Maternal Food Restriction during Pregnancy and Lactation Adversely Affect Hepatic Growth and Lipid Metabolism in Three-Week-Old Rat Offspring

Lee, Sangmi; You, Young Ah; Kwon, Eun Jin; Jung, Sung Chul; Jo, Inho; Kim, Young Ju

doi:10.3390/ijms17122115

Cited by 21 publications

(12 citation statements)

References 33 publications

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“…Other studies have also demonstrated that IUGR can up-regulate the mRNA expressions of a key transcription factor (Srebp1c) (and its downstream genes), and down-regulate the mRNA expressions of the fatty acid oxidation gene (Ppara), ultimately causing liver lipid metabolism disorder [46]. Lee et al [47] found that IUGR, induced by maternal nutrition restriction, increased the protein expressions of SREBP1 and FASN. These results suggest that the abnormal lipid metabolism in the IUGR piglets was associated with related gene regulation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Curcumin on Growth Performance, Inflammation, Insulin level, and Lipid Metabolism in Weaned Piglets with IUGR

Zhao

et al. 2019

Animals

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The possible causes of intrauterine growth retardation (IUGR) might stem from placental insufficiency, maternal malnutrition, inflammation in utero, and other causes. IUGR has had an adverse influence on human health and animal production. Forty weaned piglets with normal birth weights (NBWs) or IUGR were randomly divided into four treatments groups: NBW, NC (NBW with curcumin supplementation), IUGR, and IC (IUGR with curcumin supplementation) from 26 to 50 d. Levels of cytokines, glucose, and lipid metabolism were evaluated. IUGR piglets showed slow growth during the experiment. Piglets with IUGR showed higher levels of serum pro-inflammatory cytokines, insulin resistance, and hepatic lipid accumulation. Curcumin supplementation reduced the production of serum pro-inflammatory cytokines, attenuated insulin resistance and hepatic triglyceride, and enhanced the hepatic glycogen concentrations and lipase activities of IUGR piglets. The hepatic mRNA expressions of the insulin-signaling pathway and lipogenic pathway were influenced by IUGR and were positively attenuated by diets supplemented with curcumin. In conclusion, IUGR caused slow growth, insulin resistance, and increased hepatic lipid levels. Diets supplemented with curcumin improved growth, attenuated insulin resistance, and reduced lipid levels in the liver by regulating the hepatic gene expressions of the related signaling pathway in IUGR piglets.

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Section: Discussionmentioning

confidence: 99%

Effect of Curcumin on Growth Performance, Inflammation, Insulin level, and Lipid Metabolism in Weaned Piglets with IUGR

Zhao

et al. 2019

Animals

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“…The effects of maternal malnutrition during pregnancy have been intensively studied in the lite rature. These studies have proven the metabolic imprinting (or fetal programming) theory, in which the effects caused during the intra-uterine life may induce metabolic disturbances in later periods [19][20][21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Maternal undernutrition during lactation leads to reduction in skull size and thickness of adult-aged Wistar rats

et al. 2021

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Introduction: It is known that the quality and quantity of milk is directly related to the dietary habits of the mother. Despite that, the rates of maternal malnutrition during lactation are increasing in several countries; thus, observing its effects on the offspring is relevant. The present study aims to verify the effects of maternal malnutrition during breastfeeding on the skulls of adult-aged Wistar rats. Material and methods: Thirty-six newborn rats were divided in three groups: the control group, in which the mother received a regular commercial diet containing 23% protein in unlimited amounts; the protein-energy restriction group, in which the dam received a commercial diet containing 8% protein in unlimited amounts; the energy restricted group, in which the dam received a commercial diet containing 23% of protein in limited amounts. After weaning, all rats received the same diet as the control group until 180 days of age. Then, the rats were euthanized, and their crania were excised and measured in radiographic images. Afterwards, their skull was decalcified with nitric acid (5%) and histological samples were obtained and the thickness of the diploe was verified. Descriptive statistics and ANOVA followed by the Newman-Keuls test were performed for comparison purposes. Results: It was observed that the skull from the protein-energy restriction and energy-restriction groups was smaller and thinner than that of the control group in several parameters. Conclusions: Maternal malnutrition during the lactation period caused longterm effects in skull morphology of Wistar rats. These effects could not be reversed after regulation of the diet.

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“…Under these circumstances, the pups which were breastfed by a malnourished mother had an underdevelopment of multiple bones, such as the tibia, mandible, cranium and femur (Fernandes et al, 2007;Fernandes et al, 2008;Degani Junior et al, 2011;Babinski et al;Luna et al;Confortim et al). Moreover, the maternal malnutrition during the gestational period has also been shown to cause detrimental effects on its offspring (Alippi et al, 2002;Lee et al, 2016;Confortim et al).…”

Section: Discussionmentioning

confidence: 99%

The Cortical Matrix of Femur in Adult-Aged Wistar Rats is Critically Affected by Maternal Malnutrition During Lactation Period

et al. 2018

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Osteoporosis is associated with poor dietary habits. Malnutrition is characterized as a deficit on the intake of necessary nutrients that are essential for optimal health maintenance. It is known that malnutrition during the lactation period can affect the offspring. The present study aims to evaluate the chronic effects caused by maternal energy-protein restriction during lactation period in the offspring. At parturition, Wistar rat dams were divided in three groups: (1) Control group (C)-which received a 23 % protein diet without restrictions; (2) Protein-Energy restriction group (PER)-which received a 8 % protein diet; (3) Energy restriction group (ER)which received a 23 % protein diet in limited amounts, according to the ingestion of the second group. Each group had 12 pups. After weaning, all pups received free access to a 23 % protein diet until 180 days and then were euthanized. Their femur was excised, decalcified, histologically processed and analyzed under a microscope. The measurements of the osteon lacunae on the C, ER and PER groups were, respectively: 2.1 µm, 10.9 µm and 14.7 µm (p<0.05). A poor ingestion of proteins and calories during lactation period provoked critical and permanent changes on the bone matrix of the femur, which simulated osteoporosis.

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Maternal Food Restriction during Pregnancy and Lactation Adversely Affect Hepatic Growth and Lipid Metabolism in Three-Week-Old Rat Offspring

Cited by 21 publications

References 33 publications

Effect of Curcumin on Growth Performance, Inflammation, Insulin level, and Lipid Metabolism in Weaned Piglets with IUGR

Effect of Curcumin on Growth Performance, Inflammation, Insulin level, and Lipid Metabolism in Weaned Piglets with IUGR

Maternal undernutrition during lactation leads to reduction in skull size and thickness of adult-aged Wistar rats

The Cortical Matrix of Femur in Adult-Aged Wistar Rats is Critically Affected by Maternal Malnutrition During Lactation Period

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