Maternal High Triglyceride Levels During Early Pregnancy and Risk of Preterm Delivery: A Retrospective Cohort Study

Lin, Xian Hua; Wu, Dan; Cheng, Li; Xu, Yi; Gao, Ling; Lass, Geffen; Zhang, Jian; Shen, Tian; Ivanova, Deyana; Tang, Lin; Chen, Lei; Ding, Rong; Liu, Xi Mei; Han, Mi; Fan, Jian Xia; Li, Xiao Feng; Sheng, Jian Zhong; O’Byrne, Kevin; Huang, He

doi:10.1210/jc.2018-01372

Cited by 23 publications

(23 citation statements)

References 30 publications

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“…We found concentrations for a set of TGs to be higher and some species of PCs to be lower in prenatal plasma from African American women with PTB compared to those with term birth ( Figure 2C). Our finding is consistent with other reports of high TG levels being associated with an elevated risk of PTB (Lin et al, 2018;Moayeri et al, 2017). Lower PC could be related to higher TG due to poor assembly of lipoproteins, but these findings need further investigation.…”

Section: Lipoproteins and Ptbsupporting

confidence: 93%

“…Specifically, TG(53:5), TG(53:4), TG(54:5), TG(54:6), TG(52:6), and TG(52:4) were positively associated with PTB. Lin et al (2018) also reported that the higher TG levels they found were related to PTB in both overweight and normal-weight women, suggesting that the association is independent of BMI. PCs were found to be in lower levels with PTB and some TG species were found to be higher with PTB.…”

Section: Lipoproteins and Ptbmentioning

confidence: 79%

“…In a recent review of atherogenic lipids in nine cohorts and five case-control studies using standard laboratory assays, women with higher triglyceride (TG) and/or higher homocysteine levels had a higher risk of PTB (Moayeri et al, 2017). A 2018 retrospective cohort study also reported that higher TG levels in early pregnancy were related to PTB (Lin et al, 2018). Two recent studies went beyond standard assays but took a targeted approach to the lipidome.…”

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confidence: 99%

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Lipidome Profiles Are Related to Depressive Symptoms and Preterm Birth Among African American Women

Saadat

Lydic

Misra

et al. 2020

Biological Research For Nursing

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African American women have the highest rate of preterm birth (PTB; <37 completed weeks’ gestation) of any racial and ethnic group in the United States (14.1%). Depressive symptoms (DS) have been linked to PTB risk of African American women. We hypothesized that maternal lipidomic profiles are related to prenatal DS and gestational age at birth among African American women. Women were enrolled at 9–25 weeks’ gestation, completed questionnaires, and provided plasma samples. Lipidomic profiles were determined by “shotgun” Orbitrap high-resolution/accurate mass spectrometry. Data were analyzed using SIMCA P+ software. There was a clear separation in the orthogonal projections to latent structures discriminant analysis score plot between women with Center for Epidemiologic Studies Depression Scale (CES-D) scores ≥23 and women with CES-D scores ≤22. Similarly, a clear separation was observed in the model between PTB and full-term birth. Corresponding S-plot, loading plot, and variable importance in projection plot/list were used to identify the lipids responsible for the groupings. Higher levels of specific triglyceride (TG) species and lower levels of specific phosphatidylcholines (PCs) PC(37:1), PC(41:6), and PC(39:3) were associated with PTB. PC PC(37:1) levels were also lower among women with CES-D scores ≥23, pointing toward a possible connection between DS and PTB. Although overweight pregnant women showed higher levels of TGs, the PTB model showed specific TGs unique to PTB. Lipidomic profiles in pregnant African American women are related to DS, and our data suggest a role for specific TGs and PCs in PTB.

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Section: Lipoproteins and Ptbsupporting

confidence: 93%

Section: Lipoproteins and Ptbmentioning

confidence: 79%

mentioning

confidence: 99%

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Lipidome Profiles Are Related to Depressive Symptoms and Preterm Birth Among African American Women

Saadat

Lydic

Misra

et al. 2020

Biological Research For Nursing

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“…A retrospective study of 49,612 women concluded that high mTG levels during early pregnancy increased the risk of preterm delivery not only among women with overweight and obesity but also among women with normal BMIs. 7 Studies have suggested that high TG levels may be associated with an elevated risk of spontaneous preterm delivery in women. 31 Fetal imprinted genes may influence clinically relevant maternal circulating triglyceride concentrations early in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 Supraphysiological levels of maternal lipids in early or late pregnancy have been shown to be associated with adverse pregnancy outcomes. In early pregnancy, elevated maternal TG (mTG) concentrations are associated with the prevalence rates of preterm birth, [5][6][7] large-for-gestational-age (LGA) newborns, 6 pregnancy-induced hypertension, 6,8 gestational diabetes mellitus (GDM), 9 and preeclampsia. 6,[10][11][12][13][14] In late pregnancy, elevated mTG concentrations are also related to the prevalence rates of pregnancyinduced hypertension, 15 preeclampsia, 11,13,15 GDM, intrahepatic cholestasis of pregnancy, and LGA newborns.…”

Section: Introductionmentioning

confidence: 99%

Association of high maternal triglyceride levels early and late in pregnancy with adverse outcomes: A retrospective cohort study

Xue

Zhou

et al. 2021

Journal of Clinical Lipidology

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BACKGROUND: Excess maternal triglyceride (mTG) exposure during early or late pregnancy increases risks of adverse pregnancy outcomes. However, it is inconclusive whether persistently high maternal triglyceride during whole pregnancy has more negative associations. OBJECTIVE: To explore whether persistently high maternal triglyceride (mTG) levels from early to late pregnancy further increases the risk of adverse pregnancy outcomes. METHODS: We included 12,715 women who had a singleton birth and who underwent routine serum lipid screenings in both early (9-13 weeks) and late (28-42 weeks) pregnancy during May 2018 to July 2019 in a university-based maternity center. Risks for gestational diabetes mellitus (GDM), preeclampsia, preterm delivery, small/large for gestational age (LGA) were estimated. RESULTS: Elevated mTG levels during early pregnancy were associated with increased risks of preterm delivery (AOR, 1.52; 95% CI, 1.21 to 1.90), preeclampsia (1.75; 1.29 to 2.36), gestational diabetes mellitus (1.95; 1.69 to 2.25), and LGA (1.28; 1.12 to 1.46). Compared with those with low mTG levels both in the 1st and 3rd trimesters, persistently high mTG levels increased the risks of preeclampsia (2.53; 1.66 to 3.84), GDM (1.97; 1.57 to 2.47), and LGA (1.68; 1.37 to 2.07). However, persistently high mTG levels only slightly increased risk of LGA when compared with high mTG levels during the 1st trimester alone (1.34, 1.01 to 1.77).

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Establishing reference ranges of serum lipid level during pregnancy and evaluating its association with perinatal outcomes: A cohort study

Zheng

Zhang

Tian

et al. 2021

Intl J Gynecology & Obste

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Objective To establish trimester‐specific reference intervals (TSRIs) for blood lipid profiles in Chinese women and explore their associations with pregnancy outcomes. Methods Participants were women with singleton pregnancies aged 18–45 years without pre‐existing chronic diseases who delivered from January 2018 to December 2018 from an ongoing cohort in Beijing, China. Baseline information and pregnancy outcomes were from the medical records. Blood lipid levels were measured at 7–13, 24–28, and 32–34 weeks of pregnancy. We estimated TSRIs for lipid profiles using an indirect Hoffmann method and evaluated their associations with pregnancy outcomes, including gestational diabetes, pregnancy‐induced hypertension, macrosomia, low birth weight, large or small for gestational age, and preterm delivery. Results The established TSRIs were 3.21–5.38, 4.64–7.56, and 4.86–8.20 mmol/L for total cholesterol; 0.37–1.81, 1.14–3.49, and 1.61–4.63 mmol/L for triglycerides; 1.12–2.19, 1.33–2.49, and 1.24 2.31 mmol/L for high‐density lipoprotein cholesterol; 1.33–2.98,1.97–4.36, and 2.02–4.92 mmol/L for low‐density lipoprotein cholesterol from first trimeseter to third trimester, respectively. Both higher and lower levels of lipid profiles than TSRIs were associated with adverse pregnancy outcomes. Conclusion We suggested TSRIs for blood lipid levels in a Chinese population. Inappropriate lipid levels were associated with adverse pregnancy outcomes.

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Maternal High Triglyceride Levels During Early Pregnancy and Risk of Preterm Delivery: A Retrospective Cohort Study

Cited by 23 publications

References 30 publications

Lipidome Profiles Are Related to Depressive Symptoms and Preterm Birth Among African American Women

Lipidome Profiles Are Related to Depressive Symptoms and Preterm Birth Among African American Women

Association of high maternal triglyceride levels early and late in pregnancy with adverse outcomes: A retrospective cohort study

Establishing reference ranges of serum lipid level during pregnancy and evaluating its association with perinatal outcomes: A cohort study

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