Maternal nutritional restriction during late gestation impairs development of the reproductive organs in both male and female lambs

Hoffman, Fredric; Boretto, E.; Vitale, Salvatore Giovanni; González, Verónica; Vidal, Gabriela Pereira; Pardo, M.F.; Flores, Marina; García, F. D.; Bagnis, Guillermo; Queiroz, O.C.M.; Rabaglino, María Belén

doi:10.1016/j.theriogenology.2017.12.023

Cited by 23 publications

(16 citation statements)

References 34 publications

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“…Experimental animal models of nutritional restriction programming reproduction in females Given the considerable amount of evidence from studies suggesting that reproductive function is influenced by early life events, particularly those that restrict fetal growth, animal models of nutrient restriction and FGR have been developed to understand underlying mechanisms. Using rodents models of maternal caloric restriction during pregnancy and/or lactation, we (Sloboda et al 2009, Bernal et al 2010, Chan et al 2015a, 2018, Jazwiec et al 2019) and others (Caron et al 2012, Mossa et al 2013, Khorram et al 2015, Hoffman et al 2018 have demonstrated that offspring born under conditions of nutrient restriction show early puberty, reproductive cycle irregularity and reductions in follicle subpopulations; clear indicators of early ovarian aging. Although some models of maternal caloric restriction have found that pubertal onset is delayed in female offspring (Engelbregt et al 2000, Sanchez-Garrido et al 2013, Matsuzaki et al 2018.…”

Section: Fgr and Maternal Nutritional Restrictionmentioning

confidence: 69%

“…Indeed, early studies in sheep have shown that an acute bout of undernutrition early in pregnancy impacts fetal follicular development where undernutrition during the first 30 days (of 150-day pregnancy) impaired growth of ovarian follicles in fetuses some 80 days later (Rae et al 2001). Undernutrition late in pregnancy resulted in smaller ovarian follicles in juvenile lambs possibly due to lower insulin like growth factor (IGF) levels (Hoffman et al 2018) and undernutrition throughout most of pregnancy resulted in a diminished response to GnRH in young lambs (Deligeorgis et al 1996). Undernutrition for the first half of pregnancy had no effect on FSH profiles in females, basal LH profiles or gonadotrophin responses to GnRH, but ovulation rate was significantly reduced (Rae et al 2002a).…”

Section: Fgr and Maternal Nutritional Restrictionmentioning

confidence: 99%

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Nutritional adversity, sex and reproduction: 30 years of DOHaD and what have we learned?

Jazwiec

Sloboda

2019

Journal of Endocrinology

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It is well established that early life environmental signals, including nutrition, set the stage for long-term health and disease risk – effects that span multiple generations. This relationship begins early, in the periconceptional period and extends into embryonic, fetal and early infant phases of life. Now known as the Developmental Origins of Health and Disease (DOHaD), this concept describes the adaptations that a developing organism makes in response to early life cues, resulting in adjustments in homeostatic systems that may prove maladaptive in postnatal life, leading to an increased risk of chronic disease and/or the inheritance of risk factors across generations. Reproductive maturation and function is similarly influenced by early life events. This should not be surprising, since primordial germ cells are established early in life and thus vulnerable to early life adversity. A multitude of ‘modifying’ cues inducing developmental adaptations have been identified that result in changes in reproductive development and impairments in reproductive function. Many types of nutritional challenges including caloric restriction, macronutrient excess and micronutrient insufficiencies have been shown to induce early life adaptations that produce long-term reproductive dysfunction. Many pathways have been suggested to underpin these associations, including epigenetic reprogramming of germ cells. While the mechanisms still remain to be fully investigated, it is clear that a lifecourse approach to understanding lifetime reproductive function is necessary. Furthermore, investigations of the impacts of early life adversity must be extended to include the paternal environment, especially in epidemiological and clinical studies of offspring reproductive function.

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Section: Fgr and Maternal Nutritional Restrictionmentioning

confidence: 69%

Section: Fgr and Maternal Nutritional Restrictionmentioning

confidence: 99%

Nutritional adversity, sex and reproduction: 30 years of DOHaD and what have we learned?

Jazwiec

Sloboda

2019

Journal of Endocrinology

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“…However, a number of studies have focused on the determination of the requirement of a specific race, considering that there is a nutritional difference between them (Ji et al, 2015;Pereira et al, 2017Pereira et al, , 2016Rodrigues et al, 2016). Certain researchers have worked on the effect of maternal nutritional requirement on progeny; these studies are called fetal programming, and are not usually studied in prediction equations (Campion et al, 2016;Hoffman et al, 2018;McGovern et al, 2015;Peine et al, 2018;Roca Fraga et al, 2018). Further investigation is warranted if the adjustments proposed in equations 5 and 6 would still apply to different levels of the plane of nutrition of gestating ewes.…”

Section: Resultsmentioning

confidence: 99%

Developing a continuous adjustment factor for dry matter intake of gestating and lactating ewes

Gallo

Tedeschi

2021

Sci. agric. (Piracicaba, Braz.)

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Intake is a multifactorial process that is influenced by animal type, environmental factors, and diet characteristics. Sheep, especially, have specific eating habits, with a greater selection of ingested feed compared to cattle. Thus, predictive equations for dry matter intake (DMI) must constantly be reviewed. The objective of this study was to combine different adjustment factors to develop one continuous adjustment factor for predicting the DMI of pregnant, dry, and lactating ewes. The equations evaluated for non-lactation ewes accounts for metabolic body weight and weight gain, and the equation for lactating ewes includes milk production and its fat content. The database used in this study was pooled from hair sheep ewes, two to four years old, with controlled feeding, during the pregnancy and lactating physiological phases. For the overall predictions (gestating and lactating ewes), the adjusted DMI prediction had greater accuracy but lower precision than the unadjusted DMI prediction. However, adjusting DMI increased the adequacy of the prediction as the mean square error of prediction difference (ΔMSEP) decreased (p = 0.0328). Similarly, for gestating ewes, the adjusted predicted DMI had a lower ΔMSEP than the unadjusted predicted DMI (p < 0.001). For lactating ewes, no difference was detected between the adjusted and unadjusted predicted DMI based on the ΔMSEP statistics (p = 0.3672), but the assumption that peak milk was 28 days (default) worsened the predictability of the adjusted predicted DMI as it had lower precision and accuracy. Adjustments for predicted DMI of dry and lactating ewes are necessary to increase adequacy and precision.

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“…To estimate the number of Sertoli and germ cells, 74 circular seminiferous tubules were analyzed on average per lamb. Cells with basal, leptochromatic (lax chromatin), ovoid, or pyriform nuclei were considered Sertoli cells, whereas non‐Sertoli cells were considerd germ cells (Hoffman et al, ; Wrobel, Bickel, Kujat, & Schimmel, ).…”

Section: Methodsmentioning

confidence: 99%

Testicular development in male lambs prenatally exposed to a high‐starch diet

Mossa

Bebbere

Ledda

et al. 2018

Molecular Reproduction Devel

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Maternal nutrition during critical gestation periods impacts on offspring in later life; effects of high-starch maternal diet on testicular development in lambs were addressed. Dairy ewes were fed diets providing either 27% (Starch, S) or 11% (Fiber, F) of starch from mating to lambing (∼147 days; S147, F147) or for the last 75 days of gestation (S75, F75). Testes of single male lambs were measured and then sampled for histological and gene expression analyses at selected ages. Testicular dimensions and weight were similar among groups, but the total area of seminiferous tubules increased with age and tended to be higher (p = 0.057) in lambs from starch- than fiber-fed ewes. Sertoli and germ cells number increased with age, but was not influenced by maternal diet. Transcript abundances of androgen receptor (AR), insulin-like growth factor 1 (IGF1), and hydroxysteroid (17-beta) dehydrogenase 3 (HSD17B3) was similar between S147 and F147 lambs (p > 0.1). Abundance of luteinizing hormone/choriogonadotropin receptor (LHCGR) and steroidogenic acute regulatory protein (STAR) was higher in young vs older lambs, whereas insulin-like growth factor 2 (IGF2) levels increased with age. The expression of vascular endothelial growth factor A (VEGFA), Anti-Müllerian hormone (AMH), IGF1, follicle stimulating hormone receptor (FSHR), and insulin-like growth factor 2 receptor (IGF2R) was not influenced by maternal diet or lamb age (p > 0.1). In conclusion, a high-starch maternal diet did not influence gene expression, but may have affected testicular structure in infant offspring, as seen by an increase in the total area of seminiferous tubules.

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Maternal nutritional restriction during late gestation impairs development of the reproductive organs in both male and female lambs

Cited by 23 publications

References 34 publications

Nutritional adversity, sex and reproduction: 30 years of DOHaD and what have we learned?

Nutritional adversity, sex and reproduction: 30 years of DOHaD and what have we learned?

Developing a continuous adjustment factor for dry matter intake of gestating and lactating ewes

Testicular development in male lambs prenatally exposed to a high‐starch diet

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