Maternal iron nutriture modulates placental development in a rat model of fetal alcohol spectrum disorder

Kwan, Sze Ting Cecilia; Kezer, Camille A.; Helfrich, Kaylee K.; Saini, Nipun; Huebner, Shane M.; Flentke, George R.; Kling, Pamela J.; Smith, Susan

doi:10.1016/j.alcohol.2019.11.003

Cited by 14 publications

(17 citation statements)

References 68 publications

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“…Gestational alcohol exposure impaires the respiratory gases supply due to poor placental vascularity, leading to hypoxia, thus resulting in pregnancy complications, IUGR, and preeclampsia, malnutrition, or stillbirth (Aliyu et al, 2008(Aliyu et al, , 2011Salihu et al, 2011;Carter et al, 2016). Ethanol interferes with placental transport of nutrients, oxygen, and waste products (Gundogan et al, 2008(Gundogan et al, , 2015Kwan et al, 2020). Moreover, prenatal alcohol exposure alters the placental iron transport yielding to fetal iron deficiency anemia, condition that exacerbates alcohol-related growth restriction (Kwan et al, 2020).…”

Section: Main Effects Of Gestational Alcohol Consumption On Placentamentioning

confidence: 99%

“…Ethanol interferes with placental transport of nutrients, oxygen, and waste products (Gundogan et al, 2008(Gundogan et al, , 2015Kwan et al, 2020). Moreover, prenatal alcohol exposure alters the placental iron transport yielding to fetal iron deficiency anemia, condition that exacerbates alcohol-related growth restriction (Kwan et al, 2020). Also, animal and in vitro studies have suggested that chronic and heavy alcohol use in pregnancy may impair transport of folic acid across the placenta to the fetus by decreasing expression of transport proteins, thus contributing to the deficits observed in FASD (Hutson et al, 2012).…”

Section: Main Effects Of Gestational Alcohol Consumption On Placentamentioning

confidence: 99%

“…Moreover, high risk of placental abruption was observed after consumption of 7-21 drinks per week (a mean of two drinks per day and BAC of 5-100 mg/dL) (Burd et al, 2007). In human and animal models, alcohol exposure during pregnancy usually reduces placental weight and size, affecting directly the structure and function (Gundogan et al, 2008(Gundogan et al, , 2015Bosco and Diaz, 2012;Carter et al, 2016;Kwan et al, 2020). The most generalized effects of gestational alcohol intake on the placenta were on its vasculature, which is associated with uteroplacental malperfusion, resistance, and placental and umbilical cord contraction (Iveli et al, 2007).…”

Section: Main Effects Of Gestational Alcohol Consumption On Placentamentioning

confidence: 99%

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Early Abnormal Placentation and Evidence of Vascular Endothelial Growth Factor System Dysregulation at the Feto-Maternal Interface After Periconceptional Alcohol Consumption

et al. 2022

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Adequate placentation, placental tissue remodeling and vascularization is essential for the success of gestation and optimal fetal growth. Recently, it was suggested that abnormal placenta induced by maternal alcohol consumption may participate in fetal growth restriction and relevant clinical manifestations of the Fetal Alcohol Spectrum Disorders (FASD). Particularly, periconceptional alcohol consumption up to early gestation can alter placentation and angiogenesis that persists in pregnancy beyond the exposure period. Experimental evidence suggests that abnormal placenta following maternal alcohol intake is associated with insufficient vascularization and defective trophoblast development, growth and function in early gestation. Accumulated data indicate that impaired vascular endothelial growth factor (VEGF) system, including their downstream effectors, the nitric oxide (NO) and metalloproteinases (MMPs), is a pivotal spatio-temporal altered mechanism underlying the early placental vascular alterations induced by maternal alcohol consumption. In this review we propose that the periconceptional alcohol intake up to early organogenesis (first trimester) alters the VEGF-NO-MMPs system in trophoblastic-decidual tissues, generating imbalances in the trophoblastic proliferation/apoptosis, insufficient trophoblastic development, differentiation and migration, deficient labyrinthine vascularization, and uncompleted remodelation and transformation of decidual spiral arterioles. Consequently, abnormal placenta with insufficiency blood perfusion, vasoconstriction and reduced labyrinthine blood exchange can be generated. Herein, we review emerging knowledge of abnormal placenta linked to pregnancy complications and FASD produced by gestational alcohol ingestion and provide evidence of the early abnormal placental angiogenesis-vascularization and growth associated to decidual-trophoblastic dysregulation of VEGF system after periconceptional alcohol consumption up to mid-gestation, in a mouse model.

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Section: Main Effects Of Gestational Alcohol Consumption On Placentamentioning

confidence: 99%

Section: Main Effects Of Gestational Alcohol Consumption On Placentamentioning

confidence: 99%

Section: Main Effects Of Gestational Alcohol Consumption On Placentamentioning

confidence: 99%

See 1 more Smart Citation

Early Abnormal Placentation and Evidence of Vascular Endothelial Growth Factor System Dysregulation at the Feto-Maternal Interface After Periconceptional Alcohol Consumption

et al. 2022

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“…Rats with PAE present with significantly reduced fetal total, brain, liver, and placental weight compared with those without PAE [ 61 , 62 , 63 , 65 ]. In one study, rats with ID-PAE had reduced body and liver weights compared to those fetuses with IS-PAE [ 61 ].…”

Section: Literature Synthesismentioning

confidence: 99%

“…In another study, in both male and female offspring, maternal ID reduced postnatal growth; in male offspring, PAE interacted with maternal ID to further restrict growth [ 32 ]. PAE significantly reduced placental weight and placental efficiency; the lowest placental efficiency was found in ID-PAE dams [ 63 ]. The placenta efficiency was higher (but not statistically significant) in the iron-fortified PAE dams [ 63 ].…”

Section: Literature Synthesismentioning

confidence: 99%

Fetal Alcohol Spectrum Disorder and Iron Homeostasis

et al. 2022

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Prenatal alcohol exposure results in a spectrum of behavioral, cognitive, and morphological abnormalities collectively referred to as fetal alcohol spectrum disorder (FASD). FASD presents with significant phenotypic variability and may be modified by gestational variables such as maternal nutritional status. Iron serves a critical function in the development of and processes within central nervous system (CNS) structures. Gestational iron deficiency alters CNS development and may contribute to neurodevelopmental impairment in FASD. This review explores the relationship between iron deficiency and fetal alcohol spectrum disorder as described in small animal and human studies. Consideration is given to the pathophysiologic mechanisms linking iron homeostasis and prenatal alcohol exposure. Existing data suggest that iron deficiency contributes to the severity of FASD and provide a mechanistic explanation linking these two conditions.

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Iron deficiency, pregnancy, and neonatal development

Ataíde

Fielding

Pasricha

et al. 2023

Intl J Gynecology & Obste

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Anemia affects 36% of pregnant women worldwide. Of those affected, around 40% is due to iron deficiency (ID). Iron is an essential micronutrient involved in vital processes such as erythropoiesis, immune responses, and importantly—during pregnancy—placental and fetal development. Although menstrual bleeding can impact the incidence of ID even before the onset of pregnancy, this narrative review is pregnancy focused and will explore the impact of ID on placental development and iron uptake, fetal development and immunity, and maternal and infant susceptibility to infection. Although there have been advances in this area of research, much is needed to understand the regulation of iron and the effects of ID during pregnancy. Notably, more human studies are essential to generate the best evidence to advance strategies to reduce the incidence of ID during pregnancy to improve maternal, neonatal, and infant health.

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Maternal iron nutriture modulates placental development in a rat model of fetal alcohol spectrum disorder

Cited by 14 publications

References 68 publications

Early Abnormal Placentation and Evidence of Vascular Endothelial Growth Factor System Dysregulation at the Feto-Maternal Interface After Periconceptional Alcohol Consumption

Early Abnormal Placentation and Evidence of Vascular Endothelial Growth Factor System Dysregulation at the Feto-Maternal Interface After Periconceptional Alcohol Consumption

Fetal Alcohol Spectrum Disorder and Iron Homeostasis

Iron deficiency, pregnancy, and neonatal development

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