Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring

Liu, Xiaoqin; Andersen, Stine Linding; Olsen, Jørn; Agerbo, Esben; Schlünssen, Vivi; Dharmage, Shyamali C.; Munk‐Olsen, Trine

doi:10.1111/all.13365

Cited by 30 publications

(30 citation statements)

References 36 publications

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Section: Epidemiology Of Allergic Diseasementioning

confidence: 99%

“…Maternal hypothyroidism is known to increase the risk of childhood asthma in the offspring, especially if the mother did not receive thyroid hormone treatment during pregnancy. 73 The association between bronchial asthma and severe α-1-antitrypsin (AAT) deficiency is unclear. The proportion of individuals with deficient AAT genotypes is similar in asthmatic patients sensitized to HDM to that of the general Spanish population.…”

Section: Epidemi Ology Of Allerg I C D Is E a S Ementioning

confidence: 99%

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Highlights and recent developments in airway diseases in EAACI journals (2018)

Bousquet

Akdiş

Grattan

et al. 2019

Allergy

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The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Pediatric Allergy and Immunology, and Clinical and Translational Allergy. EAACI's major goals include supporting the promotion of health, in which the prevention of allergy and asthma plays a critical role, and disseminating the knowledge of allergic disease to all stakeholders. In 2018, the remarkable progress in the identification of basic mechanisms of allergic and respiratory diseases as well as the translation of these findings into clinical practice were observed. Last year's highlights include publication of EAACI guidelines for allergen immunotherapy, many EAACI Position Papers covering important aspects for the specialty, better understanding of molecular and cellular mechanisms, identification of biomarkers for disease prediction and progress monitoring, novel prevention and intervention studies, elucidation of mechanisms of multimorbidities, introduction of new drugs to the clinics, recently completed phase three clinical studies, and publication of a large number of allergen immunotherapy studies and meta‐analyses.

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Section: Epidemiology Of Allergic Diseasementioning

confidence: 99%

Section: Epidemi Ology Of Allerg I C D Is E a S Ementioning

confidence: 99%

Highlights and recent developments in airway diseases in EAACI journals (2018)

Bousquet

Akdiş

Grattan

et al. 2019

Allergy

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“…1 Reduction and deficiency of iodine are the most preventable cause of hypothyroidism worldwide, and insufficient iodine, autoimmune thyroiditis are major causes of hypothyroidism. 2 In pregnancy, the body's need and demand for thyroid hormone increases. 2 The treatment inadequacy for hypothyroidism has many adverse effects during pregnancy, such as abortion, preterm labor, and complete immobilization of the fetus, as well as autism and decreased IQ in the newborn.…”

Section: Introductionmentioning

confidence: 99%

“…2 In pregnancy, the body's need and demand for thyroid hormone increases. 2 The treatment inadequacy for hypothyroidism has many adverse effects during pregnancy, such as abortion, preterm labor, and complete immobilization of the fetus, as well as autism and decreased IQ in the newborn. 3 Thyroid hormones, through direct and indirect mechanisms, affect intrauterine fetal growth, including direct mechanisms; the effect on embryo metabolism through effects on the consumption of oxygen and glucose by the fetus.…”

Section: Introductionmentioning

confidence: 99%

“…7,8 Therefore, mothers with hypothyroidism, especially when not treated, increase the risk of complications in children. 2 Given that, mothers have a low thyroid dysfunction in the world, and between 2% and 5% of pregnancies, 1 the association between asthma, hyperactivity, mental disorders, seizures in children with low mother's thyroid function is important. According to the studies, hypothyroidism may interfere with the development of vital organs and problems in pulmonary, neurological, mental and evolutionary systems in children.…”

Section: Introductionmentioning

confidence: 99%

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Study of the Consequences of Mothers’ Hypothyroidism in Children: A Systematic Review

Pazokian

Khalandi

2019

Int J Med Rev

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Introduction: Hypothyroidism is a common endocrine disorder that, occurs in 2% to 5% of pregnancies. During pregnancy, the body's demand for thyroid hormones increases, which affects the growth of the fetus. In case of inadequate and defective production of thyroid hormones, adverse effects on the development of the fetus will appear. Lack of symptoms of hypothyroidism during pregnancy causes late diagnosis, resulting in a lack of timely treatment and impaired fetal development. The purpose of this review is to investigate the effects of mothers' hypothyroidism on children. Methods: This systematic review study was performed by searching the Google Scholar, PubMed, and Science Direct databases for the period between 2018 and 2008 by including the keywords for hypothyroidism, thyroid hormones, growth in the uterus. A number of papers related to the use of the Cochran seven-step model were obtained and analyzed for the final analysis. Results: Thyroid hormones play a vital role in fetal development for ectopic life, through direct and indirect mechanisms that, act on the development of the fetus. Thyroid hormones help in the synthesis of surfactant and lung evolution, stimulation of secretion of catecholamine, increased beta-adrenergic receptors of the lung and stimulation: the activity of sodium and potassium pumps in the alveolar cell surface, the effect on the transmission of brain neurotransmitters and growth hormone, and nervous function. Conclusions: Thyroid hormones play a key role in fetal development. Therefore, in women with hypothyroidism, especially when not treated, it affects the development of the fetus and increases the incidence of complications in neonates. So early diagnosis of hypothyroidism and adequate and timely treatment during pregnancy is cornerstone in preventing impaired growth and development of the fetus and the occurrence of defects in childhood.

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Prenatal Origins of Obstructive Airway Disease: Starting on the Wrong Trajectory?

Wang,

James,

Donovan

et al. 2024

Comprehensive Physiology

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From the results of well‐performed population health studies, we now have excellent data demonstrating that deficits in adult lung function may be present early in life, possibly as a result of developmental disorders, incurring a lifelong risk of obstructive airway diseases such as asthma and chronic obstructive pulmonary disease. Suboptimal fetal development results in intrauterine growth restriction and low birth weight at term (an outcome distinct from preterm complications), which are associated with subsequent obstructive disease. Numerous prenatal exposures and disorders compromise fetal development and these are summarized herein. Various physiological, structural, and mechanical abnormalities may result from prenatal disruption, including changes to airway smooth muscle structure–function, goblet cell biology, airway stiffness, geometry of the bronchial tree, lung parenchymal structure and mechanics, respiratory skeletal muscle contraction, and pulmonary inflammation. The literature therefore supports the need for early life intervention to prevent or correct growth defects, which may include simple nutritional or antioxidant therapy. © 2024 American Physiological Society. Compr Physiol 14:5729‐5762, 2024.

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Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring

Abstract: Our findings suggest that maternal hypothyroidism, especially when it is untreated, increases childhood asthma risk. Early detection and appropriate treatment of hypothyroidism in pregnant women may be an area for possible prevention of childhood asthma.

Cited by 30 publications

References 36 publications

Highlights and recent developments in airway diseases in EAACI journals (2018)

Highlights and recent developments in airway diseases in EAACI journals (2018)

Study of the Consequences of Mothers’ Hypothyroidism in Children: A Systematic Review

Prenatal Origins of Obstructive Airway Disease: Starting on the Wrong Trajectory?

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