Maternal motivation of lactating rats is disrupted by low dosages of haloperidol

Stern, Judith M.; Keer, Stephanie

doi:10.1016/s0166-4328(98)00108-9

Cited by 77 publications

(48 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pharmacological approaches have found that systemic and central NAc injections of DA agonists and antagonists affect different aspects of maternal behavior in rats (Giordano et al 1990;Keer and Stern 1999;Silva et al 2001;Stern and Keer 1999;Stern and Protomastro 2000;Vernotica et al 1999).…”

Section: Introductionmentioning

confidence: 99%

The reward system and maternal behavior in an animal model of depression: a microdialysis study

et al. 2007

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

The reward system and maternal behavior in an animal model of depression: a microdialysis study

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Dopamine system stimulation through the use of agonists, particularly D2 receptor agonists, has been shown to promote the release of peripheral oxytocin (Amico et al, 1992(Amico et al, , 1993Crowley et al, 1992;Parker and Crowley, 1992), while administration of dopamine antagonists results in a significant disruption in pup retrieval, nest building, and motor activity in general (Byrnes et al, 2002;Giordano et al, 1990;Keer and Stern, 1999;Silva et al, 2001Silva et al, , 2003Stern and Keer, 1999). As Stern and Keer (1999) suggest, this could potentially be due to the dopamine system involvement in motivation and reward. A 1.5 mg/kg dose of the dopaminergic reuptake inhibitor, amfonelic acid, enhanced maternal behaviors on postpartum day (PPD) 1 and decreased maternal aggression on PPD 6 in gestationally treated rat dams and oxytocin levels were significantly increased in the amygdala of the less aggressive AFA treated dams on PPD 8 (Johns et al, 1995(Johns et al, , 1996.…”

Section: Introductionmentioning

confidence: 99%

The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat

Johns

Joyner

McMurray

et al. 2005

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Studies using dopaminergic and serotonergic agonists or antagonists implicate involvement of these systems in various aspects of early maternal behavior and postpartum aggression towards an intruder in rats, both of which are associated with the presence of oxytocin in specific brain regions. It is unclear however, if or how long-term uptake inhibition of either neurotransmitter system alone or in combination, affects oxytocin system dynamics or maternal behavior/ aggression. Pregnant women frequently take drugs (antidepressants, cocaine) that induce longterm reuptake inhibition of dopamine and/or serotonin, thus it is important to understand these effects on behavior and biochemistry. Rat dams were treated throughout gestation with amfonelic acid, fluoxetine, or a combination of both, to investigate effects of reuptake inhibition of dopamine and serotonin systems respectively, on maternal behavior, aggression and oxytocin. The more appetitive aspects of maternal behavior (nesting, licking, touching) and activity were increased by the low dose of amfonelic acid, high dose of fluoxetine, or the high dose combination more than other treatments. Aggression was decreased by amfonelic acid and somewhat increased by fluoxetine. Dopamine uptake inhibition appears to have a strong effect on hippocampal oxytocin levels, while receptor dynamics may be more strongly affected by serotonin uptake inhibition.

show abstract

“…Manipulations of the dopamine system have been strongly associated with alterations in various aspects of maternal behavior and affect aspects of oxytocin. D2 receptor agonists particularly promote the release of peripheral oxytocin (Amico et al, 1992;Amico et al, 1993;Crowley et al, 1992;Parker and Crowley, 1992), while administration of dopamine antagonists results in a significant disruption in pup retrieval, nest building, and motor activity in general (Byrnes et al, 2002;Giordano et al, 1990;Keer and Stern, 1999;Silva et al, 2001;Silva et al, 2003;Stern and Keer, 1999).…”

Section: Discussionmentioning

confidence: 99%

Impact of gestational cocaine treatment or prenatal cocaine exposure on early postpartum oxytocin mRNA levels and receptor binding in the rat

et al. 2008

View full text Add to dashboard Cite

Prior research reported decreased oxytocin levels in specific brain regions correlated with disruptions in maternal care following gestational cocaine treatment in rats. Similarly, prenatal exposure to cocaine impaired subsequent maternal behavior in adulthood, but behavioral alterations were not associated with decreases in oxytocin levels in the same brain regions as were found in their cocainetreated rat dams. To determine if other aspects of the oxytocin system are disrupted by cocaine treatment or prenatal exposure to cocaine during critical time points associated with maternal care, oxytocin mRNA transcription and receptor binding were examined on postpartum day two in relevant brain regions following gestational treatment with, or prenatal exposure to, either cocaine or saline. We hypothesized that oxytocin mRNA levels and receptor binding would be differentially affected by cocaine in the early postpartum period of dams and their offspring. Our findings indicate that gestational cocaine treatment resulted in significant increases in oxytocin mRNA levels in only the paraventricular nucleus of cocaine-treated dams, with almost significant increases in both generations in the supraoptic nucleus, but no significant effects of cocaine on receptor binding in either generation of dams. These findings indicate that in addition to oxytocin levels, cocaine treatment or prenatal exposure primarily affects oxytocin mRNA synthesis, with little effect on receptor binding in specific brain regions associated with maternal behavior in the early postpartum period of the rat.

show abstract

Maternal motivation of lactating rats is disrupted by low dosages of haloperidol

Cited by 77 publications

References 48 publications

The reward system and maternal behavior in an animal model of depression: a microdialysis study

The reward system and maternal behavior in an animal model of depression: a microdialysis study

The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat

Impact of gestational cocaine treatment or prenatal cocaine exposure on early postpartum oxytocin mRNA levels and receptor binding in the rat

Contact Info

Product

Resources

About