Maternal hemoglobin level, prematurity, and low birth weight

Yazdani, Maryam; Tadbiri, M; Shakeri, Saeed

doi:10.1016/j.ijgo.2003.07.004

Cited by 14 publications

(16 citation statements)

References 2 publications

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“…Previous studies have shown that maternal anemia is a risk factor for LBW. 37,38 Helminth infections have been recognized as major contributors to anemia in endemic countries. 39,40 In fact, hookworm infection is said to be the most important cause of pathological blood and iron loss in the tropics.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Malaria and Intestinal Helminth Coinfection on Birth Outcomes in Kumasi, Ghana

Yatich¹,

Jolly²,

Funkhouser³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Abstract. This study was conducted to investigate the effect of Plasmodium falciparum and intestinal helminth coinfection on maternal anemia and birth outcomes. A cross-sectional study of 746 women who delivered in two hospitals in Kumasi was conducted. Data were collected using an investigator-administered questionnaire and from patients' medical records. Blood was collected for determination of P. falciparum and hemoglobin levels. Adverse pregnancy outcomes were high (44.6%). Coinfection (versus no infection) was associated with 3-fold increase in low birth weight. For women with anemia, coinfection was 2.6 times and 3.5 times as likely to result in preterm deliveries and small for gestational age infants. The odds of having anemia was increased almost 3-fold by coinfection. Coinfection (versus helminth only) resulted in increased risks of anemia, low birth weight, and small for gestational age infants. This study demonstrates that women with malaria and intestinal helminth coinfection are at particular risk of adverse birth outcomes.

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Section: Discussionmentioning

confidence: 99%

The Effect of Malaria and Intestinal Helminth Coinfection on Birth Outcomes in Kumasi, Ghana

Yatich¹,

Jolly²,

Funkhouser³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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“…Moreover, iron deficiency may increase the risk of maternal infection, which is the main risk factor for preterm birth. Maternal anemia may also increase foetal cortisol production, which is known as an inhibitor of foetal growth (29,38).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, our non-anemic reference group consisted of women with a hemoglobin level of 120 g/l or higher, the level which has been shown to considerably increase the incidence of maternal hypertension and preeclampsia (41). High levels of hemoglobin may also increase the risk of preterm birth and low birth weight, even in the absence of pregnancyinduced hypertension or pre-eclampsia (38).…”

Section: Anemia and Pregnancy Outcomes In Monchegorsk Russiamentioning

confidence: 99%

Anemia in pregnancy and its association with pregnancy outcomes in the Arctic Russian town of Monchegorsk, 1973–2002

Chumak

Grijbovski

2010

International Journal of Circumpolar Health

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Objectives. The purpose of this study was to determine the prevalence of anemia in pregnancy in Monchegorsk, north-west Russia, and to analyse its association with birth weight and the risk of stillbirth and preterm birth. Study design. A registry study based on the Kola Birth Registry. Methods. A total of 24,525 women who gave birth in Monchegorsk between 1973 and 2002 and who had data on anemia in pregnancy in the Kola Birth Registry (KBR) were included in the study. For these women, data on maternal anemia, age, occupation, marital status, parity, smoking, alcohol, gestational age, birth weight, stillbirth and year of delivery were obtained from the KBR. Linear regression was used to study the effect of maternal anemia on birth weight. Logistic regression was used to estimate the effect of anemia on the risks of stillbirth and preterm birth, with adjustment for the above-mentioned characteristics. Crude and adjusted odds ratios (OR) were calculated. Results. The prevalence of anemia increased from 43.7% in the 1970s to 89.8% in the beginning of the 2000s. Infants born to women with anemia were 48 grams (95% CI 36, 59) heavier than infants of non-anemic women. Women with anemia in pregnancy were less likely to have stillbirths (OR=0.68; 95% CI 0.52, 0.89) and preterm births (OR=0.66; 95% CI 0.58, 0.75) after adjustment for potential confounders. Conclusion. The prevalence of anemia in pregnant women as defined by the KBR more than doubled during the 30-year period. Positive associations with birth weight and negative associations with the risk of stillbirth and live preterm birth were observed.

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“…There is an accompanied linear increase in red cell mass of approximately 25-30%, leading to a physiologic anemia of pregnancy. This is reflected in reduced hemoglobin levels, which generally fall through 20 week's gestational age, and remain relatively constant between 20 and 30 weeks gestation before rising slightly near term [1,11,24]. Studies tracking plasma volume, red cell mass and hemoglobin levels indicate the fall of hemoglobin in the first 12 weeks of pregnancy is due to plasma volume expansion, while plasma volume and red cell mass are significantly correlated to hemoglobin concentration during the remainder of pregnancy [12].…”

Section: Discussionmentioning

confidence: 99%

“…However, studies have varied in defining 'high' hemoglobin cutoffs, ranging between 13.3 and 17 g/dl [3,24]. Utilising a z-score for statistical analysis allows for continuous assessment of hemoglobin levels and a robust evaluation of its association with abnormal pregnancy outcome.…”

Section: Discussionmentioning

confidence: 99%

Maternal hemoglobin concentration and its association with birth weight in newborns of mothers with preeclampsia

Amburgey¹,

Ing²,

Badger

et al. 2009

DJMF

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OBJECTIVE Maternal hemoglobin concentration is inversely related to newborn size presumably through plasma volume constriction. We sought to determine whether birth weight would show an inverse relationship to hemoglobin concentration in a group of infants whose mothers had preeclampsia, where plasma volume constriction is common. METHODS Electronic and paper chart review identified 142 nulliparous women with preeclampsia (excluding HELLP syndrome). Birth weight percentile was determined based on cross-sectional hybrid growth curves. Maximal third trimester maternal hemoglobin concentrations were obtained and standardized to z-scores based on gestational age matched normative data. Birth weight percentile was examined as a function of hemoglobin z-score using appropriate statistics. RESULTS Average gestational age at delivery was 35.9±1.9 weeks. Mean birth weight percentile for infants of preeclamptic mothers was 34±32. Mean hemoglobin z-score for mothers with preeclampsia was 0.3±1.5, significantly higher than a control population (p = 0.04). Maternal hemoglobin z-score was inversely associated with birth weight percentile (r = − 0.18, P = 0.03). CONCLUSION Maternal hemoglobin concentrations are significantly elevated prior to delivery in women with preeclampsia. There is a statistically significant inverse correlation of maternal hemoglobin concentration to birth weight percentile.

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Maternal hemoglobin level, prematurity, and low birth weight

Cited by 14 publications

References 2 publications

The Effect of Malaria and Intestinal Helminth Coinfection on Birth Outcomes in Kumasi, Ghana

The Effect of Malaria and Intestinal Helminth Coinfection on Birth Outcomes in Kumasi, Ghana

Anemia in pregnancy and its association with pregnancy outcomes in the Arctic Russian town of Monchegorsk, 1973–2002

Maternal hemoglobin concentration and its association with birth weight in newborns of mothers with preeclampsia

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