Maternal mumps antibodies in a cohort of children up to the age of 1 year

Leuridan, Elke; Goeyvaerts, Nele; Hens, Niel; Hutse, Veronik; Damme, Pierre Van

doi:10.1007/s00431-012-1691-y

Cited by 17 publications

(3 citation statements)

References 35 publications

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“…Passive loss of IgG and IgG subclasses follows a logarithmic function [11,12] – in our study with the decay constant λ of 1.07. The calculation of the biological half life of total IgG in CLL patients with the use of this constant may allow the prediction of the time when IgG levels are critically low and risk for opportunistic infections is high.…”

Section: Discussionmentioning

confidence: 99%

“…These antigen-specific antibody titers decrease passively (decay) after clearance of the virus from the circulation but may be boosted upon re-exposure to the specific antigen in the course of reactivation or reinfection with a different CMV genotype [10]. In the absence of immunological boosts, virus-specific antibodies decay exponentially [11,12]. However, knowledge about the kinetic of virus-specific antibodies in association with that of total antibody levels is very limited in healthy individuals and CLL patients.…”

Section: Introductionmentioning

confidence: 99%

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Chronic Lymphocytic Leukemia Patients Have a Preserved Cytomegalovirus-Specific Antibody Response despite Progressive Hypogammaglobulinemia

et al. 2013

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Chronic lymphocytic leukemia (CLL) is characterized by progressive hypogammaglobulinemia predisposing affected patients to a variety of infectious diseases but paradoxically not to cytomegalovirus (CMV) disease. Moreover, we found reactivity of a panel of CLL recombinant antibodies (CLL-rAbs) encoded by a germ-line allele with a single CMV protein, pUL32, despite differing antibody binding motifs. To put these findings into perspective, we studied prospectively relative frequency of viremia, kinetics of total and virus-specific IgG over time, and UL32 genetic variation in a cohort of therapy-naive patients (n=200). CMV-DNA was detected in 3% (6/200) of patients. The decay of total IgG was uniform (mean, 0.03; SD, 0.03) and correlated with that of IgG subclasses 1-4 in the paired samples available (n=64; p<0.001). Total CMV-specific IgG kinetics were more variable (mean, 0,02; SD, 0,06) and mean decay values differed significantly from those of total IgG (p=0.034). Boosts of CMV-specific antibody levels were observed in 49% (22/45) of CMV-seropositive patients. In contrast, VZV- and EBV-specific IgG levels decayed in parallel with total IgG levels (p=0.003 and p=0.001, respectively). VZV-specific IgG even became undetectable in 18% (9/50) of patients whereas CMV-specific ones remained detectable in all seropositive patients. The observed CMV-specific IgG kinetics were predicated upon the highly divergent kinetics of IgG specific for individual antigens - glycoprotein B-specific IgG were boosted in 51% and pUL32-specific IgG in 32% of patients. In conclusion, CLL patients have a preserved CMV-specific antibody response despite progressive decay of total IgG and IgG subclasses. CMV-specific IgG levels are frequently boosted in contrast to that of other herpesviruses indicative of a higher rate of CMV reactivation and antigen-presentation. In contrast to the reactivity of multiple different CLL-rAbs with pUL32, boosts of humoral immunity are triggered apparently by other CMV antigens than pUL32, like glycoprotein B.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic Lymphocytic Leukemia Patients Have a Preserved Cytomegalovirus-Specific Antibody Response despite Progressive Hypogammaglobulinemia

et al. 2013

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“…Let S t,i represent the number of susceptible individuals in city i at weekly timestep t . We reconstructed counts of susceptible individuals at timestep t +1 in city i as

where B t −16 .i are the number of births recorded in city i 16 weeks prior, because 3.8 months is the duration that infants born to non-vaccinated mothers retain maternal immunity against mumps ( Leuridan et al, 2012 ).…”

Section: Methodsmentioning

confidence: 99%