Maternal Mortality From Preeclampsia/Eclampsia

Ghulmiyyah, Labib; Sibai, Bahaeddine M

doi:10.1053/j.semperi.2011.09.011

Cited by 712 publications

(539 citation statements)

References 34 publications

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“…The prevalence of preeclapsia was reported, in Iran, between 1-12% in accordance with according to the scattered studies [3,4]. This syndrome is associated with bleeding and death-threatening infections, and includes a large proportion of morbidity and mortality in the pregnancy [5]. Preeclampsia is considered as the third leading cause of maternal mortality in the world and the second common cause of maternal mortality in Iran [6] which is allocated 18% of the maternal mortality in Iran [7].…”

Section: Introductionsupporting

confidence: 52%

The Examination of the Risk factors for Pre-Eclampsia in the Pregnant Coming to Fatemiyeh Hospital, Hamadan, 2005-2015 (Retrospective Case-Control Study)

2017

Int. J. Adv. Res. Biol. Sci

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The present study was carried out and aimed to examine the risk factors of preeclampsia, which is the common disorder of pregnancy, to carry out the precautionary measures, due to its high prevalence and serious side-effects of this syndrome. This is a retrospective case -control study which was conducted by using existing cases in Fatemiyeh Hospital, Hamadan during 2005-2015. The Data collection method was done through referring to the existing cases in Fatemiyeh Hospital, and extracting the information related to patients with Preeclampsia and without Preeclampsia. Thus, 726 pregnant with Preeclampsia were included in case group and the same number of pregnant without Preeclampsia were put in the control group. Then the required data was collected through a researcher made questionnaire. SPSS 21 software and chi-square test and logistic regression were used to analyze the data. Significance level was considered lower than 0.05. Majority of women in case and control group were at the age range of 39 -40 years old. Findings of the current study showed that there is a significant relationship between the occurrence of Preeclampsia and increasing age, low Apgar score in infant, history of previous blood pressure, first pregnancy and delivery, and male gender (P<0.05). As there is a relationship between the occurrence of Preeclampsia and increasing age, the history of prior blood pressure, null parity and the male gender, that was important that the necessary measurements to recognize the pregnant exposed to the risk were considered to control and prevent.

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Section: Introductionsupporting

confidence: 52%

The Examination of the Risk factors for Pre-Eclampsia in the Pregnant Coming to Fatemiyeh Hospital, Hamadan, 2005-2015 (Retrospective Case-Control Study)

2017

Int. J. Adv. Res. Biol. Sci

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“…Pregnancy-induced hypertension (PIH) is associated with the various problems in pregnancy outcome. The complications of high blood pressure (BP) during pregnancy are detrimental [1]. The elevated or uncontrolled BP leads to early and cesarean delivery also caused various complications to both mother and fetus.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Treatment Outcome of Antihypertensive Drugs in the Management of Pregnancy Induced Hypertension

Velusamy

2017

Int J Pharm Pharm Sci

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This study was aimed to find out the differences in the pregnancy outcome of PIH women treated with the antihypertensive drugs methyldopa and nifedipine. The prospective observational study was conducted in a multi specialty hospital at Coimbatore with 161 PIH diagnosed women. Women were categorised into the no-drug group, methyldopa group, nifedipine group and methyldopa with nifedipine group. All the women were monitored from diagnosis to delivery. The maternal and neonatal data were collected and analysed. The drugs were significantly controlled the blood pressure (BP) from base to end (P<0.001). There was no significant difference in the reduction of BP between the drugs. Cesarean delivery (>90%) and preterm delivery were high across all the groups. No significant difference was seen between these groups. The AGA (Average for gestational age) babies were significantly higher with a no-drug group (83%) and lower with nifedipine group (40%). Two women were reported with HELLP syndrome in methyldopa with nifedipine group. No significant difference was found in terms of pregnancy outcome between these groups except for eclampsia and AGA. Eclampsia was affected more with 14% in methyldopa with nifedipine group. We found similar outcomes; there were no significant changes between methyldopa, nifedipine, and the no-drug treatment. The antihypertensive drugs nifedipine and methyldopa both were significantly reduced the BP. The maternal and neonatal complications were similar between these two drugs. No beneficial effect can be identified one over another. Pregnancy-induced hypertension (PIH) is associated with the various problems in pregnancy outcome. The complications of high blood pressure (BP) during pregnancy are detrimental [1]. The elevated or uncontrolled BP leads to early and cesarean delivery also caused various complications to both mother and fetus. Indeed, the PIH resolves postpartum it causes various maternal and fetal morbidity and mortality [2]. Growth retardation and fetal mortality are the serious complications in PIH pregnancy. The development of PIH often required medications to control the BP. Antihypertensive drugs are used to control the BP within the normal range which further reduces the PIH related complications. Although various drugs are used to treat the PIH, the benefits of antihypertensive medication in PIH is inconsistent [3] and the use of antihypertensive medication as well as treatment targets in PIH remains controversial [4]. The chosen drug should be safe and effective to both mother and fetus in terms of reduction in PIH complications. Hence this study was planned to find out the differences in treatment outcome between the different types of antihypertensive drugs used in the treatment of PIH.The study was approved by the Institutional ethics committee (EC/AP/102/09-2009, Date: 12-08-2009) at kovai medical center and hospital, Coimbatore, Tamilnadu, India. The observational study was carried out at kovai medical center and hospital from January 2009 to December 2014. A ...

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“…It is a rapidly progressive condition characterized by proteinuria, hypertension and edema [1]. Despite advances in the management of preeclampsia, it is still the main cause of maternal and perinatal mortality, complicating 5-10% of pregnancies worldwide [2]. Although intensive research has been performed on the molecular changes associated with PE, the etiology and pathogenic mechanisms of PE remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Role of Placental Mitochondria in Development of Pre-eclampsia: Focus on Mitochondrial Dynamics, Redox Signaling and Apoptosis

Zakaria¹,

Gaballah²,

Hagras³

2018

BESPS

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Background: M itochondrial dysfunction has been incriminated in the pathogenesis of preeclampsia (PE). Th is study aimed at evaluating the contribution of mitochondrial dynamics, biogenesis, redox signaling and apoptosis in the pathogenesis of mitochondrial dysfunction in pre-eclamptic placenta. Forty pregnant females were classified equally into two groups: Group І (control group), included normotensive pregnant females and Group ІІ (PE group) included, preeclamptic pregnant females. After delivery, placental tissue samples were collected for estimation of mRNA expression levels of Mitofusin2 (Mfn2) using qu antitative real-time PCR . Dynamin related protein 1 (Drp 1), mitochondrial Cytochrome c release ,and 3-nitrotyrosine (3-NT) were measured by ELISA . M itochondrial co mplex I, and citrate synthase enzyme activity were assessed spectrophotometrically. ATP levels, Caspase-9 activity , inorganic nitrites and nitrate levels ,and superoxide dismutase (SOD) activ ity were measured by colorimetric assay kit. Preeclamptic placentae showed significant decrease in complex I, ATP levels and citrate synthase activity. mRNA expression of Mfn 2 were down regulated with marked elevation of DRP1 protein levels .There were altered redox status as judged by the elevation of NO and protein nitration with reduction in the total SOD activity in pre-eclamptic placentae. There were also activation of the mitochondrial pathway of apoptosis as judged by release of cytochrome c fro m the mitochondrial intermembrane space into the cytosol and significant increase in caspase -9 levels in Pre-eclampt ic placentae compared to controls. Our data strongly nominated significant association between mitochondrial dysfunction, disturbed dynamics, altered redo x status and the susceptibility to apoptosis in pre-eclamptic placenta as key players in the multifactorial pathogenic mechanis ms of PE

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Maternal Mortality From Preeclampsia/Eclampsia

Cited by 712 publications

References 34 publications

The Examination of the Risk factors for Pre-Eclampsia in the Pregnant Coming to Fatemiyeh Hospital, Hamadan, 2005-2015 (Retrospective Case-Control Study)

The Examination of the Risk factors for Pre-Eclampsia in the Pregnant Coming to Fatemiyeh Hospital, Hamadan, 2005-2015 (Retrospective Case-Control Study)

Comparison of Treatment Outcome of Antihypertensive Drugs in the Management of Pregnancy Induced Hypertension

Role of Placental Mitochondria in Development of Pre-eclampsia: Focus on Mitochondrial Dynamics, Redox Signaling and Apoptosis

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