Maternal influences on litter size and growth in reciprocal crossed Miniature Pigs and Durocs

Hardge, T.; Koepke, K.; Reißmann, Monika; Wimmers, Klaus

doi:10.5194/aab-42-83-1999

Cited by 17 publications

(15 citation statements)

References 20 publications

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“…A three‐generation porcine F2 resource population (DUMI) was examined that is based on reciprocal cross of Duroc and Berlin Miniature Pig (Hardge et al ., 1999). F2 animals ( n = 474, comprising 21 full‐sib families) born from 11 F1 sows mated to three F1 boars with at maximum five parities per sow were reared at the Frankenforst research farm, Institute of Animal Breeding and Genetics, University of Bonn.…”

Section: Methodsmentioning

confidence: 99%

QTL for traits related to humoral immune response estimated from data of a porcine F2 resource population

Wimmers

Muráni

Schellander

et al. 2009

Int J Immunogenetics

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This study aimed to map quantitative trait loci (QTL) for traits related to humoral innate immune defence. Therefore, haemolytic complement activity in the alternative and the classical pathway, serum concentration of C3c and of haptoglobin (HP) were measured in blood samples obtained from F2 piglets (n = 457) of a porcine F2 resource population before and after Mycoplasma hyopneumoniae, Aujeszky's disease virus (Suid herpesvirus I, SuHVI) and porcine reproductive and respiratory syndrome virus (PRRSV) vaccination at 6, 14 and 16 weeks of age. Animals were genotyped at 88 autosomal markers. QTL analysis was performed under the line cross and the half sib. Phenotypic data were adjusted for systematic effects by mixed models with and without repeated measures statement. In total, 46 and 21 estimated QTL positions were detected with genome-wide significance at the 0.05 and 0.01 level, respectively. The proximal region of SSC2 (orthologous to HSA11 0-70 Mb), the distal region of SSC4 (HSA1 95-155 Mb), and the intermediate region of SSC16 (HSA5 0-73 Mb and 150-174 Mb) showed a clustering of estimated QTL positions for complement activity based on the different models. A common genetic background, i.e. a single true QTL, might underlie these QTL positions for related traits. In addition, QTL for antibody titres were detected on SSC1, 2, 6 and 7. With regard to number and magnitude of their impact, QTL for humoral innate immune traits behave like those for other quantitative traits. Discovery of such QTL facilitates the identification of candidate genes for disease resistance and immune competence that are applicable in selective breeding and further research towards improving therapeutic and prophylactic measures.

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Section: Methodsmentioning

confidence: 99%

QTL for traits related to humoral immune response estimated from data of a porcine F2 resource population

Wimmers

Muráni

Schellander

et al. 2009

Int J Immunogenetics

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“…The F2 animals ( n = 457) of the DUMI resource population (Hardge et al , 1999) were genotyped at IL12A and IL12B in order to address linkage and association of the markers with parameters of innate immunity. DUMI resource population F2 animals ( n = 457) born from 11 F1 sows mated to three F1 boars, a maximum five parities per sow, were maintained and phenotyped at the Frankenforst research farm of the Institute of Animal Science, University of Bonn.…”

Section: Methodsmentioning

confidence: 99%

Porcine IL12A and IL12B gene mapping, variation and evidence of association with lytic complement and blood leucocyte proliferation traits

Wimmers

Kumar

Schellander

et al. 2008

Int J Immunogenetics

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Interleukin-12, a heterodimeric cytokine consisting of glycosylated subunits of 35 and 40 kDa, is a central molecule in controlling innate as well as adaptive immunity. This study was aimed to investigate the role of IL12A and IL12B as candidate genes for immune competence in pigs. The porcine genes were screened for polymorphism and association analysis was carried out by mixed model analysis with parameters of innate immunity, in vitro haemolytic complement activity in the classical and alternative pathways, in vivo complement activation expressed as C3c serum concentration, and blood leucocyte proliferation measured in F2 animals of a pig resource population based on cross of Duroc and Berlin miniature pig (DUMI resource population). A single nucleotide polymorphism (SNP) in the promoter region (C > A) of IL12A was identified. Two SNPs were detected in intron 4 of IL12B at positions 192 (A > G) and 437 (C > T). Significant effects of IL12 genotypes on complement activity traits and mitogen-induced leucocyte proliferation were found. The IL12A and IL12B genes were assigned to chromosome13 and 16, respectively, by using radiation hybrid analysis and genetic mapping in the DUMI resource population. Mapping and association analyses promote the IL12 genes as functional and positional candidate gene for disease resistance in pigs.

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“…This growth function is fully described through three parameters, the adult weight ( a ), a parameter that relates the birth weight and the adult weight ( b ), and the rate of maturation ( k ). The Von Bertalanffy function has been widely used to describe growth in pigs (Hardge et al. 1999), cattle (De Behr et al.…”

Section: Introductionmentioning

confidence: 99%

The value of prior information for detection of QTL affecting longitudinal traits: an example using Von Bertalanffy growth function

Varona

Gomez‐Raya

Rauw

et al. 2005

J Animal Breeding Genetics

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A Bayesian procedure is presented for detecting quantitative trait loci (QTL) affecting longitudinal traits. The statistical model assumes a QTL affecting the prior distribution of the parameters of a given production function, under a hierarchical Bayesian scheme. Marginal posterior distributions for the effects associated with the QTL are calculated using Markov chain Monte Carlo methods. Furthermore, the Bayesian analysis allows the use of some available relevant information that can improve the detection of the QTL substantially. To illustrate the procedure, an example of QTL detection using the Von Bertalanffy growth function is presented with a F2 pig population bred from Iberian boars and Landrace sows. Animals of the F2 population were genotyped for seven markers in chromosome 2 (SSC2). Two prior distributions for the mean effect of the parameters related with birth and adult weight were compared. On the one hand, vague prior distributions were used, and, on the other, there were assumed univariate Gaussian distributions that ensure biologically meaningful adult and birth weights on the posterior growth curves. Results from the second prior distribution supported the presence of QTL, by showing that individuals with both alleles of Iberian origin had lower rates of maturation. On the contrary, when vague priors were used, the procedure was not able to detect QTL.

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Maternal influences on litter size and growth in reciprocal crossed Miniature Pigs and Durocs

Cited by 17 publications

References 20 publications

QTL for traits related to humoral immune response estimated from data of a porcine F2 resource population

QTL for traits related to humoral immune response estimated from data of a porcine F2 resource population

Porcine IL12A and IL12B gene mapping, variation and evidence of association with lytic complement and blood leucocyte proliferation traits

The value of prior information for detection of QTL affecting longitudinal traits: an example using Von Bertalanffy growth function

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