Maternal hemochromatosis gene H63D single-nucleotide polymorphism and lead levels of placental tissue, maternal and umbilical cord blood

Kayaaltı, Zeliha; Kaya-Akyüzlü, Dilek; Söylemezoğlu, Tülın

doi:10.1016/j.envres.2015.05.004

Cited by 12 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most related genes affecting lead toxicokinetics are delta-aminolevulinic acid dehydratase (ALAD) gene, Vitamin D receptor (VDR) gene and human hemochromatosis gene (HFE) [2,33,34]. The genetic polymorphisms in VDR gene are associated with lead toxicity due to the relationship between Ca 2þ and Pb 2þ .…”

Section: Discussionmentioning

confidence: 99%

Does maternal VDR FokI single nucleotide polymorphism have an effect on lead levels of placenta, maternal and cord bloods?

et al. 2015

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Does maternal VDR FokI single nucleotide polymorphism have an effect on lead levels of placenta, maternal and cord bloods?

et al. 2015

Self Cite

View full text Add to dashboard Cite

“…Although the precise mechanisms through which heavy metals actively cross the placental barrier remain unclear, it is likely that these otherwise foreign trace metals usurp the roles of evolutionarily conserved methods for the transfer of essential elements to the developing fetus. Lead (Pb), for instance, is able to utilize existing mechanisms for Fe homeostasis to disperse throughout the human body, including across the placenta [7,8]. Even excessive exposure to otherwise essential metals can compromise the placental barrier; for example, high manganese (Mn) concentrations have been observed in placental tissues from children with neural tube defects [9].…”

Section: The Placenta As a Window Into Fetal Exposurementioning

confidence: 99%

Multielemental bioimaging of tissues in children's environmental health research

Austin

Niedzwiecki

Arora

2016

Current Opinion in Pediatrics

View full text Add to dashboard Cite

Purpose of review Metals play major roles in children's health and are associated with negative health outcomes via deficiency, overload or toxicity. Constantly evolving analytical technology can provide new insight into how metal metabolism and exposure biology are intertwined in a range of biological matrices. Recent findings Exposure can occur prenatally as many metals cross the placental barrier. The placenta is permeable to many metal species, some through tightly regulated transporters, and others because of a limited capacity for detoxification. Post-birth, metal exposure continues to exert long-term health effects, ranging from exposure to exogenous heavy metals, such as lead, to overload of otherwise essential metals, including manganese. Increasing evidence supports the existence of critical developmental windows when susceptibility to toxicants and nutritional deficiencies is highest. Elemental imaging technology provides micro-spatial information on metal uptake and retention across tissue architecture, which provides important insights into exposure and biologic response. Summary Imaging the spatial distribution of elements, both essential and toxic, provides information that bulk measures cannot, including cell-specific distributions and timing of exposure.

show abstract

“…It is well documented that lead can cause deleterious effects on the reproductive, haematological and cardiovascular systems, neurotoxicity, nephrotoxicity, genotoxicity and embryotoxicity in laboratory animals and humans (Anjum et al, 2011;Kayaalti et al, 2015;Skerfving et al, 2015;Szymańska-Chabowska et al, 2015). Lead exposure is an established cause of chronic kidney disease in adults and children, where adverse associations between blood Pb and kidney function have been observed (lee & Kim, 2012).…”

Section: Introductionmentioning

confidence: 99%

Curative Role of D-Penicillamine versus Combined Garlic and Silymarin Extracts on Lead-Induced Nephrotoxicity and Oxidative Stress in Adult Male Albino Rats

Elkhalek

Ibrahim

2015

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

View full text Add to dashboard Cite

Background Lead (Pb) poisoning is still an important global health problem, especially in developing countries. Lead has been extensively used for many years ago, and it will continue to be used in future. Aim of work: This study was conducted to compare the curative role of D-penicillamine versus combined garlic and silymarin extracts for treating nephrotoxicity in adult male rats exposed to Pb for 3 months. Material and methods: The study was conducted on 70 adult male albino rats divided into 7 groups each of 10 rats, where they received all chemicals by oral gavage. Groups I & II were the negative and positive control rats, respectively. Group III received 25 mg/kg/day D-penicillamine for 1 month (4 th month). Group IV received combined garlic 20 mg/kg/day+ silymarin 200 mg/kg/day for 1 month (4 th month). Group V received 20 mg/kg/day Pb acetate for 3 months. Group VI received Pb acetate for 3 months followed by D-penicillamine for another 1 month, with the previously mentioned doses. Group VII received Pb acetate for 3 months followed by combined garlic & silymarin for another 1 month, with the previously mentioned doses. At the end of the experimental period (4 months), Pb-level in blood, urine & kidney tissue, kidney function tests (blood urea and serum creatinine) and serum malondialdehyde (MDA) & glutathione peroxidase (GSH-Px) were measured. Light microscopic examination of hematoxylin and eosin stained kidney tissue was performed to detect histopathological changes. Results: Lead administration significantly elevated blood lead level (BLL), kidney lead level (KLL), urinary lead level (ULL) and malondialdehyde (MDA), while glutathione peroxidase (GSH-Px) showed significant decrease when compared with the negative control rats. In Pb treated group, histopathological examination of the kidney revealed extensive tubular damage by presence of necrotic epithelial cells, tubular degeneration, necrosis, cell swelling, mononuclear cell infiltration, and degenerated organelles. Kidney functions didn't show any significant differences among all groups. Treatment of rats by D-penicillamine or combined garlic & silymarin extracts resulted in significant decrease in Pb-levels and MDA with a significant increase in blood GSH-PX levels. Also, significant improvement of lead induced histopathological lesions in the kidneys was observed. Combined garlic and silymarin extract treatment showed more significant improvement than D-penicillamine treated Pb-administered groups, in most of the tested parameters. Conclusion: Both D-penicillamine and combined garlic & silymarin extracts can reduce lead induced nephrotoxicity and oxidative stress. Moreover, garlic & silymarin curative effect is better than that of D-penicillamine. Recommendations: Exposure of the population to lead must be controlled. Search for sensitive blood or urinary marker for early detection of kidney damage and further studies are needed to consider a combination of garlic and silymarin is effective in the treatment of lead-induced toxicities.

show abstract

Maternal hemochromatosis gene H63D single-nucleotide polymorphism and lead levels of placental tissue, maternal and umbilical cord blood

Cited by 12 publications

References 30 publications

Does maternal VDR FokI single nucleotide polymorphism have an effect on lead levels of placenta, maternal and cord bloods?

Does maternal VDR FokI single nucleotide polymorphism have an effect on lead levels of placenta, maternal and cord bloods?

Multielemental bioimaging of tissues in children's environmental health research

Curative Role of D-Penicillamine versus Combined Garlic and Silymarin Extracts on Lead-Induced Nephrotoxicity and Oxidative Stress in Adult Male Albino Rats

Contact Info

Product

Resources

About