Maternal hyperhomocysteinemia and congenital heart defects: A prospective case control study in Indian population

Malik, R; Lone, Mohd Rafiq; Ahmed, Asif; Koul, Kaisar A.; Malla, Rahid Rasool

doi:10.1016/j.ihj.2016.07.014

Cited by 14 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Genetic and biochemical studies have shown that the preventive effect of folate is through lowering the level of hyperhomocysteinemia, which is a biomarker of oxidative stress and can induce the occurrence of CHD. 16,17 We found that the Hcy level was significantly elevated in the case group, indicating that oxidative stress may have increased in mothers of offspring with CHD.…”

Section: Discussionmentioning

confidence: 75%

High maternal blood lipid levels during early pregnancy are associated with increased risk of congenital heart disease in offspring

Cao

Zhang

et al. 2021

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 75%

High maternal blood lipid levels during early pregnancy are associated with increased risk of congenital heart disease in offspring

Cao

Zhang

et al. 2021

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…Four case control studies (34)(35)(36)(37) reported associations between Neural tube defects and folate, vitamin B12 and homocysteine concentrations in the mother. Two studies reported other congenital anomalies (heart defects, orofacial cleft) (38,39) (Supplementary Table 3).…”

Section: Congenital Anomaliesmentioning

confidence: 99%

“…Maternal hyperhomocysteinemia was associated with increased risk for congenital heart defects (38). A study on risk factors for orofacial clefts (OFC) reported exclusive vegetarianism (proxy for low B12 status) to be a significant risk factor.…”

Section: Observational Studiesmentioning

confidence: 99%

Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India

et al. 2021

View full text Add to dashboard Cite

BackgroundVitamins B12 and folate participate in the one-carbon metabolism cycle and hence regulate fetal growth. Though vitamin B12 deficiency is widely prevalent, the current public health policy in India is to supplement only iron and folic acid for the prevention of anaemia. Prompted by our research findings of the importance of maternal vitamin B12 status for a healthy pregnancy, birth and offspring health outcomes, we evaluated available literature evidence using a systematic review approach, to inform policy.MethodsA systematic search was performed for relevant Indian studies in the MEDLINE/PubMed and IndMed databases. We selected studies reporting maternal vitamin B12 status (dietary intake or blood concentrations), and/or metabolic markers of vitamin B12 deficiency (homocysteine, methylmalonic acid) or haematological indices during pregnancy and their associations with outcomes of pregnancy, infancy or in later life. Intervention trials of vitamin B12 during pregnancy were also included. Quality of evidence was assessed on the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.ResultsOf the 635 articles identified, 46 studies met the inclusion criteria (cohort studies-26, case-control studies-13, RCT’s -7). There is a high prevalence of vitamin B12 deficiency in Indian women during pregnancy (40-70%) (3 studies). Observational studies support associations (adjusted for potential sociodemographic confounders, maternal body size, postnatal factors) of lower maternal B12, higher homocysteine or an imbalance between vitamin B12-folate status with a higher risk of NTDs (6 studies), pregnancy complications (recurrent pregnancy losses, gestational diabetes, pre-eclampsia) (9 studies), lower birth weight (10 studies) and adverse longer-term health outcomes in the offspring (cognitive functions, adiposity, insulin resistance) (11 studies). Vitamin B12 supplementation (7 RCT’s) in pregnancy showed a beneficial effect on offspring neurocognitive development and an effect on birth weight was inconclusive. There is a high quality evidence to support the role of low maternal vitamin B12 in higher risk for NTD and low birth weight and moderate-quality evidence for higher risk of gestational diabetes and later life adverse health outcomes (cognitive functions, risk for diabetes) in offspring.ConclusionIn the Indian population low maternal vitaminB12 status, is associated with adverse maternal and child health outcomes. The level of evidence supports adding vitamin B12 to existing nutritional programs in India for extended benefits on outcomes in pregnancy and offspring health besides control of anaemia.Systematic Review Registration[website], identifier [registration number]

show abstract

“…И наконец, существует теория о влиянии негенетических факторов на развитие ассоциации ВПС и НБ, в частности, пренатальных стрессовых (метаболических) факторов, возможно, имеющих взаимосвязь с увеличением риска формирования ВПС и НБ, -гестационный сахарный диабет, гипергомоцистеинемия [24][25][26][27][28].…”

Section: рисунокunclassified

Association between congenital heart disease and neuroblastoma in children

Shamanskaya¹,

Efimova²,

Kachanov³

et al. 2018

PHOI

View full text Add to dashboard Cite

We have analyzed the association between the most common extracranial solid tumor of childhood neuroblastoma (NB) and congenital heart disease (CHD) based on our own data and literature review. The analyses was carried out based on medical history and echocardiography data of NB patients, who received medical treatment in Dmitriy Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology. 11 out of 457 patients with NB had CHD, the most common diagnosis was ventricular septal defect. The epidemiologic data of the cohort of patients with CHD and NB was presented. The article contains detailed description of two patients with CHD and localized and metastatic NB. The comprehensive analysis of the existing literature was done. In conclusion, CHD was observed in 2,4% cases. All patients with NB are required cardiologic assessment including echocardiography.

show abstract

Maternal hyperhomocysteinemia and congenital heart defects: A prospective case control study in Indian population

Abstract: Increased levels of maternal serum homocysteine are associated with increased risk of occurrence of congenital heart defects in their offsprings, suggesting that maternal hyperhomocysteinemia is an independent risk factor for congenital heart defects.

Cited by 14 publications

References 13 publications

High maternal blood lipid levels during early pregnancy are associated with increased risk of congenital heart disease in offspring

High maternal blood lipid levels during early pregnancy are associated with increased risk of congenital heart disease in offspring

Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India

Association between congenital heart disease and neuroblastoma in children

Contact Info

Product

Resources

About