Maternal health, in-utero, and perinatal exposures and risk of thyroid cancer in offspring: a Nordic population-based nested case-control study

Kitahara, Cari M.; Daltveit, Dagrun Slettebø; Ekbom, Anders; Engeland, Anders; Gissler, Mika; Glimelius, Ingrid; Grotmol, Tom; Lagerros, Ylva Trolle; Madanat‐Harjuoja, Laura; Männistö, Tuija; Sørensen, Henrik Toft; Troisi, Rebecca; Bjørge, Tone

doi:10.1016/s2213-8587(20)30399-5

Cited by 12 publications

(6 citation statements)

References 28 publications

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“…In the overall population, a previous history of gout was not related to the occurrence of thyroid cancer in this study. This lack of a significant association between thyroid cancer and pre-existing gout history could partially originate from the contribution of multiple risk factors to the development of thyroid cancer in addition to gout such as metabolic syndrome and cardiovascular diseases [ 19 ]. On the other hand, a few individuals with a history of gout in the middle-aged adult group (<60 years old) and the healthy patient group, which included those with a normal weight and without past medical histories, demonstrated a higher risk of thyroid cancer in our present study.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort

Kim

Yoo

Kwon

et al. 2022

JPM

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In this study, we investigated the risk of thyroid cancer in patients with gout. Participants ≥ 40 years old in the Korean National Health Insurance Service–Health Screening Cohort were investigated. A total of 5844 patients with thyroid cancer were paired with 23,376 comparison participants (no history of thyroid cancer) to build the nested case–control study. A previous history of gout was collected from both the thyroid cancer and comparison participants. The relationship of thyroid cancer with a prior history of gout was analyzed using a conditional logistic regression model. The rate of gout was higher in the patients with thyroid cancer than in the comparison group. In the total study population, the relationship of thyroid cancer with a prior history of gout was not statistically evident. A previous history of gout was related to an increased risk of gout in the < 60 years old, normal weight, abnormal blood pressure, and CCI score = 0 groups. The occurrence of thyroid cancer was not associated with a prior history of gout in the general adult population. However, a prior history of gout was related to an elevated risk of thyroid cancer in middle-aged and healthy populations without comorbidities.

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Section: Discussionmentioning

confidence: 99%

The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort

Kim

Yoo

Kwon

et al. 2022

JPM

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“…Adequate thyroid hormones are vital for the maturation and function of ovarian, uterine, and placental tissue ( 26 ), which are important for optimal pregnancy outcomes and fetal development ( 9 ). Fetuses suffering from intrauterine thyroid dysfunction due to maternal thyroid dysfunction tend to have increased risk of thyroid cancer and impaired physical and cognitive function ( 27 , 28 ). Therefore, we presume that optimal thyroid status at the time of conception may help improve fetal–maternal health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Seasonal Changes of Thyroid Function Parameters in Women of Reproductive Age Between 2012 and 2018: A Retrospective, Observational, Single-Center Study

Guo

et al. 2021

Front. Endocrinol.

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BackgroundThyroid function can be influenced by external stimuli such as light and temperature. However, it is currently unknown whether there is seasonal variation of thyroid function in women of reproductive age. Adequate thyroid function in reproductive-aged women is necessary for optimal fetal–maternal outcomes. Therefore, this study aims to evaluate the seasonal changes in levels of thyrotropin (TSH), free triiodothyronine (FT3), free thyroxine (FT4), and TSH index (TSHI) in women of reproductive age.MethodsA large retrospective study was conducted that included women aged 20–49 years who visited our outpatient or checkup center between 2012 and 2018. Thyroid function was measured using the automated immunochemiluminescent assay kit. Subjects with overt thyroid dysfunction, pregnancy, thyroid disease, cancer, and severe infectious or psychological disease were excluded. Seasonal differences of thyroid function were analyzed using the Kruskal–Wallis test or the analysis of means with transformed ranks. Spearman’s correlation was performed to evaluate the association between thyroid function parameters and age. A subset of 181 subjects was included in the longitudinal analyses. Differences in thyroid function between summer and winter were analyzed using the Wilcoxon signed-rank test.ResultsA total of 48,990 women with a median age of 39 years were included. The prevalence of subclinical hypothyroidism was lower in summer but higher in winter (5.6% vs. 7.0%, p < 0.05). The TSH, FT3, and FT4 levels and TSHI reached a peak in winter, while they declined to trough in summer. The TSH concentrations (r = 0.044, p < 0.001) and TSHI (r = 0.025, p < 0.001) were positively correlated with age, whereas FT3 (r = -0.073, p < 0.001) and FT4 (r = -0.059, p < 0.001) were negatively correlated with age. The associations of thyroid parameters with age were similar between subjects with positive thyroid peroxidase antibody (TPOAb) and those with negative TPOAb. In the matched longitudinal analysis of 181 subjects, no differences were detected in the thyroid parameters between summer and winter.ConclusionsThis retrospective single-center study showed that thyroid hormone levels and central sensitivity to thyroid hormones are influenced by age and seasonal fluctuations among women of reproductive age, while their impact on reproductive health remains to be elucidated in future studies.

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“…Moreover, the prognosis of advanced PTC is still not ideal (4,5). The pathogenesis of PTC is not completely clear, although many risk factors are known to be closely related to the occurrence and development of PTC, such as genetic factors, environmental exposure, and epigenetic changes (6,7). Therefore, it is of great significance to study the molecular mechanism of PTC progression for finding new therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA SNHG6 promotes papillary thyroid cancer cells proliferation via regulating miR-186/CDK6 axis

Xu¹,

Liao²

2021

Gland Surg

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Background: Papillary thyroid cancer (PTC) is a common endocrine malignancy, and its incidence rate has been increasing in recent years. Long noncoding RNAs (lncRNAs) participate in cell biological processes through a variety of regulatory ways, and play an essential role in tumor development.Methods: This study explored the expression of lncRNA small nucleolar RNA host gene 6 (SNHG6) in PTC by bioinformatics analysis, and quantitative real-time PCR (qRT-PCR). Cell counting kit-8 (CCK-8) assay, colony formation assay, and 5-ethynyl-2'-deoxyuridine (EdU) assay were used to study the effect of SNHG6 on the proliferation of PTC cells. Luciferase reporter gene assay and western blot were used to study the mechanism.Results: SNHG6 was highly expressed in PTC tissue samples and cell lines. In vitro, overexpression of SNHG6 promoted the proliferation of PTC cells, while silencing SNHG6 inhibited the proliferation of PTC cells. miR-186 is the downstream target of SNHG6. SNHG6 regulates the proliferation of PTC cells through miR-186. In addition, CDK6 is the target gene of miR-186, which can inhibit the expression of CDK6 protein. SNHG6 can promote the expression of CDK6 by regulating miR-186.Conclusions: SNHG6 is highly expressed in PTC and can promote the proliferation of PTC cells by regulating the miR-186/CDK6 axis, which is expected to become a potential therapeutic target for PTC.

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Maternal health, in-utero, and perinatal exposures and risk of thyroid cancer in offspring: a Nordic population-based nested case-control study

Cited by 12 publications

References 28 publications

The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort

The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort

Seasonal Changes of Thyroid Function Parameters in Women of Reproductive Age Between 2012 and 2018: A Retrospective, Observational, Single-Center Study

Long noncoding RNA SNHG6 promotes papillary thyroid cancer cells proliferation via regulating miR-186/CDK6 axis

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