2023
DOI: 10.1161/hypertensionaha.123.21568
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Maternal First-Trimester Alpha-Fetoprotein and Placenta-Mediated Pregnancy Complications

Nir Melamed,
Nanette Okun,
Tianhua Huang
et al.

Abstract: BACKGROUND: Maternal serum markers used for trisomy 21 screening are associated with placenta-mediated complications. Recently, there has been a transition from the traditional first-trimester screening (FTS) that included PAPP-A (pregnancy-associated plasma protein-A) and beta-hCG (human chorionic gonadotropin), to the enhanced FTS test, which added first-trimester AFP (alpha-fetoprotein) and PlGF (placental growth factor). However, whether elevated first-trimester AFP has a similar association wi… Show more

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Cited by 5 publications
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“…While there is no doubt about the utility of AFP results from second-trimester studies in this regard, the usefulness of first-trimester results raises doubts. According to studies by Hu et al and Melamed et al, elevated AFP values in the first trimester of pregnancy are not useful as standalone diagnostic markers for adverse pregnancy outcomes (APOs) and should not lead to excessive obstetric surveillance [66,67].…”
Section: Discussionmentioning
confidence: 99%
“…While there is no doubt about the utility of AFP results from second-trimester studies in this regard, the usefulness of first-trimester results raises doubts. According to studies by Hu et al and Melamed et al, elevated AFP values in the first trimester of pregnancy are not useful as standalone diagnostic markers for adverse pregnancy outcomes (APOs) and should not lead to excessive obstetric surveillance [66,67].…”
Section: Discussionmentioning
confidence: 99%