Maternal hypothyroidism and subsequent neuropsychological outcome of the progeny: a family portrait

Pasquali, Daniela; Carotenuto, Marco; Leporati, Paola; Esposito, Maria; Antinolfi, Lorenzo; Espósito, Daniela; Accardo, Giacomo; Carella, Carlo; Chiovato, Luca; Rotondi, Mario

doi:10.1007/s12020-015-0564-3

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Exclusion criteria were the following: prematurity and/or lower gestation (birth weight), 28 , 29 mental retardation (IQ <70), borderline intellectual functioning (71, IQ <85), 30 , 31 genetic syndromes (eg, down syndrome, Prader–Willi syndrome, and fragile X syndrome), 32 – 34 hypothyroidism, 35 psychiatric disorders (schizophrenia, mood disorders, and attention-deficit hyperactivity disorder [ADHD]), 36 movement disorders, neuromuscular disorders, epilepsy, 37 – 39 and obesity. 40 – 42 …”

Section: Methodsmentioning

confidence: 99%

Visual–spatial training efficacy in children affected by migraine without aura: a multicenter study

Precenzano¹,

Ruberto²,

Parisi³

et al. 2017

NDT

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Routinely in the clinical practice, children affected by migraine without aura (MwA) tend to exhibit severe and persistent difficulties within cognitive processes such as attention, memory, and visual–motor integration (VMI) skills. The aim of this study was to assess the visual–spatial and visual–motor abilities among a sample of children with MwA and the effects of a specific computerized training. The study population was composed of 84 patients affected by MwA (39 girls and 45 boys; mean age: 8.91±2.46 years), and they were randomly divided into two groups (group A and group B) comparable for age (P=0.581), gender (P=0.826), socioeconomic status (SES), migraine frequency (P=0.415), and intensity (P=0.323). At baseline (T0), the two groups were comparable for movement assessment battery for children (M-ABC) and VMI performances. After 6 months of treatment (T1), group A showed lower scores in the dexterity item of M-ABC test (P<0.001) and higher scores in M-ABC global performance centile (P<0.001) and total (P<0.001), visual (P=0.017), and motor (P<0.001) tasks of VMI test than group B. Moreover, at T1, group A showed higher scores in total (P<0.001) and motor (P<0.001) tasks of VMI test and in M-ABC global performance centile (P<0.001) and lower scores in the dexterity item of M-ABC test (P<0.001) than at T0. Group B showed, at T1, performances comparable to T0 for all evaluations. As reported by recent studies about alteration MwA among children in motor abilities, our study confirmed these difficulties and the efficacy of a specific software training, suggesting a new rehabilitative proposal in childhood.

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Section: Methodsmentioning

confidence: 99%

Visual–spatial training efficacy in children affected by migraine without aura: a multicenter study

Precenzano¹,

Ruberto²,

Parisi³

et al. 2017

NDT

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“…TH plays an essential role in normal brain development and its function linked to the maturation of its receptor in the developing brain. On the other hand, hypothalamus plays a crucial role in the regulation of TH serum concentrations, since the earliest stages of life (Alkemade, 2015), also causing specific cognitive alteration in progeny (Pasquali et al, 2015). …”

Section: Orexigenic Systemmentioning

confidence: 99%

Role of the Orexin System on the Hypothalamus-Pituitary-Thyroid Axis

Messina

Fusco

Monda

et al. 2016

Front. Neural Circuits

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Hypocretin/orexin (ORX) are two hypothalamic neuropeptides discovered in 1998. Since their discovery, they have been one of the most studied neuropeptide systems because of their projecting fields innervating various brain areas. The orexinergic system is tied to sleep-wakefulness cycle, and narcolepsy is a consequence of their system hypofunction. Orexinergic system is also involved in many other autonomic functions such as feeding, thermoregulation, cardiovascular and neuroendocrine regulation. The main aim of this mini review article is to investigate the relationship between ORX and thyroid system regulation. Although knowledge about the ORX system is evolving, its putative effects on hypothalamic-pituitary-thyroid (HPT) axis still appear unclear. We analyzed some studies about ORX control of HPT axis to know better the relationship between them. The studies that were analyzed suggest Hypocretin/ORX to modulate the thyroid regulation, but the nature (excitatory or inhibitory) of this possible interaction remains actually unclear and needs to be confirmed.

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Management of Subclinical Hypothyroidism in Pregnancy: A Comment from the Italian Society of Endocrinology and the Italian Thyroid Association to the 2017 American Thyroid Association Guidelines—“The Italian Way”

Rotondi

Chiovato

Pacini

et al. 2018

Thyroid

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The 2017 American Thyroid Association guidelines for the diagnosis and management of thyroid disease during pregnancy and the postpartum were published six years after the previous ones. They provide comprehensive clinical recommendations for the whole spectrum of thyroid diseases, as well as for optimal iodine intake during pregnancy, postpartum, and lactation. The present position statement mainly regards the recommended flow chart for therapeutic decision making in pregnant women being diagnosed with subclinical hypothyroidism. Here, we comment on the major biochemical and clinical situations and the corresponding therapeutic recommendations. In particular, we welcome the critical revision of the thyrotropin (TSH) reference range in pregnancy, and we agree that there is no need to treat thyroid peroxidase antibody-negative women with a serum TSH ranging from 2.5 μIU/mL to the upper limit of the reference range. This recommendation will hopefully reduce the huge proportion of healthy pregnant women in whom, according to the previous guidelines, levothyroxine therapy had to be initiated. On the other hand, we are concerned with the recommendation to only "consider treatment" in thyroid peroxidase antibody-negative pregnant women with a serum TSH ranging from the upper limit of the reference range to 10.0 μIU/mL. This is because thyroid antibodies may be falsely negative during gestation, and serum negative chronic autoimmune thyroiditis is a well-known clinical entity even outside pregnancy. Based on these and other arguments, we recommend treatment with levothyroxine in pregnant women with TSH levels ranging between the upper limit of the reference range and 10.0 μIU/mL independently from their thyroid antibody status.

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Maternal hypothyroidism and subsequent neuropsychological outcome of the progeny: a family portrait

Cited by 4 publications

References 18 publications

Visual–spatial training efficacy in children affected by migraine without aura: a multicenter study

Visual–spatial training efficacy in children affected by migraine without aura: a multicenter study

Role of the Orexin System on the Hypothalamus-Pituitary-Thyroid Axis

Management of Subclinical Hypothyroidism in Pregnancy: A Comment from the Italian Society of Endocrinology and the Italian Thyroid Association to the 2017 American Thyroid Association Guidelines—“The Italian Way”

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Maternal hypothyroidism and subsequent neuropsychological outcome of the progeny: a family portrait

Cited by 4 publications

References 18 publications

Visual&ndash;spatial training efficacy in children affected by migraine without aura: a multicenter study

Visual&ndash;spatial training efficacy in children affected by migraine without aura: a multicenter study

Role of the Orexin System on the Hypothalamus-Pituitary-Thyroid Axis

Management of Subclinical Hypothyroidism in Pregnancy: A Comment from the Italian Society of Endocrinology and the Italian Thyroid Association to the 2017 American Thyroid Association Guidelines—“The Italian Way”

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Visual–spatial training efficacy in children affected by migraine without aura: a multicenter study

Visual–spatial training efficacy in children affected by migraine without aura: a multicenter study