Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin

Agbota, Gino; Polman, Katja; Wieringa, Frank; Ponce, Maiza Campos; Yovo, Emmanuel; Roucher, Clémentine; Ezinmègnon, Sèm; Marcos, Javier Yugueros; Vachot, Laurence; Tissières, Pierre; Massougbodji, Achille; Fiévet, Nadine; Cot, Michel; Briand, Valérie

doi:10.1371/journal.pone.0222864

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…Evidence for an association between IPT in pregnancy and malaria in infants is limited (Kakuru, Staedke, Dorsey, Rogerson, & Chandramohan, 2019). Higher malaria risk has been reported in a single study of SGA infants, but gestational age was not assessed by ultrasound and the difference was marginal (Agbota, Polman, et al, 2019). Maternal–fetal immunological interactions are important (Feeney, 2020; Jagannathan, 2018).…”

Section: Discussionmentioning

confidence: 95%

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Risk of malaria in young children after periconceptional iron supplementation

Gies

Roberts

Diallo

et al. 2020

Maternal & Child Nutrition

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This study in Burkina Faso investigated whether offspring of young mothers who had received weekly periconceptional iron supplementation in a randomised controlled trial were at increased risk of malaria. A child safety survey was undertaken in the peak month of malaria transmission towards the end of the trial to assess child iron biomarkers, nutritional status, anaemia and malaria outcomes. Antenatal iron biomarkers, preterm birth, fetal growth restriction and placental pathology for malaria and chorioamnionitis were assessed. Data were available for 180 babies surviving to the time of the survey when their median age was 9 months. Prevalence of maternal iron deficiency in the last trimester based on low body iron stores was 16%. Prevalence of active placental malaria infection was 24.8%, past infection 59% and chorioamnionitis 55.6%. Babies of iron supplemented women had lower median gestational age. Four out of five children ≥ 6 months were iron deficient, and 98% were anaemic. At 4 months malaria prevalence was 45%. Child iron biomarkers, anaemia and malaria outcomes did not differ by trial arm. Factors associated with childhood parasitaemia were third trimester C-reactive protein level (OR 2.1; 95% CI 1.1-3.9), active placental malaria (OR 5.8; 1.0-32.5, P = 0.042) and child body iron stores (OR 1.13; 1.04-1.23, P = 0.002). Chorioamnionitis was associated with reduced risk of child parasitaemia (OR 0.4; 0.1-1.0, P = 0.038). Periconceptional iron supplementation of young women did not alter body iron stores of their children. Higher child body iron stores and placental malaria increased risk of childhood parasitaemia.

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Section: Discussionmentioning

confidence: 95%

“…Higher malaria risk has been reported in a single study of SGA infants, but gestational age was not assessed by ultrasound and the difference was marginal (Agbota, Polman, et al, 2019). Maternalfetal immunological interactions are important (Feeney, 2020;Jagannathan, 2018).…”

Section: Child Malaria Prevalence and Iron Biomarkers For Combined mentioning

confidence: 91%

Risk of malaria in young children after periconceptional iron supplementation

Gies

Roberts

Diallo

et al. 2020

Maternal & Child Nutrition

View full text Add to dashboard Cite

show abstract

“…We also consider that there may be a certain correlation between variables with no significant difference in univariate analysis and other confounding variables. To avoid the true effect of this variable being masked by the effect of other confounding indicators, all variables with p < 0.2 were included in the multivariate analysis [37], and then variables with p < 0.10 remained in the multivariate model after the stepwise backward selection process. The final report is presented as odds ratios (ORs) with 95% confidence intervals (95% CI) and significance levels (p-values).…”

Section: Discussionmentioning

confidence: 99%

Predicting the Occurrence of Advanced Schistosomiasis Based on FISHER Discriminant Analysis of Hematological Biomarkers

Yang

Xie

et al. 2022

Pathogens

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We established a model that predicts the possibility of chronic schistosomiasis (CS) patients developing into advanced schistosomiasis (AS) patients using special biomarkers that were detected in human peripheral blood. Blood biomarkers from two cohorts (132 CS cases and 139 AS cases) were examined and data were collected and analyzed by univariate and multivariate logistic regression analysis. Fisher discriminant analysis (FDA) for advanced schistosomiasis was established based on specific predictive diagnostic indicators and its accuracy was assessed using data of 109 CS. The results showed that seven indicators including HGB, MON, GLB, GGT, APTT, VIII, and Fbg match the model. The accuracy of the FDA was assessed by cross-validation, and 86.7% of the participants were correctly classified into AS and CS groups. Blood biomarker data from 109 CS patients were converted into the discriminant function to determine the possibility of occurrence of AS. The results demonstrated that the possibility of occurrence of AS and CS was 62.1% and 89.0%, respectively, and the accuracy of the established model was 81.4%. Evidence displayed that Fisher discriminant analysis is a reliable predictive model in the clinical field. It’s an important guide to effectively control the occurrence of AS and lay a solid foundation for achieving the goal of schistosomiasis elimination.

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Depression in the schistosomiasis japonica population based on the PHQ-9 scale: a cross-sectional survey from Jiangxi Province, China

Hu,

Liu,

Xie

et al. 2024

Sci Rep

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Depression is the second leading-cause of disability in China. Although studies have shown that more than 80% of patients with advanced schistosomiasis (AS) suffer from anxiety and depression, these study groups are all hospitalized patients with AS and do not represent the extent of the disease in the whole group. To our knowledge, there are no studies assessing the severity of depression in patients with other forms of schistosomiasis japonicum. Therefore, it is necessary to evaluate the occurrence and potential risk factors of depression in the schistosomiasis endemic population. This cross-sectional study was conducted in Jiangxi Province, where schistosomiasis is relatively common in China, as the investigation site. The Patient Health Questionnaire-9 (PHQ-9) scale was selected to assess the depressive symptoms in the study population. At the same time, basic personal information of the research subjects and relevant socio-economics and schistosomiasis endemic area indicators were collected. The survey results show that AS has the highest incidence of depression (34.35%), while non-advanced schistosomiasis (N-AS) and control group (CG) have 22.35% and 22.24% respectively; the incidence of depression in AS is significantly higher than in N-AS and CG, while there is no statistical significance in the comparison between N-AS and CG; the incidence of mild depressive symptoms accounts for 61.08%-75.54% of the total incidence of depression in different groups; multivariate analysis shows that the occurrence of moderate/severe depressive symptoms in the AS group was significantly related to above 60 years old, male, the combination of other serious diseases, personal financial difficulties, and marshland and lake endemic areas. In the N-AS group, the occurrence of moderate/severe depressive symptoms was significantly related to the combination of other serious diseases, personal financial difficulties, significant correlation between marshland and lake endemic areas and the level of control of schistosomiasis epidemics. In conclusion, depression is still relatively common among patients with schistosomiasis patients, especially those with AS. It is recommended that the government and relevant departments consider mental health care when developing prevention and control work in schistosomiasis-endemic areas, in order to effectively protect the physical and mental health of schistosomiasis patients and residents in endemic areas.

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Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin

Abstract: Background Malaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. Few studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant's risk of infection.

Cited by 6 publications

References 29 publications

Risk of malaria in young children after periconceptional iron supplementation

Risk of malaria in young children after periconceptional iron supplementation

Predicting the Occurrence of Advanced Schistosomiasis Based on FISHER Discriminant Analysis of Hematological Biomarkers

Depression in the schistosomiasis japonica population based on the PHQ-9 scale: a cross-sectional survey from Jiangxi Province, China

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