Maternal inheritance of human mitochondrial DNA.

Abstract

ABSTRAUIr Human mitochondrial DNA was obtained from peripheral blood platelets donated by the members of several independent families. The samples were screened for nucleotide sequence polymorphisms between individuals within these families. In each family in which we were able to detect a distinctly different restriction endonuclease cleavage pattern between the parents, the progeny exhibited the maternal cleavage pattern. Informative

Is paternal mitochondrial DNA transferred to the offspring following intracytoplasmic sperm injection?

“…It has been demonstrated convincingly that the mitochondrial genome is inherited exclusively from the mother (8)(9)(10). Recently paternal transmission of the mtDNA has been shown to occur in interspecific crossings (11), but accumulated data indicate that intraspecific mtDNA derived from sperm or other sources is efficiently eliminated at an.early stage of embryonic development after normal in vivo fertilization and in different experimental situations including, e.g., injection of testes and liver mitochondria into zygotes of mice.…”

Molecular genetic basis of primary inherited optic neuropathies

“…As mitochondria are maternally inherited 5 there is no male to male transmission in an LHON pedigree. Human mitochondrial DNA (mtDNA) is a closed, circular molecule of 16569 base pairs.…”

Mitochondrial DNA variability in natural populations of Hawaiian Drosophila. I. Methods and levels of variability in D. silvestris and D. heteroneura populations

“…Genetic distance between this line and D. heteroneura mtDNA restriction endonuclease data has recently been applied to the population genetics of humans and apes (Brown, 1980;Cann et a!., 1982;Ferris et al, 1981), lizards (Brown and Wright, 1979), rodents (Lansman et a!., 1981;Brown and Simpson, 1981;Ferris et al, 1983;Avise et al, 1983) and Drosophila (Shah and Langley, 1979;Powell, 1983;Powell and Zuniga, 1983). Vertebrate mtDNA is relatively easy to analyse as it is available in relatively large amounts per individual (Giles et aL, 1980;Lansman et a!., 1981;Ferris et al, 1983). As Powell (1983) points out, however, mtDNA restriction techniques in Drosophila systems usually demands that isofemale lines are used to obtain enough tissue to isolate mtDNA.…”