<i>Introduction</i>: Efforts have been made to improve maternal and child health care globally, with a focus on promoting postnatal care for mothers and babies. In spite of the known significance of postnatal visits for enhancing maternal and child health care, concerns still exist regarding maternal and infant health care in the Ashanti Region and Ghana as a whole. The study aimed to explore and describe the challenges experienced by community health nurses that may have an impact on postnatal home visitation in selected districts of the Ashanti Region, Ghana. <i>Method</i>: Qualitative research method was used to collect data. Semi-structured interviews were conducted using 15 CHNs. Data were analysed using a thematic content analysis approach. <i>Results</i>: Two main themes and six categories emerged from the overall analysis of the data from the CHNs. One theme emerged based on the objective of the study and the other theme emerged based on the analysis of the responses of the participants. Themes emerged include: challenges of postnatal home visitation and preparation for and responsibilities during postnatal visits. <i>Conclusion</i>: The study concludes that postnatal home visits face significant challenges due to institutional limitations, socio-cultural barriers, and mother-related issues, which can hinder effective care. Additionally, community health nurses (CHNs) strive to provide essential services through preparation, skills application, and ongoing education.