1986
DOI: 10.1016/0002-9378(86)90823-9
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Maternal ingestion of acetylsalicylic acid inhibits fetal and neonatal prostacyclin and thromboxane in humans

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Cited by 52 publications
(14 citation statements)
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“…In the present study, we further examined if apical exposure of aspirin could attenuate AA-induced apical/basal releases of TX by normal and/or preeclamptic trophoblasts. The concentrations of aspirin used in this study (10μM and 100μM) were relatively compatible to the concentrations of aspirin measured in the umbilical circulation after maternal ingestion of aspirin of 100 mg or 500 mg (23,24) and similar to the previously published in vitro works (22,23). Our results showed that neither apical nor basal release of PGI2 was affected in cultured trophoblasts with apical exposure of aspirin, although previous reports showed that the same concentration of aspirin 100μM exhibited an inhibitory effect on PGI2 production (22,23).…”
Section: Discussionsupporting
confidence: 73%
“…In the present study, we further examined if apical exposure of aspirin could attenuate AA-induced apical/basal releases of TX by normal and/or preeclamptic trophoblasts. The concentrations of aspirin used in this study (10μM and 100μM) were relatively compatible to the concentrations of aspirin measured in the umbilical circulation after maternal ingestion of aspirin of 100 mg or 500 mg (23,24) and similar to the previously published in vitro works (22,23). Our results showed that neither apical nor basal release of PGI2 was affected in cultured trophoblasts with apical exposure of aspirin, although previous reports showed that the same concentration of aspirin 100μM exhibited an inhibitory effect on PGI2 production (22,23).…”
Section: Discussionsupporting
confidence: 73%
“…The side effect most commonly considered in association with ASA treatment during pregnancy is excess bleeding. A 100 mg single dose of ASA did not affect umbilical artery PGI 2 production, whereas 500 mg significantly inhibited production as well as tending to suppress urinary excretion of 6‐keto by newborns (Yli‐korkala et al 1986). In the present study, long term treatment with 50 mg of ASA daily prolonged bleeding time in mothers, but it was clinically insignificant since no bleeding‐related complications, such as placental abruption, appeared and bleeding during delivery was normal.…”
Section: Discussionmentioning
confidence: 95%
“…The ratio between prostacyclin and thromboxane (a powerful vasoconstrictor and inducer of platelet aggregation) is thought to be important in the regulation of platelet and vascular function. Low‐dose aspirin (100 mg) has minimal effect on prostacyclin production, but is a potent inhibitor of thromboxane 6 . It therefore alters the ratio of prostanoids in favour of improved perfusion and could enhance fetal growth.…”
Section: Introductionmentioning
confidence: 99%