Maternal melatonin supplementation shapes gut microbiota and protects against inflammation in early life

Li, Fēi; Lai, Jianguo; Ma, Fei; Cai, Yao; Li, Sitao; Feng, Zhoushan; Lu, Zhengdong; Xiao, Ling; Qin, Ke; Hu, Hao; Xiao, Xueshan

doi:10.1016/j.intimp.2023.110359

Cited by 6 publications

(5 citation statements)

References 64 publications

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“…It was demonstrated to regulate GM dysbiosis, which reduced GIT inflammation in experimental settings [ 49 ]. A recent study done on an experimental group of mice has shown that the appropriate maternal intake of melatonin can influence the gut microbiota of the offspring in mice and can protect them from early-life inflammatory diseases [ 50 ]. Moreover, the therapeutic effect of melatonin was also noticed due to its ability to modulate GM by enhancing eubiosis, which eventually improves the outcomes of dysbiosis-related diseases like IBD [ 37 ].…”

Section: Melatonin and Gm Interplaymentioning

confidence: 99%

Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer

Jurjus,

El Masri,

Ghazi

et al. 2024

Nutrients

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Inflammatory bowel disease (IBD), a continuum of chronic inflammatory diseases, is tightly associated with immune system dysregulation and dysbiosis, leading to inflammation in the gastrointestinal tract (GIT) and multiple extraintestinal manifestations. The pathogenesis of IBD is not completely elucidated. However, it is associated with an increased risk of colorectal cancer (CRC), which is one of the most common gastrointestinal malignancies. In both IBD and CRC, a complex interplay occurs between the immune system and gut microbiota (GM), leading to the alteration in GM composition. Melatonin, a neuroendocrine hormone, was found to be involved with this interplay, especially since it is present in high amounts in the gut, leading to some protective effects. Actually, melatonin enhances the integrity of the intestinal mucosal barrier, regulates the immune response, alleviates inflammation, and attenuates oxidative stress. Thereby, the authors summarize the multifactorial interaction of melatonin with IBD and with CRC, focusing on new findings related to the mechanisms of action of this hormone, in addition to its documented positive outcomes on the treatment of these two pathologies and possible future perspectives to use melatonin as an adjuvant therapy.

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Section: Melatonin and Gm Interplaymentioning

confidence: 99%

Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer

Jurjus,

El Masri,

Ghazi

et al. 2024

Nutrients

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“…The experimental operation flow and animal handling were both approved by the Institutional Animal Care and Use Committee of Guangxi Medical University. To verify the role of hub genes in the septic lung, 12 mice were intraperitoneally injected with lipopolysaccharide (LPS, 20 mg/kg), 15 and another 12 mice were received equivoluminal phosphate buffer saline (PBS) by intraperitoneal injection. After the treatment with LPS injection 24 h, the right primary bronchi in the trachea carina was ligatured, and then the left lung bronchoalveolar lavage was harvested by douching with ice-cold PBS.…”

Section: Animal Models and Sample Collectionmentioning

confidence: 99%

Identification of potential biomarkers for nonsurvivor sepsis patients via microarray technology: A study based on GEO datasets

Ma,

Shan,

Luo

et al. 2023

Eur J Inflamm

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Background: The mechanism of sepsis especially non-survivors has not yet been identified. Objective: To identify the key genes concerned with non-survivor sepsis (NSS) and analyze its molecular mechanism. Methods: The original data were obtained from the GEO database to screen deferentially expressed genes (DEGs). GO and KEGG analysis were performed to analyze the functional annotation of DEGs. The protein-protein interaction (PPI) network and related analysis of hub genes were carried out. Further, hub genes were confirmed in the lipopolysaccharide (LPS)-induced septic mice by western blotting and immunohistochemistry. Results: We obtained 188 DEGs and 32 hub genes between NSS patients and healthy volunteers. Among of them, the top 10 hub genes including STAT1, ISG15, HERC1, EIF2AK2, RPL27, LY6E, IFI44L, XAF1, RSAD2 and HERC6 were studied, which predict sepsis based on receiver operator characteristic curve analysis. These hub genes were enriched in positive regulation of biomedical process including translation, response to virus and suppression of mitochondrial depolarization, etc.; cell component including mitochondrial inner membrane; molecular function containing ligase activity, etc. These hub genes are also enriched in influenza A infection and leukocyte trans-endothelial migration. The expression of these hub genes is better involved in a diagnosis of NSS, such as HERC6 (AUC = 0.9753, p = .0007), RPL27 (AUC = 0.9691, p = .0008), ISG15 (AUC = 0.9630, p = .0009), STAT1 (AUC = 0.9383, p = .0017), HERC1 (AUC = 0.9259, p = .0023), and XAF1 (AUC = 0.9259, p = .0023). Furthermore, 20 mg/kg of LPS injection up-regulated the expression of ISG15, RPL27, LY6E and HERC6 in the lung tissues compared with control mice. Conclusion: These identified 188 DEGs and 10 hub genes were associated with NSS, especially ISG15, RPL27, LY6E and HERC6 genes expressed in the lung as the most vulnerable organ.

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“…A healthy intestinal microbiota and reduced circulating LPS/endotoxemia would facilitate melatonin-protective antioxidant functions and improve chronic inflammation ( 24 ). Of note, maternal melatonin supplementation had a significant effect on the intestinal microbiota and decreased inflammatory mediators in the offspring following LPS injection ( 34 ). Accumulating evidence supports endogenous melatonin's influence on the intestinal microbiome, homeostasis, and stress resistance ( 33 ), suggesting that its reduction is a risk factor for EED complications.…”

Section: Gut-derived Melatonin May Be Affected By Intestinal Microbio...mentioning

confidence: 99%

The double burden of malnutrition and environmental enteric dysfunction as potential factors affecting gut-derived melatonin in children under adverse environments

Bezerra,

Peixoto,

Lopes

et al. 2023

Front. Nutr.

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Graphical Abstract Poor environmental conditions combined with continuous unhealthy and unsafe diets may substantially increase the risk of a vicious cycle of enteric infections (EED–environmental enteric dysfunction) and malnutrition (DBM–double burden of malnutrition) in children. Gut melatonin, mainly produced by the intestinal microbiota, can modulate the composition, variety, and dynamics of the microbiota itself and may affect and be affected by intestinal microbiota alterations due to DBM and EED.

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Maternal melatonin supplementation shapes gut microbiota and protects against inflammation in early life

Cited by 6 publications

References 64 publications

Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer

Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer

Identification of potential biomarkers for nonsurvivor sepsis patients via microarray technology: A study based on GEO datasets

The double burden of malnutrition and environmental enteric dysfunction as potential factors affecting gut-derived melatonin in children under adverse environments

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