2015
DOI: 10.1016/j.physbeh.2015.05.040
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Maternal nicotine exposure during lactation alters food preference, anxiety-like behavior and the brain dopaminergic reward system in the adult rat offspring

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Cited by 25 publications
(11 citation statements)
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“…Decades of research on conventional cigarette smoke have reported the toxicological effects of smoking and nicotine on brain development. For example, studies utilizing various exposure paradigms to assess the developmental effects of prenatal and/or postnatal nicotine exposure in rodents reported increased hyperactivity (Lacy et al 2016;Newman et al 1999), impaired cognitive ability in terms of memory and attention, altered pre-pulse inhibition (Alkam et al 2013;Zhang et al 2018), and increased prevalence of anxiety-or depressive-like behaviors in adulthood (Lee et al 2016;Pinheiro et al 2015;Zhang et al 2019). Importantly, some of these behavioral alterations (e.g., increased activity) were reported in offspring of pregnant mice exposed to 2.4% nicotine through e-cigarette aerosol exposure (Smith et al 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Decades of research on conventional cigarette smoke have reported the toxicological effects of smoking and nicotine on brain development. For example, studies utilizing various exposure paradigms to assess the developmental effects of prenatal and/or postnatal nicotine exposure in rodents reported increased hyperactivity (Lacy et al 2016;Newman et al 1999), impaired cognitive ability in terms of memory and attention, altered pre-pulse inhibition (Alkam et al 2013;Zhang et al 2018), and increased prevalence of anxiety-or depressive-like behaviors in adulthood (Lee et al 2016;Pinheiro et al 2015;Zhang et al 2019). Importantly, some of these behavioral alterations (e.g., increased activity) were reported in offspring of pregnant mice exposed to 2.4% nicotine through e-cigarette aerosol exposure (Smith et al 2015).…”
Section: Introductionmentioning
confidence: 99%
“…84 Also, these males show a higher preference for a high-sugar content diet than controls. 85 Concerning females, we have recently shown that these animals, despite having normal body mass, show reduced nAChRs as well as leptin resistance in the hypothalamus, suggesting a central inflammatory process, as observed in nicotineexposed males. 86 A limitation of the current study is that we have not assessed α7nAchR in the hypothalamus and adipose tissue.…”
Section: Discussionmentioning
confidence: 93%
“…In agreement with results obtained in previous studies that used the same experimental model (Lima et al, 2010;Marcelino et al, 2004;Montanha-Rojas et al, 2005;Rocha et al, 2014), a significant loss in body mass was observed at P10 in the lactating dams that were subjected to the protein-free diet. Because Wistar rats have previously been shown to readily accept fat-and carbohydrate-rich chows and that chow consumption corrected for body mass is not significantly affected in our model (Pinheiro, Moura, Manhães, Fraga, Claudio-Neto, Abreu-Villaça, et al, 2015;Pinheiro, Moura, Manhães, Fraga, Claudio-Neto, Younes-Rapozo, et al, 2015), a likely explanation for this finding is the recourse, by the PFD dams, to endogenous reserves of amino acids (Woodside, Budin, Wellman, & Abizaid, 2012) in a physiological response to attempt to properly sustain the offspring. This possibility notwithstanding, the protein-free diet resulted in a significant reduction in the protein content of the milk produced by the undernourished dams, in line with previous reports that used a less severe protein restriction (Fukuda, Françolin-Silva, Hernandes, Valadares, & Almeida, 2007;Grigor et al, 1987;Pine, Jessop, & .0 (.0) .0 (.0) 1.5 (3.0)…”
Section: Body Mass Milk Content Maternal Behavior and Corticosterone ...mentioning
confidence: 85%