Maternal haloperidol therapy associated with dyskinesia in a newborn

Collins, Kristine O.; Comer, Joyce B.

doi:10.1093/ajhp/60.21.2253

Cited by 26 publications

(14 citation statements)

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“…Despite their classification as C, haloperidol and chlorpromazine have shown to be helpful in this condition and appear to be safe in low dosages 13. There have been several reports of dyskinesias or other extrapyramidal symptoms in infants born to mothers who received haloperidol during pregnancy 14–16. Haloperidol is recommended by the American Academy of Pediatrics over other neuroleptics, however, because it has less maternal anticholinergic, hypotensive, and antihistaminergic effects 17.…”

Section: Choreamentioning

confidence: 99%

Outcome of patients with early T1 and T2 squamous cell carcinoma of the base of tongue managed by conventional surgery with adjuvant postoperative radiation

et al. 2012

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Section: Choreamentioning

confidence: 99%

Outcome of patients with early T1 and T2 squamous cell carcinoma of the base of tongue managed by conventional surgery with adjuvant postoperative radiation

et al. 2012

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“…These medications have a minimal teratogenic risk (34) and are not expected to cause more adverse effects such as orthostatic hypotension, sedation, tachycardia, or constipation (35) compared to second-generation antipsychotics. When used during pregnancy, their adverse effects include premature labor and low birth weight of the child (36), as well as the occurrence of neonatal dyskinesia (37) and jaundice (38).…”

Section: Therapy Of Peripartum Psychosismentioning

confidence: 99%

Therapy of peripartum mental disorders

Stanković¹,

Stojanov²,

Antonijević³

2019

Acta fac medic Naissensis

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S U M M A R YDuring the peripartum period, women are at a greater risk of developing a mental disorder or experiencing an exacerbation of the pre-existing mental disorders. Therapeutic interventions are based primarily on psychotherapy, but if the symptoms are severe and pose a risk to the mother and the child, then the use of drugs, hospitalization or electroconvulsive therapy is considered. Cognitive-behavioral psychotherapy is the first line of treatment in postpartum blues and postpartum depression, panic disorder, generalized anxiety disorder, and mild to moderate obsessive-compulsive disorder. More recent conceptions regarding the use of drugs during the postpartum period indicate that medications should be prescribed if the risk of using them is lower than the risk of complications caused by the symptoms of mental disorders. Nortriptyline or desipramine are recommended from the group of tricyclic antidepressants, but newer generation antidepressants are shown to be safer during pregnancy. Fluvoxamine, paroxetine and sertraline can be used in postpartum period during breastfeeding, while fluoxetine and citalopram should be avoided. The use of first-generation antipsychotics haloperidol and trifluoperazine is recommended in the antepartum period, during which some of second-generation antipsychotics such as quetiapine, olanzapine, risperidone and aripiprazole can also be used. Clozapine should be avoided during breast-feeding. The use of mood stabilizers during pregnancy requires a thorough knowledge of the recommendations, and it is not advised to use them during the postpartum if the patient is breastfeeding. From the group of benzodiazepines, it is recommended to uselorazepam. Every form of therapeutic approach has proven to be more effective in the presence of emotional support from partners and other family members.

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“…[26][27][28][29][30][31] Valproate is by far the most teratogenic medication used in bipolar disorder; 32 high dose folate (4-5 mg daily) has been recommended 30 but may not necessarily lower this risk; valproate (but not lamotrigine) lowers intelligence scores in young children exposed to it in utero 33 Carbamazepine is associated with increased spina bifida and (late in pregnancy) vitamin K deficiencies Lithium has fewer malformation risks than valproate or carbamazepine, but Ebstein's abnormality occurs in up to 1 in 1000 pregnancies: a low absolute risk but up to Â20 the base rate 34 Although the safety of antipsychotics in pregnancy has not been firmly established (due to many limitations in the studies), they seem relatively safe 29 The SGAs that cause weight gain appear to increase risk of gestational metabolic complications (e.g., diabetes and babies large for gestational age); olanzapine may be associated with low and high birth weight, and a small risk of malformation (e.g., hip dysplasia, meningocele, ankyloblepharon, and neural tube defects)…”

Section: Comorbid Conditions Evidence Considerations a Recommendationsmentioning

confidence: 99%

The Psychopharmacology Algorithm Project at the Harvard South Shore Program

Mohammad

Osser

2014

Harvard Review of Psychiatry

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This new algorithm for the pharmacotherapy of acute mania was developed by the Psychopharmacology Algorithm Project at the Harvard South Shore Program. The authors conducted a literature search in PubMed and reviewed key studies, other algorithms and guidelines, and their references. Treatments were prioritized considering three main considerations: (1) effectiveness in treating the current episode, (2) preventing potential relapses to depression, and (3) minimizing side effects over the short and long term. The algorithm presupposes that clinicians have made an accurate diagnosis, decided how to manage contributing medical causes (including substance misuse), discontinued antidepressants, and considered the patient's childbearing potential. We propose different algorithms for mixed and nonmixed mania. Patients with mixed mania may be treated first with a second-generation antipsychotic, of which the first choice is quetiapine because of its greater efficacy for depressive symptoms and episodes in bipolar disorder. Valproate and then either lithium or carbamazepine may be added. For nonmixed mania, lithium is the first-line recommendation. A second-generation antipsychotic can be added. Again, quetiapine is favored, but if quetiapine is unacceptable, risperidone is the next choice. Olanzapine is not considered a first-line treatment due to its long-term side effects, but it could be second-line. If the patient, whether mixed or nonmixed, is still refractory to the above medications, then depending on what has already been tried, consider carbamazepine, haloperidol, olanzapine, risperidone, and valproate first tier; aripiprazole, asenapine, and ziprasidone second tier; and clozapine third tier (because of its weaker evidence base and greater side effects). Electroconvulsive therapy may be considered at any point in the algorithm if the patient has a history of positive response or is intolerant of medications.

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Maternal haloperidol therapy associated with dyskinesia in a newborn

Cited by 26 publications

References 0 publications

Outcome of patients with early T1 and T2 squamous cell carcinoma of the base of tongue managed by conventional surgery with adjuvant postoperative radiation

Outcome of patients with early T1 and T2 squamous cell carcinoma of the base of tongue managed by conventional surgery with adjuvant postoperative radiation

Therapy of peripartum mental disorders

The Psychopharmacology Algorithm Project at the Harvard South Shore Program

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