Maternal lifestyle characteristics and Wilms tumor risk in the offspring: A systematic review and meta-analysis

Doganis, Dimitrios; Katsimpris, Andreas; Panagopoulou, Paraskevi; Bouka, Panagiota; Bouka, Evdoxia; Moschovi, Maria; Polychronopoulou, Sofia; Παπακωνσταντίνου, Ευγενία; Tragiannidis, Athanasios; Katzilakis, Nick; Dana, Helen; Antoniadi, Kondilia; Stefanaki, Kalliopi; Strantzia, Katerina; Dessypris, Nick; Schüz, Joachim; Petridou, Eleni

doi:10.1016/j.canep.2020.101769

Cited by 5 publications

(6 citation statements)

References 73 publications

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“…Only approximately 300 cases of nephroblastoma (WT) in adults have been documented in the literature with varying terminologies and confusing histological diagnosis 5 . Nephroblastoma presents as a triphasic embryonal tumor with various proportions of blastema, stroma, and epithelial cells 8 . Blastemal cells are the most malignant tumor component as they are the least differentiated with rapid mitotic activity.…”

Section: Discussionmentioning

confidence: 99%

Disseminated adult Wilms tumor in pregnancy: Leveraging multidisciplinary care in a low‐resource setting

Sepenu,

Swarray‐Deen,

Scott

et al. 2023

Intl J Gynecology & Obste

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Wilms tumor (WT) occurring in adults is rare and even much more rarely found to coexist with pregnancy. Clinical outcome in adults is worse overall compared with pediatric patients with WT and is often misdiagnosed with no standardized protocols for care guided by high‐evidence clinical trials. We present a case of a 23‐year‐old woman diagnosed with WT who was found to be pregnant immediately following nephrectomy. Workup findings showed that she had disseminated disease but was successfully managed in a multidisciplinary team setting with modified intrapartum chemotherapy followed by postpartum chemotherapy. In low‐resource settings, management protocols for adult patients with WT can be individualized by multidisciplinary teams to leverage available resources for best outcomes.

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Section: Discussionmentioning

confidence: 99%

Disseminated adult Wilms tumor in pregnancy: Leveraging multidisciplinary care in a low‐resource setting

Sepenu,

Swarray‐Deen,

Scott

et al. 2023

Intl J Gynecology & Obste

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“…It is well known that parents' exposure to external factors such as stress, education, social status, place of residence, noxious substances, diet, and environmental influences also has a consecutive effect on unborn children. This has been discussed in several studies considering such influences of environmental exposures [14] like pesticides [15], hydrocarbon solvents and engine exhausted fumes [16], intake of vitamins and folic acid as well as drinking or smoking during pregnancy [17], maternal use of household pesticides and insecticides [18], hazardous chemicals [19], paternal lead (Pb) exposure [20], and paternal occupation exposures [21].…”

Section: Discussionmentioning

confidence: 99%

An Observational Case-Control Study on Parental Age and Childhood Renal Tumors

Politis,

Wagenpfeil,

Welter

et al. 2023

Cancers

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Despite excellent outcomes, many open questions remain about Wilms tumor (WT). Influences and risk factors for tumorigenesis, as well as tumor aggressiveness and recurrence, are not fully understood. Parental age plays a role in various childhood diseases and is also discussed as a risk factor for childhood cancer. We analyzed both maternal and paternal age at birth as risk factors for the occurrence of Wilms and non-Wilms tumors in children and investigated whether older maternal or paternal age is associated with a higher tumor incidence. During 1990 and 2019 we collected data from 3991 patients from the multicenter studies SIOP9/GPO, SIOP 93-01/GPOH, and SIOP 2001/GPOH, of whom maternal and paternal age was available in 2277 cases. Data from the Federal Statistical Office containing live births in Germany from 1990–2019 served as a comparative database. For maternal age at birth, the control data yielded 22,451,412 cases and for paternal age yielded 19,046,314 cases. Comparing maternal and paternal ages of the study patients with those of the control data, we confirmed that higher parental age is not correlated with the incidence of renal tumors in childhood. Mean ages of fathers and mothers in patients and the control cohort increased between 1991 and 2019 (fathers: 30.28 vs. 34.04; mothers: 27.68 vs. 29.79 in the patient group and 31.29 vs. 34.23 and 28.88 vs. 32.67 in the control group, respectively) without higher numbers of patients with kidney cancer over time. No influence was found for the subtype of cancer nor for syndromes. In addition, overall survival of patients is independent of the year of diagnosis and the age of the parents but depends on histology type and stage in WT.

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“…Case-control: 117 cases Doganis, D., 2020 [117] Maternal lifestyle characteristics Wilms tumor Greece Positive association 5.31, 2.00-14.10 was found for mothers who consumed alcohol only before pregnancy and Wilms tumor.…”

Section: Brain Tumors Australiamentioning

confidence: 99%

Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade

Navarrete-Meneses,

Salas-Labadía,

Gómez-Chávez

et al. 2024

IJMS

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The long-term effects of environmental pollution have been of concern as several pollutants are carcinogenic, potentially inducing a variety of cancers, including childhood cancer, which is a leading cause of death around the world and, thus, is a public health issue. The present scoping review aimed to update and summarize the available literature to detect specific environmental pollutants and their association with certain types of childhood cancer. Studies published from 2013 to 2023 regarding environmental pollution and childhood cancer were retrieved from the PubMed database. A total of 174 studies were eligible for this review and were analyzed. Our search strategy brought up most of the articles that evaluated air pollution (29%) and pesticides (28%). Indoor exposure to chemicals (11%), alcohol and tobacco use during pregnancy (16%), electromagnetic fields (12%), and radon (4%) were the subjects of less research. We found a particularly high percentage of positive associations between prenatal and postnatal exposure to indoor (84%) and outdoor (79%) air pollution, as well as to pesticides (82%), and childhood cancer. Positive associations were found between leukemia and pesticides and air pollution (33% and 27%); CNS tumors and neuroblastoma and pesticides (53% and 43%); and Wilms tumor and other rare cancers were found in association with air pollution (50%). Indoor air pollution was mostly reported in studies assessing several types of cancer (26%). Further studies are needed to investigate the mechanisms underlying the potential associations between indoor/outdoor air pollution and pesticide exposure with childhood cancer risk as more preventable measures could be taken.

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Maternal lifestyle characteristics and Wilms tumor risk in the offspring: A systematic review and meta-analysis

Cited by 5 publications

References 73 publications

Disseminated adult Wilms tumor in pregnancy: Leveraging multidisciplinary care in a low‐resource setting

Disseminated adult Wilms tumor in pregnancy: Leveraging multidisciplinary care in a low‐resource setting

An Observational Case-Control Study on Parental Age and Childhood Renal Tumors

Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade

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