Maternal isolation alters the expression of neural proteins during development: ‘Stroking’ stimulation reverses these effects

Chatterjee, Diptendu; Chatterjee-Chakraborty, Munmun; Rees, Stephanie; Cauchi, Jonathan; Medeiros, Cynthia B. de; Fleming, Alison S.

doi:10.1016/j.brainres.2007.04.069

Cited by 84 publications

(77 citation statements)

References 82 publications

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“…54 Tactile stimulation also compensates for inadequate maternal care: the negative effects produced by repeated episodes of maternal separation or by prenatal stress on pup growth, hormone secretion, hypothalamus-pituitary-adrenal axis and BDNF expression are all rescued by artificial massage applied to pups in order to mimic maternal behaviour. [55][56][57] Altogether, these results provide a remarkable example of cross-modal plasticity by which an increased input in a single modality reverberates as a driving force for the whole brain.…”

Section: Maternal Care Tactile Stimulation and Visual System Developmentioning

confidence: 71%

Nurturing brain plasticity: impact of environmental enrichment

et al. 2009

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Environmental enrichment (EE) is known to profoundly affect the central nervous system (CNS) at the functional, anatomical and molecular level, both during the critical period and during adulthood. Recent studies focusing on the visual system have shown that these effects are associated with the recruitment of previously unsuspected neural plasticity processes. At early stages of brain development, EE triggers a marked acceleration in the maturation of the visual system, with maternal behaviour acting as a fundamental mediator of the enriched experience in both the foetus and the newborn. In adult brain, EE enhances plasticity in the cerebral cortex, allowing the recovery of visual functions in amblyopic animals. The molecular substrate of the effects of EE on brain plasticity is multi-factorial, with reduced intracerebral inhibition, enhanced neurotrophin expression and epigenetic changes at the level of chromatin structure. These findings shed new light on the potential of EE as a non-invasive strategy to ameliorate deficits in the development of the CNS and to treat neurological disorders.

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Section: Maternal Care Tactile Stimulation and Visual System Developmentioning

confidence: 71%

Nurturing brain plasticity: impact of environmental enrichment

et al. 2009

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“…Pups reared under these conditions exhibit impaired social learning (Levy et al, 2003), reduced attention (Lovic and Fleming, 2004), and increased impulsivity (Lovic et al, 2011). Within the brain, maternally deprived pups have reductions in neurotrophic factors, which may result in impaired neural development and reduced plasticity (Chatterjee et al, 2007). Reduction in neurotropic factors in the prefrontal cortex is also observed in pups that have experienced abusive caregiving in infancy (Roth et al, 2009).…”

Section: Developmental Impact Of Maternal Behavior In Laboratory Rodentsmentioning

confidence: 91%

Early-Life Experience, Epigenetics, and the Developing Brain

Kundaković

Champagne

2014

Neuropsychopharmacol

257

182

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Development is a dynamic process that involves interplay between genes and the environment. In mammals, the quality of the postnatal environment is shaped by parent-offspring interactions that promote growth and survival and can lead to divergent developmental trajectories with implications for later-life neurobiological and behavioral characteristics. Emerging evidence suggests that epigenetic factors (ie, DNA methylation, posttranslational histone modifications, and small noncoding RNAs) may have a critical role in these parental care effects. Although this evidence is drawn primarily from rodent studies, there is increasing support for these effects in humans. Through these molecular mechanisms, variation in risk of psychopathology may emerge, particularly as a consequence of early-life neglect and abuse. Here we will highlight evidence of dynamic epigenetic changes in the developing brain in response to variation in the quality of postnatal parent-offspring interactions. The recruitment of epigenetic pathways for the biological embedding of early-life experience may also have transgenerational consequences and we will describe and contrast two routes through which this transmission can occur: experience dependent vs germline inheritance. Finally, we will speculate regarding the future directions of epigenetic research and how it can help us gain a better understanding of the developmental origins of psychiatric dysfunction.

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“…The offsprings of mother rats with high or low licking and grooming behavior show, once adult, differences in novelty reaction, in exploratory behavior, in spatial learning and memory, in the level of glucocorticoids receptors in the hippocampus, leading to a difference in the feedback control on hypothalamus-pituitary-adrenal axis, and in spine density and synaptic plasticity in the hippocampus (Liu et al, 2000;Weaver et al, 2004Weaver et al, , 2006Weaver et al, , 2007Meaney and Szyf, 2005;Champagne and Curley, 2009). Studies in rodents devoted to the exploration of a specific role of tactile stimulation have shown that the negative effects produced by maternal separation/deprivation or prenatal stress on pup growth, growth hormone (GH) secretion, HPA axis, and BDNF and synaptophysin expression, were rescued by tactile stimulation of the pups (Schanberg and Field, 1987;Burton et al, 2007;Chatterjee et al, 2007). Working in preterm infants, Schanberg and Field (1987) found evidence that massage promoted a faster weight gain and a lower level of cortisol in massaged infants.…”

Section: Introductionmentioning

confidence: 99%

Massage Accelerates Brain Development and the Maturation of Visual Function

Guzzetta¹,

Baldini²,

Bancale³

et al. 2009

J. Neurosci.

209

162

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Environmental enrichment (EE) was shown recently to accelerate brain development in rodents. Increased levels of maternal care, and particularly tactile stimulation through licking and grooming, may represent a key component in the early phases of EE. We hypothesized that enriching the environment in terms of body massage may thus accelerate brain development in infants. We explored the effects of body massage in preterm infants and found that massage accelerates the maturation of electroencephalographic activity and of visual function, in particular visual acuity. In massaged infants, we found higher levels of blood IGF-1. Massage accelerated the maturation of visual function also in rat pups and increased the level of IGF-1 in the cortex. Antagonizing IGF-1 action by means of systemic injections of the IGF-1 antagonist JB1 blocked the effects of massage in rat pups. These results demonstrate that massage has an influence on brain development and in particular on visual development and suggest that its effects are mediated by specific endogenous factors such as IGF-1.

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Maternal isolation alters the expression of neural proteins during development: ‘Stroking’ stimulation reverses these effects

Cited by 84 publications

References 82 publications

Nurturing brain plasticity: impact of environmental enrichment

Nurturing brain plasticity: impact of environmental enrichment

Early-Life Experience, Epigenetics, and the Developing Brain

Massage Accelerates Brain Development and the Maturation of Visual Function

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