Maternal-fetal hemorrhage: Its incidence and sensitizing effects

Jennings, E. R.; Clauss, Barbara

doi:10.1016/0002-9378(78)90234-x

Cited by 24 publications

(18 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in accordance with previous studies [6,8] and with the conclusions of Helderweirt's [5] pioneer work. Given the low frequency of the event, a further study on a larger sample of neonates would be necessary in order to better describe the frequency and the volumes' extent of MFH, and to determine the influence of some obstetric var iables, mainly cesarean section, on the occurrence of this event.…”

Section: Mother To Fetus Transfer Of Red Blood Cellssupporting

confidence: 83%

“…The first work on MFH in human pregnancy was performed in 1946 by Naeslund and Nylind [1] who injected 32P-tagged RBCs into pregnant women. Since that time, several studies based on microagglutination or immunofluorescent techniques have confirmed the presence of maternal erythrocytes in neona tal blood, but wide differences were noted in the frequency of MFH; while two studies reported a low frequency (1.8% [6] and 1.9% [8]), others indicated a much higher incidence (58% [7] and between 2.2 and 70% [5]). In these studies the percentage of maternal RBCs was generally well under 1% but the volumes of MFH were poorly defined.…”

Section: Mother To Fetus Transfer Of Red Blood Cellsmentioning

confidence: 99%

“…Apparently no recent work has been pub lished on that subject and there has been no study on obstet ric factors associated with the occurrence of MFH. Recent ly, studies [9,1()] on placental blood collected for cord blood banks have looked at contaminations with maternal leuko cytes; however, these studies are only partially relevant for the present purpose because of the well-known postdelivery contamination of cord blood with maternal cells [8,11].We report here a preliminary study on the incidence of MFH and its possible association with obstetric parameters, and we describe the methodological improvements for the diagnosis and quantitation of maternal RBCs in the blood of neonates. …”

mentioning

confidence: 99%

See 2 more Smart Citations

Maternal-Fetal Hemorrhage: A Reappraisal

Brossard¹,

Pons²,

Jrad³

et al. 1996

Vox Sanguinis

View full text Add to dashboard Cite

To determine the frequency of maternal-fetal hemorrhage at or above 1 μl of maternal whole blood. Methods: Seventy-three mothers whose red blood cells bore an Rh antigen (Rh D, Rh c, Rh E) that was absent on red blood cells of their newborns were identified and a new cytological method, the Kleihauerimmunogold- silver-staining technique, was applied on the blood of their neonates to detect and quantify maternal red blood cells. Stringent precautions were taken to avoid contaminations of neonatal blood samples by adult red blood cells. Results: Maternal red blood cells were present in 3 newborns, a frequency of 4% (95% Cl: 1-11%), and the estimated volumes of hemorrhage were 0.8, 1.5, and 101 μl of maternal whole blood. No obstetric factor was clearly associated in this limited study with the occurrence of maternal-fetal hemorrhage. Conclusions: Mother-to-fetus microtransfusion greater than 1 μl is infrequent at or near delivery, and it may be observed after an uncomplicated pregnancy and vaginal delivery.

show abstract

Section: Mother To Fetus Transfer Of Red Blood Cellssupporting

confidence: 83%

Section: Mother To Fetus Transfer Of Red Blood Cellsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Maternal-Fetal Hemorrhage: A Reappraisal

Brossard¹,

Pons²,

Jrad³

et al. 1996

Vox Sanguinis

View full text Add to dashboard Cite

show abstract

“…Theories regarding the role of placental tissue in HIV transmission focus on the syncytiotrophoblast, which is believed to have a placental barrier function, and recent findings suggest that the trophoblast may take part in the transplacental transmission of HIV (Maury et al, 1989;Lewis et al, 1990). However, there may be routes that bypass the trophoblast barrier; these may be associated somehow with maternal-foetal haemorrhages (Desai & Creger, 1963;Jennings & Clauss, 1978).…”

Section: Introductionmentioning

confidence: 99%

Susceptibility of cultured human trophoblasts to infection with human immunodeficiency virus type 1

Zachar

Nørskov‐Lauritsen

Juhl

et al. 1991

Journal of General Virology

View full text Add to dashboard Cite

Primary cultures of essentially pure human term trophoblasts were studied to determine their ability to support the expression of complete proviral clones of human immunodeficiency virus (HIV) and their permissiveness to this virus. Transient expression of molecular clones derived from two biologically distinct strains, BRU and NDK, resulted in the release of comparable amounts of infectious virions, which were rescued by cocultivation with permissive CEM-SS cells. Trophoblasts were inoculated with three HIV-1 isolates, RF, 3B and NDK, which differ in their cytopathogenicity on T lymphoblastoid cells. Infection of cells by all three strains was demonstrated by the presence of virus-specific proteins in the trophoblasts and the detection of virus gag gene-related DNA sequences by the polymerase chain reaction (PCR), but cells were more susceptible to infection with the RF and NDK strains than with the 3B strain. The virus was readily transmitted to the CEM-SS cells with simultaneous formation of syncytia between the two cell types. Flow cytometry and direct radioimmunoassay revealed no trace of the CD4 receptor on the surface of the cultured trophoblasts and CD4 mRNA could not be detected by Northern blot hybridization, although a minimal amount of CD4-associated mRNA was detected by PCR. Our data suggest that infection of trophoblasts occurs independently of the pathway mediated by CD4.

show abstract

“…The possibility of maternal fetal transfer of Rh(D)-positive red cells late in pregnancy and at delivery into the circulation of an Rh(D)-negative fetus or infant, with subsequent Rh antibody development ('The Grand mother Theory') has been reported by some authors [6][7][8], but has not been confirmed by others [9,10] In our experience, only in 3 out of 8 cases (37%) where an Rh(D)-negative woman became Rh-immunized dur ing pregnancy [ 12] and in 6 out of 12 cases (50%) where an Rh(D)-negative woman became Rh-immunized despite antepartum and postpartum Rh prophylaxis (Rh labora tory unpublished data), were the mothers Rh(D)-positive. These statistics lend support to the belief that Rh immu nization due to transplacental passage of maternal Rh(D)-positive cells to the fetus must be very rare if it occurs at It is our opinion that Mrs. S.E.…”

Section: Discussionmentioning

confidence: 99%