Maternal HBsAg carrier and pregnancy outcome

Aghamohammadi, Azar; Zafri, Mandana

doi:10.1016/j.jceh.2013.03.087

Cited by 5 publications

(19 citation statements)

References 12 publications

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“…15 Another study found that carrier HBsAg women had higher risk to become preterm labor. 16 However, Wong et al research didn't find any association between HBV infection in maternal patients with preterm labor, same as this research results in Dr. Soetomo General Hospital. 17 Based on the occupation as seen in figure 1, the most frequent occupation of maternal patients was housewife (13 patients), followed by private employees (10 patients).…”

Section: Methodssupporting

confidence: 64%

PROPORTION OF HBsAg AND HBeAg POSITIVE IN MATERNAL PATIENTS AND THEIR HBsAg POSITIVES BABIES WITH IMMUNOPROPHYLAXIS OF HBV IMMUNIZATION IN Dr. SOETOMO GENERAL HOSPITAL, SURABAYA

Tanadi

Lusida

Joewono

2017

IJTID

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Hepatitis B Virus (HBV) can be transmitted vertically from mother to her baby. Mothers with HBsAg and HBeAg positives have more risk of transmitting HBV to her baby rather than HBsAg positives only. The aim of this study is to determine the proportion of maternal patient with HBsAg and HBeAg positives and their HBsAg positives babies with immunoprophylaxis of HBV immunization. This study was performed by analytical observation using medical records in 2013-2014 at Obstetric and Gyn ecology

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Section: Methodssupporting

confidence: 64%

PROPORTION OF HBsAg AND HBeAg POSITIVE IN MATERNAL PATIENTS AND THEIR HBsAg POSITIVES BABIES WITH IMMUNOPROPHYLAXIS OF HBV IMMUNIZATION IN Dr. SOETOMO GENERAL HOSPITAL, SURABAYA

Tanadi

Lusida

Joewono

2017

IJTID

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“…After screening the title and abstract, 88 reports were potentially eligible. Finally, 23 studies, including 21 full reports and two conference abstracts published after 1999, were eligible after full‐text screening . The flow chart of included studies is presented in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…One study reported as a conference abstract did not report the number of patients included . The majority of studies were conducted in Asia and Oceania (eight in Hong Kong, three in Mainland China, three in Thailand, two in Iran, one in Israel and one in Australia), and the other five were conducted in America and Europe …”

Section: Resultsmentioning

confidence: 99%

Hepatitis B surface antigen positivity during pregnancy and risk of gestational diabetes mellitus: A systematic review and meta‐analysis

Tan

Mao

Zhang

et al. 2018

Journal of Viral Hepatitis

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Chronic hepatitis B virus (HBV) infection is a prevalent public health issue worldwide. Its impact on important pregnancy outcomes, such as gestational diabetes mellitus (GDM), has not been clearly established. The findings from published studies are inconsistent. In this systematic review and meta-analysis, we aimed to clarify whether HBV infection manifested during pregnancy is associated with an increased risk of GDM. We searched MEDLINE and EMBASE for cohort studies and case-control studies that investigated the association between maternal hepatitis B surface antigen (HBsAg) positivity and GDM. We pooled adjusted odds ratio (aOR) and unadjusted OR, respectively, using the random-effect generic inverse variance method. We assessed risk of bias using the Quality in Prognosis Studies tool and conducted five pre-specified subgroup analyses. In total, 23 cohort studies involving 3 529 223 participants were included. The risk of GDM was 6.48% (1868/28 829) among HBsAg-positive pregnant women and 3.41% (119 283/3 500 394) among HBsAg-negative pregnant women. Meta-analyses of both unadjusted and adjusted effect estimates showed that HBsAg positivity during pregnancy was associated with higher risk of developing GDM (unadjusted OR 1.35, 95% CI: 1.17 to 1.56, I = 82.6%; adjusted OR 1.47, 1.22 to 1.76, I = 62%). Among pre-specified subgroup analysis, significant differences were found among studies with high vs low or moderate risk of bias. The results were robust to sensitivity analyses. In conclusion, HBsAg positivity during pregnancy has a moderate effect on an increased risk of GDM. Given the size of the population with HBV infection worldwide, however, this effect could have substantial impact on pregnancy. Further studies are warranted to investigate whether active infection with HBeAg positivity would further elevate the risk of adverse events during pregnancy.

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“…While maternal asymptomatic infection with HBV has been associated with increased antepartum hemorrhage [18][19][20][21]28], gestational diabetes mellitus [10,13,18,28], preterm birth [18][19][20][21][22][23], and fetal growth restriction [20,21,28], one intriguing finding was on the occurrence of preeclampsia. Compared with the generally increasing rates of adverse pregnancy outcomes associated with maternal CHB infection [10-13, 22, 23], several epidemiological studies observed a negative association between CHB infection and preeclampsia [9][10][11], but the limited published studies regarding this issue showed inconclusive and inconsistent results.…”

Section: Discussionmentioning

confidence: 99%

“…However, the limited published studies on this issue have yielded inconclusive and inconsistent results [11,[15][16][17][18][19][20][21][22][23]. Therefore, whether Chronic HBV infection might be associated with a decreased rate of preeclampsia remains an important but unresolved question.…”

Section: Introductionmentioning

confidence: 99%

Chronic Hepatitis B Infection is Associated with Decreased Risk of Preeclampsia: A Meta-Analysis of Observational Studies

Huang

Chen

Zhong

et al. 2016

Cell Physiol Biochem

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Background/Aims: Preeclampsia is a complex multi-system obstetric syndrome and remains one of the leading causes contributing to maternal and perinatal mortality and morbidity. Previous epidemiological studies regarding the association between chronic hepatitis B virus (CHB) infection and the risk of preeclampsia have reported inconsistent results. Therefore, we conducted a meta-analysis to investigate the association between CHB infection and preeclampsia. Methods: The electronic database was searched until January 1st, 2016. Relevant studies reporting the association between CHB infection and the risk of preeclampsia were included and for further evaluation. Statistical analysis was performed using Stata 10.0 (Stata Corp). Results: Three observational cohort studies and eight case-control studies, including 11566 preeclampsia patients, were identified. A significant negative association between CHB infection and preeclampsia was observed (odds ratio = 0.77, 95% confidence interval, 0.65- 0.90, P=0.002, fixed-effect model). Conclusions: Findings from our meta-analysis indicate that CHB infection may decrease the risk of preeclampsia in Asian population. Future prospective cohorts in different countries with larger sample sizes are warranted to ascertain the causality and pathophysiological studies are required to explore the possible biological mechanisms involved.

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Maternal HBsAg carrier and pregnancy outcome

Cited by 5 publications

References 12 publications

PROPORTION OF HBsAg AND HBeAg POSITIVE IN MATERNAL PATIENTS AND THEIR HBsAg POSITIVES BABIES WITH IMMUNOPROPHYLAXIS OF HBV IMMUNIZATION IN Dr. SOETOMO GENERAL HOSPITAL, SURABAYA

PROPORTION OF HBsAg AND HBeAg POSITIVE IN MATERNAL PATIENTS AND THEIR HBsAg POSITIVES BABIES WITH IMMUNOPROPHYLAXIS OF HBV IMMUNIZATION IN Dr. SOETOMO GENERAL HOSPITAL, SURABAYA

Hepatitis B surface antigen positivity during pregnancy and risk of gestational diabetes mellitus: A systematic review and meta‐analysis

Chronic Hepatitis B Infection is Associated with Decreased Risk of Preeclampsia: A Meta-Analysis of Observational Studies

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