Maternal L‐carnitine supplementation promotes brown adipose tissue thermogenesis of newborn goats after cold exposure

Liu, Xin; Fan, Wenli; Zhang, Xujia; Zhan, Siyuan; Zhong, Tao; Guo, Jiazhong; Wang, Yan; Cao, Jiaxue; Li, Li; Zhang, Hongping; Wang, Linjie

doi:10.1096/fj.202200637r

Cited by 11 publications

(4 citation statements)

References 63 publications

(115 reference statements)

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“…l -carnitine promotes the β oxidation of long-chain fatty acids across mitochondrial membranes, which in turn promotes energy metabolism 70 . Dietary supplementation with l -carnitine has been shown to increase the growth rate of weaned calves and feed conversion in lambs 71 , 72 , and maternal l -carnitine supplementation has been shown to promote the development and thermogenesis of white adipose tissue in neonatal goats 73 . l -carnitine supplementation has been shown to increase plasma IGF-1 levels 74 , 75 and play an important role in muscle cell proliferation 76 and increase birth weight 77 .…”

Section: Discussionmentioning

confidence: 99%

Comparative metabolomics reveals serum metabolites changes in goats during different developmental stages

Li,

Chao,

Wang

et al. 2024

Sci Rep

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Goats can provide meat, milk and skins for humans and are livestock with high economic benefits. However, despite their economic significance, the comprehensive analysis of goats’ serum metabolic profile and its intricate alterations throughout their developmental journey remains conspicuously absent. To investigate the stage-specificity and dynamic change characteristics of metabolites during the growth and development of goats, this study compared the alterations in serum hormone levels and serum biochemical markers across different developmental stages of female goats (1, 60, 120 and 180 days old; n = 5). Additionally, a serum untargeted LC–MS metabolomics analysis was conducted. A total of 504 DAMs were identified with age. The results indicated that PE, PC, Lyso-PE, Lyso-PC and FAFHA may play important roles in lipid metabolism in goats after birth. Weighted gene co-expression network analysis (WGCNA) identified two metabolite modules (Turquoise and Yellow) and key metabolites within these modules that were significantly associated with phenotypic features. l-carnitine may be a metabolite related to muscle development in goats. The findings of this study demonstrate notable variations in serum metabolites across distinct developmental phases in goats. Lipids and organic acids play important roles in different developmental stages of goats.

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Section: Discussionmentioning

confidence: 99%

Comparative metabolomics reveals serum metabolites changes in goats during different developmental stages

Li,

Chao,

Wang

et al. 2024

Sci Rep

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“…Moreover, maternal L-carnitine supplementation increased the rectal temperature of newborn goats and promoted BAT thermogenesis. Further research found that L-carnitine promoted TG and glycogen deposition in brown adipocytes through AMPKα [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

A Novel LncRNA MSTRG.310246.1 Promotes Differentiation and Thermogenesis in Goat Brown Adipocytes

Tang

Liu

et al. 2023

Genes

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Brown adipose tissue (BAT) plays a critical role in maintaining the body temperature in newborn lamb due to its unique non-shivering thermogenesis. Previous studies have found that BAT thermogenesis is regulated by several long non-coding RNAs (lncRNAs). Here, we identified a novel lncRNA, MSTRG.310246.1, which was enriched in BAT. MSTRG.310246.1 was localized in both the nuclear and cytoplasmic compartments. In addition, MSTRG.310246.1 expression was upregulated during brown adipocyte differentiation. Overexpression of MSTRG.310246.1 increased the differentiation and thermogenesis of goat brown adipocytes. On the contrary, the knockdown of MSTRG.310246.1 inhibited the differentiation and thermogenesis of goat brown adipocytes. However, MSTRG.310246.1 had no effect on goat white adipocyte differentiation and thermogenesis. Our results show that MSTRG.310246.1 is a BAT-enriched LncRNA that improves the differentiation and thermogenesis of goat brown adipocytes.

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“…However, these effects were found to be recoverable with l -carnitine supplementation [ 80 ]. Another finding observed in newborn goats indicates that maternal l -carnitine supplementation enhances BAT development and thermogenesis [ 81 ]. This underscores the significance of maternal nutrition in the development of mammalian infants.…”

Section: Nutritional Factors Regulate Bat Activitymentioning

confidence: 99%

Brown Fat and Nutrition: Implications for Nutritional Interventions

Noriega,

Yang,

Wang

2023

Nutrients

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Brown and beige adipocytes are renowned for their unique ability to generate heat through a mechanism known as thermogenesis. This process can be induced by exposure to cold, hormonal signals, drugs, and dietary factors. The activation of these thermogenic adipocytes holds promise for improving glucose metabolism, reducing fat accumulation, and enhancing insulin sensitivity. However, the translation of preclinical findings into effective clinical therapies poses challenges, warranting further research to identify the molecular mechanisms underlying the differentiation and function of brown and beige adipocytes. Consequently, research has focused on the development of drugs, such as mirabegron, ephedrine, and thyroid hormone, that mimic the effects of cold exposure to activate brown fat activity. Additionally, nutritional interventions have been explored as an alternative approach to minimize potential side effects. Brown fat and beige fat have emerged as promising targets for addressing nutritional imbalances, with the potential to develop strategies for mitigating the impact of metabolic diseases. Understanding the influence of nutritional factors on brown fat activity can facilitate the development of strategies to promote its activation and mitigate metabolic disorders.

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Maternal L‐carnitine supplementation promotes brown adipose tissue thermogenesis of newborn goats after cold exposure

Cited by 11 publications

References 63 publications

Comparative metabolomics reveals serum metabolites changes in goats during different developmental stages

Comparative metabolomics reveals serum metabolites changes in goats during different developmental stages

A Novel LncRNA MSTRG.310246.1 Promotes Differentiation and Thermogenesis in Goat Brown Adipocytes

Brown Fat and Nutrition: Implications for Nutritional Interventions

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