Maternal methyl supplements increase offspring DNA methylation at <i>Axin fused</i>

Waterland, Robert A.; Dolinoy, Dana C.; Lin, Juan; Smith, Chris; Shi, Xiaorui; Tahiliani, Kajal G.

doi:10.1002/dvg.20230

Cited by 454 publications

(333 citation statements)

References 24 publications

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“…Interestingly though, the DNA methylation status, gene expression and phenotype related to both these gene loci can be modified by dietary methyl donor supplementation in early development. 39,40 There is a recent report that nutritional supplementation can lead to germline epigenetic modification in agoutimouse model. 35 The three reports of TGRs in humans show some concordance in outcome in the descendants.…”

Section: Discussionmentioning

confidence: 99%

Transgenerational response to nutrition, early life circumstances and longevity

et al. 2007

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Nutrition might induce, at some loci, epigenetic or other changes that could be transmitted to the next generation impacting on health. The slow growth period (SGP) before the prepubertal peak in growth velocity has emerged as a sensitive period where different food availability is followed by different transgenerational response (TGR). The aim of this study is to investigate to what extent the probands own childhood circumstances are in fact the determinants of the findings. In the analysis, data from three random samples, comprising 271 probands and their 1626 parents and grandparents, left after exclusions because of missing data, were utilized. The availability of food during any given year was classified based on regional statistics. The ancestors' SGP was set at the ages of 8-12 years and the availability of food during these years classified as good, intermediate or poor. The probands' childhood circumstances were defined by the father's ownership of land, the number of siblings and order in the sibship, the death of parents and the parents' level of literacy. An earlier finding of a sex-specific influence from the ancestors' nutrition during the SGP, going from the paternal grandmother to the female proband and from the paternal grandfather to the male proband, was confirmed. In addition, a response from father to son emerged when childhood social circumstances of the son were accounted for. Early social circumstances influenced longevity for the male proband. TGRs to ancestors' nutrition prevailed as the main influence on longevity.

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Section: Discussionmentioning

confidence: 99%

Transgenerational response to nutrition, early life circumstances and longevity

et al. 2007

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“…This concept of a retro-element triggered ME was confirmed in the murine Axin Fu mutation, at which interindividual variation in methylation is associated with tail kinking (Rakyan et al, 2002). It was shown that methylation at MEs occurs stochastically but can in part be modified by maternal intake of nutrients related to one-carbon metabolism (Waterland et al, 2006;Waterland and Jirtle, 2003). In addition the methylation state can in part be transmitted via a parental germline, either maternal (A vy ) (Morgan et al, 1999) or paternal (Axin Fu ) (Rakyan et al, 2003).…”

Section: Introductionmentioning

confidence: 90%

Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity

et al. 2016

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Interindividual variation in DNA methylation at a putative POMC metastable epiallele is associated with obesity, Cell Metabolism (2016Metabolism ( ), doi: 10.1016Metabolism ( /j.cmet.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Introduction: POMC-gene

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“…However, the extent to which the modification is perpetuated is by simple persistence of the environmental factors that bring about the epigenetic modification; that is, in each generation individuals are exposed to the same conditions. For example, if the diet [112,29] or environmental toxicant such as lead continues to be present in the environment, then the epigenetic modification will be manifest each generation. This type of epigenetic modification lends itself to relatively straightforward therapeutic venues such as providing methyl donors to the diet [112] or removing the environmental toxicant (smoke or lead).…”

Section: Context-dependent Epigenetic Modificationmentioning

confidence: 99%

Epigenetics and its implications for behavioral neuroendocrinology

Crews

2008

Frontiers in Neuroendocrinology

146

115

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Individuals vary in their sociosexual behaviors and reactivity. How the organism interacts with the environment to produce this variation has been a focus in psychology since its inception as a scientific discipline. There is now no question that cumulative experiences throughout life history interact with genetic predispositions to shape the individual's behavior. Recent evidence suggests that events in past generations may also influence how an individual responds to events in their own life history. Epigenetics is the study of how the environment can affect the genome of the individual during its development as well as the development of its descendants, all without changing the DNA sequence. Several distinctions must be made if this research is to become a staple in behavioral neuroendocrinology. The first distinction concerns perspective, and the need to distinguish and appreciate, the differences between Molecular versus Molar epigenetics. Each has its own lineage of investigation, yet both appear to be unaware of one another. Second, it is important to distinguish the difference between Context-Dependent versus Germline-Dependent epigenetic modifications. In essence the difference is one of the mechanism of heritability or transmission within, as apposed to across, generations. This review illustrates these distinctions while describing several rodent models that have shown particular promise for unraveling the contribution of genetics and the environment on sociosexual behavior. The first focuses on genetically-modified mice and makes the point that the early litter environment alters subsequent brain activity and behavior. This work emphasizes the need to understand behavioral development when doing research with such animals. The second focuses on a new rat model in which the epigenome is permanently imprinted, an effect that crosses generations to impact the descendants without further exposure to the precipitating agent. This work raises the question of how events in generations past can have consequences at both the mechanistic, behavioral, and ultimately evolutionary levels.

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Maternal methyl supplements increase offspring DNA methylation at Axin fused

Cited by 454 publications

References 24 publications

Transgenerational response to nutrition, early life circumstances and longevity

Transgenerational response to nutrition, early life circumstances and longevity

Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity

Epigenetics and its implications for behavioral neuroendocrinology

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