Maternal Long-Term Intake of Inulin Improves Fetal Development through Gut Microbiota and Related Metabolites in a Rat Model

Xie, Peng; Huang, Yingyan; Wang, Guixiang; He, Ying; Hu, Liang; Fang, Zhengfeng; Xu, Shengyu; Li, Jian; Tang, Jieyuan; Hua, Lun; Jiang, Xuemei; Wu, De

doi:10.1021/acs.jafc.1c07284

Cited by 3 publications

(5 citation statements)

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“…Holanda et al found that nursery pigs with light weaning body weight were more susceptible to jejunal inflammation and had impaired intestinal health due to weaning stress [29]. In addition to antioxidant effects, the supplementation of inulin and VD can improve the development of animals' mammary glands and the composition of milk, which can provide better nutrition for lactating offspring [22,30]. Insufficient vitamin D intake during pregnancy has been found to reduce fetal birth weight [31].…”

Section: Discussionmentioning

confidence: 99%

“…Dietary supplementation of inulin can improve hyperlipidemia and hyperglycemia, and regulate intestinal flora in animals [21]. In recent years, studies on dietary inulin addition in animals during the gestation and lactation periods have shown that maternal inulin addition can decrease oxidative stress level, improve the development of mammary glands and milk ingredients in mothers, and affect the composition of milk to provide better nutrition for lactating offspring [22]. In addition, maternal dietary inulin supplementation can increase a neonate's tolerance to food antigens and sensitinogens, which supports earlier neonatal adaptation to the environment and diet [22,23].…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, studies on dietary inulin addition in animals during the gestation and lactation periods have shown that maternal inulin addition can decrease oxidative stress level, improve the development of mammary glands and milk ingredients in mothers, and affect the composition of milk to provide better nutrition for lactating offspring [22]. In addition, maternal dietary inulin supplementation can increase a neonate's tolerance to food antigens and sensitinogens, which supports earlier neonatal adaptation to the environment and diet [22,23]. However, the effect of maternal inulin supplementation during pregnancy and lactation on the oxidative status of offspring needs to be further explored.…”

Section: Introductionmentioning

confidence: 99%

“…Dietary supplementation of fructooligosaccharides, such as inulin, is beneficial to the absorption of VD, calcium and phosphorus, which further promotes the bone growth and development of adolescents [24]. In addition, dietary VD or inulin supplementation in gestation has been proven to enhance the gestation outcome [13,14,22,25]. However, the effect of combinatorial VD and inulin supplementation during pregnancy and lactation on the health of offspring is unclear.…”

Section: Introductionmentioning

confidence: 99%

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Maternal Vitamin D and Inulin Supplementation in Oxidized Oil Diet Improves Growth Performance and Hepatic Innate Immunity in Offspring Mice

et al. 2023

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Dietary oxidized fat contains harmful materials such as hydrogen peroxide and malondialdehyde (MDA). Excessive oxidized fat intake during pregnancy and lactation not only leads to maternal body injury but also damages offspring health. Our previous study demonstrated that vitamin D (VD) had antioxidative capability in sows. This study was conducted to investigate the effect of maternal VD and inulin supplementation in oxidized oil diet on the growth performance and oxidative stress of their offspring. Sixty 5-month-old C57BL/6N female mice were randomly divided into five groups: Control group (basal diet, n = 12), OF group (oxidized-soybean-oil-replaced diet, n = 12), OFV group (oxidized-soybean-oil-replaced diet + 7000 IU/kg VD, n = 12), OFI group (oxidized-soybean-oil-replaced diet + 5% inulin, n = 12) and OFVI group (oxidized-soybean-oil-replaced diet + 7000 IU/kg VD + 5% inulin, n = 12). Mice were fed with the respective diet during pregnancy and lactation. The offspring were then slaughtered on day 21 of age at weaning. Results showed that a maternal oxidized oil diet impaired body weight and liver weight gain of offspring during lactation compared to the control group, while maternal VD, inulin or VD and inulin mixture supplementation reversed this effect. In addition, the activity of T-AOC in the liver of offspring was lower in the OF group than that in the control group, but could be restored by maternal VD and inulin mixture supplementation. Furthermore, the gene expression of both proinflammatory and anti-inflammatory cytokines, such as Il-6, Tnfα and Il-10, in offspring liver were downregulated by a maternal oxidized oil diet compared with the control group, but they were restored by maternal VD or VD and inulin mixture supplementation. The expressions of Vdr and Cyp27a1 were decreased by a maternal oxidized oil diet compared with the control group, while they could be increased by VD or VD and inulin mixture supplementation. Conclusion: maternal oxidized oil diet intake could impair the growth performance by inducing oxidative stress, but this can be relieved by maternal VD and inulin supplementation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Maternal Vitamin D and Inulin Supplementation in Oxidized Oil Diet Improves Growth Performance and Hepatic Innate Immunity in Offspring Mice

et al. 2023

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“…Simultaneously, DF consumption has been demonstrated to enhance maternal, placental, and fetal antioxidant defense capacities [150]. For instance, maternal long-term inulin intake improves the placental redox status and nutrient transport, mainly through favorable effects on the gut microbiota and metabolites [151]. Lin et al [152] demonstrated that DF supplementation is superior to N-acetylcysteine in limiting maternal serum and placental superoxide anion and hydroxyl radical scavenging, acting as an important antioxidant mechanism on the placenta.…”

Section: Fiber and Polyphenolsmentioning

confidence: 99%

Exploring the Role of Mediterranean and Westernized Diets and Their Main Nutrients in the Modulation of Oxidative Stress in the Placenta: A Narrative Review

García-Montero,

Fraile-Martinez,

De Leon-Oliva

et al. 2023

Antioxidants

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Oxidative stress is a major cellular event that occurs in the placenta, fulfilling critical physiological roles in non-pathological pregnancies. However, exacerbated oxidative stress is a pivotal feature of different obstetric complications, like pre-eclampsia, fetal growth restriction, and other diseases. Compelling evidence supports the relevant role of diet during pregnancy, with pleiotropic consequences for maternal well-being. The present review aims to examine the complex background between oxidative stress and placental development and function in physiological conditions, also intending to understand the relationship between different dietary patterns and the human placenta, particularly how this could influence oxidative stress processes. The effects of Westernized diets (WDs) and high-fat diets (HFDs) rich in ultra-processed foods and different additives are compared with healthy patterns such as a Mediterranean diet (MedDiet) abundant in omega 3 polyunsaturated fatty acids, monounsaturated fatty acids, polyphenols, dietary fiber, and vitamins. Although multiple studies have focused on the role of specific nutrients, mostly in animal models and in vitro, further observational and intervention studies focusing on the placental structure and function in women with different dietary patterns should be conducted to understand the precise influence of diet on this organ.

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Increased maternal consumption of methionine as its hydroxyl analog improves placental angiogenesis and antioxidative capacity in sows

Zhou,

Lai,

Yuan

et al. 2024

Preprint

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Background Previous evidence suggests that methionine (Met) consumption can promote placental angiogenesis and improve fetal survival. To investigate the mechanisms by which increased levels of Met as hydroxy-Met analogue (OHMet) improve placental function, forty sows were divided into four groups and fed with either a control diet (CON), 0.15%OHMet, 0.3%OHMet or 0.3%Met (n = 10). Placentas were collected immediately after expulsion, and extracted proteins were analyzed by tandem mass tag (TMT) based quantitative proteomic analysis. Results Here, we reported that 0.15%OHMet consumption significantly increased the placental vascular density compared with the CON group. Proteomic analysis identified 5136 proteins; of these, 87 differentially expressed proteins were screened (P < 0.05, |fold change| > 1.2). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched in 0.15%OHMet vs. CON and in 0.15%OHMet vs. 0.3%OHMet were glutathione metabolism, and in 0.15%OHMet vs. 0.3%Met were NOD-like receptor signaling pathway and apoptosis. Further analysis revealed that 0.15%OHMet supplementation upregulated the protein expression of glutathione-S-transferase (GSTT1) in placentas and trophoblast cells compared with the CON and 0.3%OHMet groups, upregulated the protein expression of thioredoxin (TXN) in placentas and trophoblast cells compared with the 0.3%OHMet and 0.3%Met groups, and decreased reactive oxygen species (ROS) levels in trophoblast cells compared with other groups. In contrast, sows fed 0.3%OHMet or 0.3%Met diets increased placental interleukin 1β levels compared with the CON group, and upregulated the protein expression of complex I-B9 (NDUFA3) compared with the 0.15%OHMet group. Furthermore, homocysteine, an intermediate in the trans-sulphuration pathway of methionine, was shown to damaged placental function by inhibiting the protein expression of TXN, and leading to apoptosis and ROS production. Conclusion In contrast to improved placental angiogenesis and increased antioxidative capacity by dietary 0.15%OHMet supplementation, 0.3%OHMet or 0.3%Met supplementation impaired placental function via aggravating inflammation and oxidative stress, which is associated to cumulative homocysteine levels.

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Maternal Long-Term Intake of Inulin Improves Fetal Development through Gut Microbiota and Related Metabolites in a Rat Model

Cited by 3 publications

References 81 publications

Maternal Vitamin D and Inulin Supplementation in Oxidized Oil Diet Improves Growth Performance and Hepatic Innate Immunity in Offspring Mice

Maternal Vitamin D and Inulin Supplementation in Oxidized Oil Diet Improves Growth Performance and Hepatic Innate Immunity in Offspring Mice

Exploring the Role of Mediterranean and Westernized Diets and Their Main Nutrients in the Modulation of Oxidative Stress in the Placenta: A Narrative Review

Increased maternal consumption of methionine as its hydroxyl analog improves placental angiogenesis and antioxidative capacity in sows

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