Maternal feeding associated to post-weaning diet affects metabolic and behavioral parameters in female offspring

Fisch, Joana; Feistauer, Vanessa; Moura, Ana Carolina de; Silva, Andrew Oliveira; Bollis, Vanessa; Porawski, Marilene; Almeida, Silvana; Guedes, Renata Padilha; Barschak, Alethéa Gatto; Giovenardi, Márcia

doi:10.1016/j.physbeh.2019.02.026

Cited by 15 publications

(6 citation statements)

References 42 publications

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“…Differently, no anxiety‐like behaviors were observed in the present study, as showed by the behaviors in EPM. This was supported by Fisch’ s data 31 . Of note, the maternal diet could modify the offspring’s fear reactivity to a predator odor in their adulthood despite the normal behaviors in the OF and EPM 32 .…”

Section: Discussionsupporting

confidence: 55%

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Maternal high‐salt diet during pregnancy impairs synaptic plasticity and memory in offspring

et al. 2021

The FASEB Journal

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Sodium chloride is a major source of salt in human nutrition. It is well-known that long-term high-salt diet (HSD) was associated with the development of hypertension and cardiovascular disease, especially when sodium intake exceeds 5 g/day. 1 There is an emerging evidence that the consumptions of dietary sodium are usually excess of requirements in the form of salt in many countries among adults and childrens, and then, leading to the excess weight gain. 2 Strikingly, both experimental data from animal and epidemiological data from clinical investigations in human being demonstrated that long-term HSD may cause cognitive dysfunction and brain tissue damage in adult individuals. 3,4 Data from rodents reported that HSD impaired cognitive function without changing blood pressure. 5,6 Furthermore, HSD disturbed the short-and long-term memory of mouse with corresponding increases in hippocampal oxidative stress and deregulation of synaptic protein/neurotrophin. 6 The importance of adequate maternal nutrition during the development for offspring's long-term physical health has

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Section: Discussionsupporting

confidence: 55%

“…This was supported by Fisch' s data. 31 Of note, the maternal diet could modify the offspring's fear reactivity to a predator odor in their adulthood despite the normal behaviors in the OF and EPM. 32 Thus, further investigations that regard to the effects of maternal HSD on other emotions in the offspring are needed.…”

Section: Discussionmentioning

confidence: 99%

Maternal high‐salt diet during pregnancy impairs synaptic plasticity and memory in offspring

et al. 2021

The FASEB Journal

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“…These data indicate maternal nutritional stress alters neurobehavioral and immune responses in rodent offspring, but not all necessarily in a consistent manner between and even within the same models ( Sasaki et al, 2014 ). Many prenatal caloric restriction (CR) studies in rodents show increased anxiety-like behavior in male and female adult offspring ( Levay et al, 2008 ; Sheng et al, 2021 ), while others show decreased anxiogenic behavior in adult offspring ( Govic et al, 2016 ; Fisch et al, 2019 ) or no changes in anxiety-like behavior with improved, memory performance, novelty-seeking and locomotor activity in adult male offspring ( Lotufo et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluating different models of maternal stress on stress-responsive systems in prepubertal mice

Sheng,

Handa,

Tobet

2023

Front. Neurosci.

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IntroductionMaternal adversity during pregnancy influences neurodevelopment in human and model animal offspring. Adversity can result from stressors coming from many different directions ranging from environmental to nutritional and physiological to immune (e.g., infection). Most stressors result in fetal overexposure to glucocorticoids that have been directly linked to long- and short-term negative impacts on neurological health of offspring. Neuropsychiatric diseases postulated to have fetal origins are diverse and include such things cardiovascular disease, obesity, affective disorders, and metabolic and immune disorders.MethodsThe experiments in the current study compare 3 stressors: prenatal exposure to dexamethasone (DEX), maternal high fat diet (HFD), and maternal caloric restriction (CR). Offspring of mothers with these treatments were examined prepubertally to evaluate stress responsiveness and stress-related behaviors in in male and female mice.ResultsPrenatal exposure to synthetic glucocorticoid, DEX, resulted in decreased neonatal body weights, reduced social interaction behavior, and hypoactive stress response offspring exposed to maternal DEX. Maternal CR resulted in decreased body weights and social interaction behavior in males and females and increased anxiety-like behavior and acute stress response only in males. HFD resulted in altered body weight gain in both sex offspring with decreased anxiety-like behavior in a female-biased manner.DiscussionThe idea that glucocorticoid responses to different stressors might serve as a common stimulus across stress paradigms is insufficient, given that different modes of prenatal stress produced differential effects. Opposite nutritional stressors produced similar outcomes for anxiety-like behavior in both sexes, social-like behavior in females, and a hyperactive adrenal stress response in males. One common theme among the three models of maternal stress (DEX, CR, and HFD) was consistent data showing their role in activating the maternal and fetal immune response. By tuning in on the more immediate immunological aspect on the developing fetus (e.g., hormones, cytokines), additional studies may tease out more direct outcomes of maternal stress in rodents and increase their translational value to human studies.

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“…Maternal effects include the environment experienced by the mother and nutrients belonging to the early life period that considerably influences offspring phenotype and growth [5,6]. Unbalanced maternal nutrition would lead to a mismatch in the maternal-offspring environment, suboptimal offspring growth [7], and health problems associated with metabolic dysfunction [8]. In pigs and mammals, the maternal effects continue during the lactation period and only stop when the piglets are weaned.…”

Section: Introductionmentioning

confidence: 99%

Proteomic changes associated with maternal dietary low ω6:ω3 ratio in piglets supplemented with seaweed Part II: Ileum proteomes

Nguyen

Agazzi

McGill

et al. 2023

Journal of Proteomics

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Maternal feeding associated to post-weaning diet affects metabolic and behavioral parameters in female offspring

Cited by 15 publications

References 42 publications

Maternal high‐salt diet during pregnancy impairs synaptic plasticity and memory in offspring

Maternal high‐salt diet during pregnancy impairs synaptic plasticity and memory in offspring

Evaluating different models of maternal stress on stress-responsive systems in prepubertal mice

Proteomic changes associated with maternal dietary low ω6:ω3 ratio in piglets supplemented with seaweed Part II: Ileum proteomes

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