Maternal-fetal distribution of methaqualone in control and SKF 525-A-pretreated pregnant mice

Effects of Mandrax and Cannabis on the cellular function of chick embryonic neurons

“…For this reason only the total amount of freeze-dried material was determined and all data were reported as such. Shah et al, 1977, observed that orally administered MTQ in rats resulted in MTQ being uniformly distributed in various brain regions, due to the lipophilic nature of this drug (Shah et al, 1977 andShah, 1978). Due to the high lipophilic nature of the myelin sheath, MTQ accumulates at this specific site, serving as a reservoir for MTQ openUP with its eventual effect on the cells of the brain.…”

Age-Dependent Variations in the Distribution of Methaqualone in Rat

“…The animals were randomly divided irrespective of the sex. In a previous study, we found the lack of influence of sex on the pattern of distribution of MTQ (19). The following age-groups of animals with their mean body weights in parentheses were used: day 1 (6 g), day 4 (10 g), day 8 (19 g), day 12 (28 g), day 20 (44 g), and day 60 (250 g); each experiment contained 3-4 animals.…”

“…All data are reported as microgram per gram of wet weight tissue or per milliliter of plasma. The procedure employed for the extraction of unchanged MTQ was fairly specific as determined by thin-layer chromatography (19). …”

“…14 Methaqualone (MTQ) is a clinically effective, nonbarbiturate sedativehypnotic and anticonvulsant agent which has risen high on the list of abused drugs. The physiological disposition of this drug was extensively studied chiefly in adults, both humans and several animal species (1,5,6,19,22). Considerable variations in the distribution and metabolism of a wide range of drugs have been demonstrated in immature versus mature hosts (4,8,10,16,21).…”