Maternal microbiome and pregnancy outcomes

Fox, Chelsea; Eichelberger, Kacey Y.

doi:10.1016/j.fertnstert.2015.09.037

Cited by 123 publications

(106 citation statements)

References 67 publications

(124 reference statements)

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“…Aagaard et al, however, suggested that the stability of the vaginal microbiome in pregnancy provides an adaptive benefit to reproductive health . According to Fox and Eichelberger, at the end of pregnancy, the composition of the vaginal microbiota becomes more similar to that of non‐pregnant women. On the other hand, DiGiulio et al reported significant differences in the composition of the vaginal microbiota in the post‐partum period but no changes with advancing gestational age.…”

Section: The Vaginal Microbiome During Pregnancymentioning

confidence: 99%

“…Some experimental studies have found that the microbial community detected in amniotic fluid and placental samples may have originated in the oral cavity . Other investigators have shown an association between periodontal disease and PTB . Doyle et al analyzed placental tissue samples from 1390 Malawi women using 16S rRNA gene sequencing.…”

Section: Microbiome and Obstetric Disordersmentioning

confidence: 99%

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Microbiome in normal and pathological pregnancies: A literature overview

Taddei

Cortez

Mattar

et al. 2018

American J Rep Immunol

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This review summarizes recent findings on the changes that occur during pregnancy in the composition of the vaginal and gut microbiome and their association with metabolic, hormonal, and immunological factors. Despite many studies on the topic, the vaginal and gut microbial profiles and their influence on the course of pregnancy are still unclear. We present data suggesting that, contrary to traditional understanding, the placenta is not sterile but has a microbial community. We review and discuss new findings on changes in the richness and diversity of the microbiota of pregnant women with term or preterm births, obesity, and gestational diabetes mellitus. Several factors influence the bacterial profile of these women and may explain, at least in part, some of the discrepant findings between studies. The development of and access to new molecular biology methods and techniques has expanded the possibilities of research. This will contribute to a better understanding of the microbiome and its role in normal and pathological pregnancies.

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Section: The Vaginal Microbiome During Pregnancymentioning

confidence: 99%

Section: Microbiome and Obstetric Disordersmentioning

confidence: 99%

Microbiome in normal and pathological pregnancies: A literature overview

Taddei

Cortez

Mattar

et al. 2018

American J Rep Immunol

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“…During pregnancy, the maternal body undergoes radical physiological fluctuations in hormones and immune status [Fox and Eichelberger, 2015]. Recent studies have found that these changes are concurrent with alterations in the maternal gut microbiome, with significant shifts occurring from the first to the third trimester [Koren et al, 2012].…”

Section: Maternal Microbiome During Pregnancymentioning

confidence: 99%

Dysbiosis in Children Born by Caesarean Section

Garcia¹,

Yee²,

Gilbert³

et al. 2018

Ann Nutr Metab

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The rate of Caesarean-section delivery in the United States has increased by 60% from 1996 through to 2013 and now accounts for > 30% of births [CDC, 2017]. The purpose of this review is to present the current understanding of both the microbial risk factors that increase the likelihood of a Caesarean-section delivery and the microbial dysbiosis that is thought to result from the Caesarean section. We provide examples of research into the impact of early-life microbial dysbiosis on infant development and long-term health outcomes, as well as consider the efficacy and the long-term implications of microbiome-based therapies to mitigate this dysbiosis. The steep rise in the Caesarean-section delivery rate makes it imperative to understand the potential of microbiota modulation for the treatment of dysbiosis.

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“…These reciprocal relationships include the direct induction of both maternal and neonatal physiological changes so that ecological relationships within varying tissues are changed. Crucially, since this process begins before birth and then continues thereafter, it is not surprising that changes in the maternal microbiome are now being linked to a variety of differing pregnancy outcomes and pre-term birth (71). …”

Section: The Impact Of the Microbiome On Developmentmentioning

confidence: 99%

The Eukaryotic Microbiome: Origins and Implications for Fetal and Neonatal Life

Miller

2016

Front. Pediatr.

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All eukaryotic organisms are holobionts representing complex collaborations between the entire microbiome of each eukaryote and its innate cells. These linked constituencies form complex localized and interlocking ecologies in which the specific microbial constituents and their relative abundance differ substantially according to age and environmental exposures. Rapid advances in microbiology and genetic research techniques have uncovered a significant previous underestimate of the extent of that microbial contribution and its metabolic and developmental impact on holobionts. Therefore, a re-calibration of the neonatal period is suggested as a transitional phase in development that includes the acquisition of consequential collaborative microbial life from extensive environmental influences. These co-dependent, symbiotic relationships formed in the fetal and neonatal stages extend into adulthood and even across generations.

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Maternal microbiome and pregnancy outcomes

Cited by 123 publications

References 67 publications

Microbiome in normal and pathological pregnancies: A literature overview

Microbiome in normal and pathological pregnancies: A literature overview

Dysbiosis in Children Born by Caesarean Section

The Eukaryotic Microbiome: Origins and Implications for Fetal and Neonatal Life

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