Maternal immunisation: What have been the gains? Where are the gaps? What does the future hold?

Giles, Michelle; Krishnaswamy, Sushena; Wallace, Euan M.

doi:10.12688/f1000research.15475.1

Cited by 27 publications

(24 citation statements)

References 54 publications

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“…Pregnant women are considered at high risk for severe influenza disease, for this reason, influenza vaccination has been recommended for pregnant women and introduced into immunization programs (84). Influenza vaccination is safe and protective on preterm birth (PTB) and low birth weight (LBW) (85).…”

Section: Neonatal Immunity and Viral Infectionsmentioning

confidence: 99%

Pregnancy, Viral Infection, and COVID-19

et al. 2020

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Pregnancy comprises a unique immunological condition, to allow fetal development and to protect the host from pathogenic infections. Viral infections during pregnancy can disrupt immunological tolerance and may generate deleterious effects on the fetus. Despite these possible links between pregnancy and infection-induced morbidity, it is unclear how pregnancy interferes with maternal response to some viral pathogens. In this context, the novel coronavirus (SARS-CoV-2) can induce the coronavirus diseases-2019 (COVID-19) in pregnant women. The potential risk of vertical transmission is unclear, babies born from COVID-19-positive mothers seems to have no serious clinical symptoms, the possible mechanisms are discussed, which highlights that checking the children's outcome and more research is warranted. In this review, we investigate the reports concerning viral infections and COVID-19 during pregnancy, to establish a correlation and possible implications of COVID-19 during pregnancy and neonatal's health.

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Section: Neonatal Immunity and Viral Infectionsmentioning

confidence: 99%

Pregnancy, Viral Infection, and COVID-19

et al. 2020

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“…Thus, infants appeared to be exposed to pertussis before developing vaccine-induced immunity, being the vaccination coverage at 24 months old extremely high in the study period. It was demonstrated that hospitalizations due to pertussis disproportionately affect children less than three months of age [24].…”

Section: Discussionmentioning

confidence: 99%

Trends in Hospital Admissions for Pertussis Infection: A Nationwide Retrospective Observational Study in Italy, 2002–2016

Fiasca

Gabutti

Mattei

2019

IJERPH

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Background: Pertussis is a highly contagious infectious disease which continues to be an important public-health issue despite the high immunization coverage rates achieved. However, evidence of increased circulation of pertussis among adolescents and adults due to waning immunity and atypical clinical manifestations seem to be the main reasons for its resurgence. The aim of this study was the analysis of the epidemiological trend for pertussis-related hospitalizations in Italy, in relation with vaccination coverage and information from laboratory confirmed cases of pertussis. Methods: A retrospective observational study investigating hospitalizations for pertussis from 2002 to 2016 in Italy was conducted. Frequencies and rates of hospitalization were analyzed and hospitalization data were compared with a series of already published laboratory confirmed data. Results: This study highlighted a rising trend for pertussis hospitalizations in Italy since 2008. Infants aged <1 year showed the highest frequencies (63.39%) and average rates (74.60 × 100000 infants) of hospitalization despite an extremely high vaccination coverage (95.89%). An increasing trend of hospitalization frequency emerged for the age group with levels of IgG antibodies to pertussis toxin compatible with pertussis infection within the last year (20–29 years old age group). Conclusions: The rising trend for pertussis hospitalizations and the greater involvement of infants aged <1 year require an integrated approach, including the implementation of booster doses administration in adolescence and adulthood, the vaccination of pregnant women and the cocoon strategy.

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“…Increasing antenatal care frequency improves the neonatal mortality reduction (11)(12)(13)(14)(15). Similarly, several studies demonstrated that maternal iron and folic acid supplementation (16)(17)(18)(19)(20)(21)(22), tetanus toxoid vaccination of mothers (16,(23)(24)(25)(26) sleeping under insecticide impregnated bed net during pregnancy (10) and syphilis screening (22) significantly reduces neonatal mortalities.…”

Section: Introductionmentioning

confidence: 97%

Intervention fidelity and its determinants of focused antenatal care package implementation, in South Wollo, Northeast Ethiopia.

Tessema

Gebeyehu²,

Mekonnen

et al. 2020

Preprint

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Introduction Evidences show that intervention packages at home-community setting are found to reduce neonatal mortality significantly. But millions of neonates are still dying by preventable causes with the implementation of these effective interventions. This might be due to evidence-practice gap. Therefore, this study aimed at assessing the intervention fidelity and factors influencing focused antenatal care package. Methods Cross-sectional study design was employed in this study. In the selected kebeles’, a total of 898 mothers who gave birth within six months before data collection, ten health posts with their health extension workers were employed. Interview-administered, self-administered and facility audit checklist were used for collecting data from all mothers, health extension workers and health posts respectively. Mothers were asked whether or not the required level of care were provided to them. Health extension workers & health posts were assessed for the competency and organizational drivers. Multilevel linear regression model were used to identify the possible moderating factors at individual and organizational level for intervention fidelity. Result The overall weighted average focused antenatal care package intervention fidelity was 49.78% (95% CI: 47.73 – 51.83). The weighted average focused antenatal care package intervention fidelity by health extension workers was 62.02% (95% CI: 59.71 – 64.32) and skilled providers were 56.57% (95% CI: 53.94 – 59.19). The overall antenatal care coverage were 83.7% (95% CI: 81.28 – 86.12) with 34.97% (95% CI: of 31.56 – 38.39) of mothers received at least four antenatal visit and 6.12% (95% CI: 4.40-7.83) of them received all the recommended components of focused antenatal care. Previous maternal problem, paternal education and implementation of supportive/facilitation strategy were significant facilitators for focused antenatal care package intervention fidelity. Conclusion In this study, focused antenatal care package intervention fidelity was low. This implies that the stagnation of neonatal mortality reduction might be partly due to the low focused antenatal care packages intervention fidelity. Paternal education and implementation of supportive/facilitation strategies were statistically significant facilitators of focused antenatal care intervention package fidelity. Therefore, improvement of implementation of facilitation strategy is recommended.

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Maternal immunisation: What have been the gains? Where are the gaps? What does the future hold?

Cited by 27 publications

References 54 publications

Pregnancy, Viral Infection, and COVID-19

Pregnancy, Viral Infection, and COVID-19

Trends in Hospital Admissions for Pertussis Infection: A Nationwide Retrospective Observational Study in Italy, 2002–2016

Intervention fidelity and its determinants of focused antenatal care package implementation, in South Wollo, Northeast Ethiopia.

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