Maternal, fetal and neonatal consequences associated with the use of crack cocaine during the gestational period: a systematic review and meta-analysis

Santos, João Filipe; Cavalcante, Cibelle de Melo Bastos; Barbosa, Fabiano Timbó; Gitaí, Daniel Leite Góes; Duzzioni, Marcelo; Tilelli, Cristiane Queixa; Shetty, Ashok K.; Castro, Olagide Wagner de

doi:10.1007/s00404-018-4833-2

Cited by 52 publications

(34 citation statements)

References 120 publications

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“…The age and low income of these mothers may have influenced the use of drugs, tobacco, or alcohol during pregnancy. In addition, several studies support that drug, cigarette, or alcohol use during pregnancy are risk factors for preterm delivery [18][19][20]. The use of these drugs is associated with spontaneous preterm delivery, premature rupture of membranes, and prepartum bleeding [18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Difference of Socioeconomic Factors among Mothers of Preterm and Full-Term Infant

Carcavalli

Rocha

Valentim

et al. 2020

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To analyze the difference of socioeconomic factors among mothers of preterm and full-term infants. Material and Methods: A cross-sectional retrospective study was developed with 250 mothers of children aged three to five years. The sample was divided into two groups: 125 mothers of preterm infants from the referral center of a public hospital in the city of Belo Horizonte, Brazil and 125 mothers of children born full-term at a daycare center within the same city. A pre-tested questionnaire was used to collect socioeconomic data and type of breastfeeding. To verify if there was association between the dependent variable gestational age at birth and the independent variables, the chi-square test was used. A final model with multiple Poisson regression estimated prevalence ratio values for each independent variable was developed. Results: The final multiple regression model showed that mothers that have a low monthly income of up to USD 450.28 (PR = 1.979, 95% CI = 1.082-3.620), used drugs, cigarettes, or alcohol during their pregnancy (PR = 4.095, 95% CI = 2.422-6.921), and did not breastfeed (PR = 2.294, 95% CI = 1.205-4.369) were more likely to give birth to preterm infants. Conclusion: Low monthly family income, use of drugs, alcohol, or smoking during pregnancy and absence of breastfeeding were more frequent on mothers of preterm infants.

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Section: Discussionmentioning

confidence: 99%

Difference of Socioeconomic Factors among Mothers of Preterm and Full-Term Infant

Carcavalli

Rocha

Valentim

et al. 2020

Pesqui. Bras. Odontopediatria Clín. Integr.

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“…The prevalence of intoxicated children by crack cocaine increased (dos Santos et al, 2018), because its metabolites cross the placenta and reach fetal tissues in high concentrations, which might affect child development (Zavaschi et al, 2014). The negative effect of crack cocaine do not depend on the dose, suggesting that any exposure levels increase the risk to newborn (White & Lambe, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, crack cocaine effects in utero are very different for each newborn (Mardini et al, 2017;Parcianello et al, 2018) and the exposure impact may continue after birth, resulting in long-term effects on the child's organism (dos Santos et al, 2018;Jones, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…The results show innumerous negative outcomes for newborn health. Concerning the common physiological outcomes, low birth weight (Aghamohammadi & Zafari, 2016;Bateman, Ng, Hansen, & Heagarty, 1993;Behnke et al, 2001;Bender et al, 1995;R Cherukuri, Minkoff, Feldman, A, & Glass, 1988;Radha Cherukuri, Howard, Parekh, Feldman, & Glass, 1987;Fiocchi & Kingree, 2001;Leblanc, 1987;Mardini et al, 2016Mardini et al, , 2017Parcianello et al, 2018;Sprauve, Lindsay Michael K., Herbert, & Graves, 1997;Zavaschi et al, 2014) preterm delivery (Aghamohammadi & Zafari, 2016;Bateman et al, 1993;Behnke et al, 2001;R Cherukuri et al, 1988;Radha Cherukuri et al, 1987;Eyler et al, 1998;Fiocchi & Kingree, 2001;Leblanc, 1987;Reis & Loureiro, 2015;Sprauve et al, 1997;Xavier et al, 2017) and small for gestational age (Behnke et al, 2001;Leblanc, 1987;Reis & Loureiro, 2015) were well establish risk between newborn exposure to crack cocaine during pregnancy (dos Santos et al, 2018). The low 5-minute Apgar score (Parcianello et al, 2018;Sprauve et al, 1997) and small head circunference (Behnke et al, 2001;R Cherukuri et al, 1988;Radha Cherukuri et al, 1987;Leblanc, 1987) were also reported as a risk to crack cocaine exposure.…”

Section: Discussionmentioning

confidence: 99%

“…It is obtained by the conversion of hydrochloride form back into alkalinized form. Crack cocaine may be a more dangerous form of cocaine (dos Santos et al, 2018). There are several psychotropic and neurotoxic effects of crack cocaine use, because of products generated from cocaine pyrolysis (Garcia et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Newborn outcomes exposure to crack cocaine during pregnancy: a critical review

Silveira

Santos

Tavella

et al. 2020

BJD

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Crack cocaine is a psychotropic and neurotoxic drug with high prevalence of consumption, considerate a public health problem and identified as risk factors to human health. Crack cocaine use among women in reproductive age increased in few year and the literature of the neonatal exposure to this substance during pregnancy are limited. Thus, this critical review discusses the major newborn outcomes reported in original studies, highlighting neurologic abnormalities and malformations outcomes. Sixteen studies were included in this review. The main physiological outcome found in newborn exposure to crack cocaine during gestation were lower birth weight; preterm birth; growth restricted infants; lower 5-minute Apgar scores; small for gestational age; and, small head circumference and congenital malformations. There were several negative neurologic and outcomes were reported on the literature. Moreover, there were still no consensus and the main criticism in this area is the limited studies available. RESUMOO crack é uma droga psicotrópica e neurotóxica, com alta prevalência de consumo, considerado um problema de saúde pública e tido como fator de risco para a saúde humana. O uso de crack entre mulheres em idade reprodutiva aumentou em poucos anos e a literatura sobre a exposição neonatal a essa substância durante a gravidez é limitada. Assim, esta revisão crítica discute os principais desfechos neonatais relatados em estudos originais, destacando como desfechos as anormalidades neurológicas e as malformações. Dezesseis estudos foram incluídos nesta revisão. Os principais desfechos fisiológicos encontrados na exposição do recém-nascido ao crack durante a gestação foram menor peso ao nascer; nascimento prematuro; restrição de crescimento; menores escores de Apgar no 5º minuto; pequeno para a idade gestacional; menor circunferência da cabeça e malformações congênitas. Houve vários desfechos neurológicos negativos e os resultados foram relatados na literatura. Ainda assim, não houve consenso na literatura e as principais críticas nesta área são os limitados estudos disponíveis.Palavras-chave: drogas ilícitas, gestação, recém-nascido.

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Future Directions to Support People with Intellectual Disabilities

Shaw

Jankowska

2018

Pediatric Intellectual Disabilities at School

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Maternal, fetal and neonatal consequences associated with the use of crack cocaine during the gestational period: a systematic review and meta-analysis

Abstract: This analysis provides clear evidence that crack cocaine contributes to adverse perinatal outcomes. The exposure of maternal or prenatal crack cocaine is pointedly linked to LBW, preterm delivery, placental displacement and smaller head circumference.

Cited by 52 publications

References 120 publications

Difference of Socioeconomic Factors among Mothers of Preterm and Full-Term Infant

Difference of Socioeconomic Factors among Mothers of Preterm and Full-Term Infant

Newborn outcomes exposure to crack cocaine during pregnancy: a critical review

Future Directions to Support People with Intellectual Disabilities

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