Maternal gestational diabetes mellitus: is it associated with long-term pediatric ophthalmic morbidity of the offspring?

Walter, Eyal; Tsumi, Erez; Wainstock, Tamar; Spiegel, Efrat

doi:10.1080/14767058.2018.1439918

Cited by 15 publications

(8 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, children descending from GDM complicated pregnancies were also reported to have an increased risk of paediatric ophthalmic morbidity [ 44 ]. Moreover, a small risk of childhood asthma was observed after exposure to GDM requiring medication only [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

Substantially Altered Expression Profile of Diabetes/Cardiovascular/Cerebrovascular Disease Associated microRNAs in Children Descending from Pregnancy Complicated by Gestational Diabetes Mellitus—One of Several Possible Reasons for an Increased Cardiovascular Risk

Hromadníková

Dvořáková

Krofta

et al. 2020

Cells

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM), one of the major pregnancy-related complications, characterized as a transitory form of diabetes induced by insulin resistance accompanied by a low/absent pancreatic beta-cell compensatory adaptation to the increased insulin demand, causes the acute, long-term, and transgenerational health complications. The aim of the study was to assess if alterations in gene expression of microRNAs associated with diabetes/cardiovascular/cerebrovascular diseases are present in whole peripheral blood of children aged 3–11 years descending from GDM complicated pregnancies. A substantially altered microRNA expression profile was found in children descending from GDM complicated pregnancies. Almost all microRNAs with the exception of miR-92a-3p, miR-155-5p, and miR-210-3p were upregulated. The microRNA expression profile also differed between children after normal and GDM complicated pregnancies in relation to the presence of overweight/obesity, prehypertension/hypertension, and/or valve problems and heart defects. Always, screening based on the combination of microRNAs was superior over using individual microRNAs, since at 10.0% false positive rate it was able to identify a large proportion of children with an aberrant microRNA expression profile (88.14% regardless of clinical findings, 75.41% with normal clinical findings, and 96.49% with abnormal clinical findings). In addition, the higher incidence of valve problems and heart defects was found in children with a prior exposure to GDM. The extensive file of predicted targets of all microRNAs aberrantly expressed in children descending from GDM complicated pregnancies indicates that a large group of these genes is involved in ontologies of diabetes/cardiovascular/cerebrovascular diseases. In general, children with a prior exposure to GDM are at higher risk of later development of diabetes mellitus and cardiovascular/cerebrovascular diseases, and would benefit from dispensarisation as well as implementation of primary prevention strategies.

show abstract

Section: Introductionmentioning

confidence: 99%

Substantially Altered Expression Profile of Diabetes/Cardiovascular/Cerebrovascular Disease Associated microRNAs in Children Descending from Pregnancy Complicated by Gestational Diabetes Mellitus—One of Several Possible Reasons for an Increased Cardiovascular Risk

Hromadníková

Dvořáková

Krofta

et al. 2020

Cells

View full text Add to dashboard Cite

show abstract

“…Some children born from complicated pregnancies have already been suffering from severe diseases, such as asthma [31,32], pulmonary hypertension [33][34][35], diabetes mellitus [36], cardiorenal metabolic syndrome [37], chronic kidney diseases [38,39], cardiovascular diseases [40], ophthalmic disorders [41], neurodevelopmental and neuropsychiatric disorders [42][43][44][45][46][47][48][49][50][51], most likely as a result of abnormal fetal programming.…”

Section: Introductionmentioning

confidence: 99%

Association Analysis in Children Born from Normal and Complicated Pregnancies—Cardiovascular Disease Associated microRNAs and the Incidence of Prehypertension/Hypertension, Overweight/Obesity, Valve Problems and Heart Defects

Hromadníková

Krofta

Širc

2020

IJMS

View full text Add to dashboard Cite

The goal was to assess how a history of any kind of pregnancy-related complication altered expression profile of microRNAs played a role in the pathogenesis of diabetes, cardiovascular and cerebrovascular diseases in the peripheral blood leukocytes of children at the age of 3–11 years. The prior exposure to gestational hypertension, preeclampsia, fetal growth restriction, gestational diabetes mellitus, preterm prelabor rupture of membranes or spontaneous preterm birth causes that a significant proportion of children (57.42% to 90.0% specifically) had a substantially altered microRNA expression profile, which might be the origin of a lifelong cardiovascular risk. A total of 23 out of 29 tested microRNAs were upregulated in children born from such complicated gestation. The occurrence of overweight, obesity, valve problems and heart defects even intensified upregulation of microRNAs already present in children exposed to such pregnancy complications. The occurrence of overweight/obesity (miR-92a-3p, and miR-210-3p) and valve problems or heart defects (miR-342-3p) induced microRNA upregulation in children affected with pregnancy complications. Overall, 42.86% overweight/obese children and 27.36% children with valve problems or heart defects had even higher microRNA levels than children with normal clinical findings after complicated pregnancies. In addition, the microRNA expression profile was also able to differentiate between children descending from normal gestation in relation to the occurrence of overweight and obesity. Screening on the base of the combination of 19 microRNAs identified 70.0% overweight/obese children at 90.0% specificity. In general, children after complicated pregnancies, just as children after normal pregnancies, with abnormal findings are at a higher risk of the onset of cardiovascular complications, and their dispensarization, with the aim to implement primary prevention strategies, would be beneficial.

show abstract

“…One study showed no difference in the incidence of endocrine morbidity between young adults born to women with and without GDM ( 83 ). In contrast, the other study observed a higher prevalence of offspring ophthalmic inflammation (0.74% vs. 0.60%) and a 60% higher risk in ophthalmic-related hospitalization among young adults born to women with GDM and treated with medication (metformin, insulin) ( 78 ).…”

Section: Resultsmentioning

confidence: 86%

Gestational Diabetes Mellitus Among Asians – A Systematic Review From a Population Health Perspective

Hu¹,

Tobias²,

Zhang³

2022

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveSince Asians are particularly vulnerable to the risk of gestational diabetes mellitus (GDM), the lifecourse health implications of which are far beyond pregnancy, we aimed to summarize the literature to understand the research gaps on current GDM research among Asians.MethodsWe systematically searched the articles in PubMed, Web of Science, Embase, and Scopus by 30 June 2021 with keywords applied on three topics, namely “GDM prevalence in Asians”, “GDM and maternal health outcomes in Asians”, and “GDM and offspring health outcomes in Asians”.ResultsWe observed that Asian women (natives and immigrants) are at the highest risk of developing GDM and subsequent progression to type 2 diabetes among all populations. Children born to GDM-complicated pregnancies had a higher risk of macrosomia and congenital anomalies (i.e. heart, kidney and urinary tract) at birth and greater adiposity later in life.ConclusionThis review summarized various determinants underlying the conversion between GDM and long-term health outcomes in Asian women, and it might shed light on efforts to prevent GDM and improve the lifecourse health in Asians from a public health perspective.Systematic Review RegistrationProspero, CRD42021286075.

show abstract

Maternal gestational diabetes mellitus: is it associated with long-term pediatric ophthalmic morbidity of the offspring?

Abstract: Gestational diabetes mellitus treated by medication is associated with an increased risk for long-term pediatric ophthalmic morbidity.

Cited by 15 publications

References 26 publications

Substantially Altered Expression Profile of Diabetes/Cardiovascular/Cerebrovascular Disease Associated microRNAs in Children Descending from Pregnancy Complicated by Gestational Diabetes Mellitus—One of Several Possible Reasons for an Increased Cardiovascular Risk

Substantially Altered Expression Profile of Diabetes/Cardiovascular/Cerebrovascular Disease Associated microRNAs in Children Descending from Pregnancy Complicated by Gestational Diabetes Mellitus—One of Several Possible Reasons for an Increased Cardiovascular Risk

Association Analysis in Children Born from Normal and Complicated Pregnancies—Cardiovascular Disease Associated microRNAs and the Incidence of Prehypertension/Hypertension, Overweight/Obesity, Valve Problems and Heart Defects

Gestational Diabetes Mellitus Among Asians – A Systematic Review From a Population Health Perspective

Contact Info

Product

Resources

About