification of miR-423-5p expression levels in maternal blood and its ability to influence the cognitive development of infants at 90 days of age, which suggests a probable biomarker to be used in future. In addition, we call attention to the study previously published by our research group ( Nedel et al, 2023 ), which showed that the expression of specific microRNAs in the maternal blood during pregnancy would be associated with the cognitive development of babies; however, it was also evident that the presence of mood disorders during pregnancy was also associated with child development deficit in this period. A question of reverse causality and another question of possible mediation of the child development outcome was posed.…”

“…However, we had the exclusion criteria as a difference, which were mood disorders anxiety disorders, or suicidal ideation until the moment of evaluation and collection of biological material. Therefore, 60 days after the initial assessment, all women were re-evaluated in relation to the presence of mental health disorders, thus ensuring that these pregnant women did not present the aforementioned disorders during this period, which differentiates our sample from the study carried out by Nedel et al (2023) , which did not exclude the manifestation of mental health disorders at any time during the evaluation periods.…”

“…For more details about sample capture, read the publications of Pinheiro et al (2021Pinheiro et al ( , 2022. The study design is similar to the one carried out by Nedel et al (2023), in which dyads (mother-baby) were included. However, we had the exclusion criteria as a difference, which were mood disorders anxiety disorders, or suicidal ideation until the moment of evaluation and collection of biological material.…”