2021
DOI: 10.3389/fimmu.2021.683022
|View full text |Cite
|
Sign up to set email alerts
|

Maternal Microbiota, Early Life Colonization and Breast Milk Drive Immune Development in the Newborn

Abstract: The innate immune system is the oldest protection strategy that is conserved across all organisms. Although having an unspecific action, it is the first and fastest defense mechanism against pathogens. Development of predominantly the adaptive immune system takes place after birth. However, some key components of the innate immune system evolve during the prenatal period of life, which endows the newborn with the ability to mount an immune response against pathogenic invaders directly after birth. Undoubtedly,… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
69
0
1

Year Published

2021
2021
2024
2024

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 103 publications
(70 citation statements)
references
References 266 publications
(340 reference statements)
0
69
0
1
Order By: Relevance
“…As mentioned earlier, iatrogenic factors such as antibiotic use can disrupt microbiome progression [ 41 ]. More broadly, early life microbiome disruption has been implicated in the development of autoimmune disease in mouse models [ 244 ], and has been associated with lasting metabolic and autoimmune disease consequences in observational studies [ 245 , 246 , 247 , 248 ].…”
Section: Microbiome Modulation With Prebioticsmentioning
confidence: 99%
“…As mentioned earlier, iatrogenic factors such as antibiotic use can disrupt microbiome progression [ 41 ]. More broadly, early life microbiome disruption has been implicated in the development of autoimmune disease in mouse models [ 244 ], and has been associated with lasting metabolic and autoimmune disease consequences in observational studies [ 245 , 246 , 247 , 248 ].…”
Section: Microbiome Modulation With Prebioticsmentioning
confidence: 99%
“…Moreover, milk is essential for infant mammals: it provides nutrition and helps the development of the neonatal gut immune system through maternal immunoglobulin transmission [43,44]. Recently, EVs' described immunomodulation role has also been confirmed in mEVs, accompanied by anti-inflammatory functions [45,46], suggesting a sort of adjuvant activity in the newborn immune system shaping. In fact, mEVs are rich in bioactive molecules such as proteins, lipids, RNAs, and metabolites, which also emerged from our previous studies, known to influence inflammation and the immune system [47][48][49].…”
Section: Introductionmentioning
confidence: 99%
“…Another striking feature is the enhanced endocytosis capacity of immature intestinal epithelial cells shortly after birth [23], which might give rise to a sensitization of the appropriate immune cells leading to an upregulation of immune markers. With respect to a difference in development between the innate and the adaptive component of immunity, the observation that the development of the latter starts at birth whereas that of innate immunity already during pregnancy [24] might be of importance here. This timing of the innate component enables the newborn to combat potential pathogens effectively from birth onwards.…”
Section: Discussionmentioning
confidence: 95%