Maternal Obesity as a Risk Factor for Brain Development and Mental Health in the Offspring

Cirulli, Francesca; Musillo, Chiara; Berry, Alessandra

doi:10.1016/j.neuroscience.2020.01.023

Cited by 67 publications

(48 citation statements)

References 157 publications

(216 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The obtained results reflect the programming influence of obesity of both parents on the skeletal system of their offspring. In the literature, the most frequently described relationships on organogenesis and metabolism of the offspring are that of maternal obesity or of significant changes in nutrition in the period preceding or during pregnancy [44]. Studies of the impact of father obesity on offspring programming effects are not numerous, but they confirm the existence of such a relationship.…”

Section: Discussionmentioning

confidence: 99%

Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day

Radzki

Bieńko

Wolski

et al. 2021

Animals

View full text Add to dashboard Cite

Our study aimed to verify the hypothesis of the existence of a programming effect of parental obesity on the growth, development and mineralization of the skeletal system in female and male rat offspring on the day of weaning. The study began with the induction of obesity in female and male rats of the parental generation, using a high-energy diet (group F). Females and males of the control group received the standard diet (group S). After 90 days of dietary-induced obesity, the diet in group F was changed into the standard. Rats from groups F and S were mated to obtain offspring which stayed with their mothers until 21 days of age. Tibia was tested using dual-energy X-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT), micro-computed tomography (µCT) and mechanical strength using the three-point bending test. Biochemical analysis of blood serum bone metabolism markers was performed. DXA analysis showed higher tibia bone mineral content (BMC) and area. pQCT measurements of cortical and trabecular tissue documented the increase of the volumetric bone mineral density and BMC of both bone compartments in offspring from the F group, while µCT of the trabecular tissue showed an increase in trabecular thickness and a decrease of its separation. Parental obesity, hence, exerts a programming influence on the development of the skeletal system of the offspring on the day of the weaning, which was reflected in the intensification of mineralization and increased bone strength.

show abstract

Section: Discussionmentioning

confidence: 99%

Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day

Radzki

Bieńko

Wolski

et al. 2021

Animals

View full text Add to dashboard Cite

show abstract

“…Neurological/behavioral outcomes. As previously reviewed 118,121,122 , many animal studies provide evidence for epigenetic and long-term neurodevelopmental and behavioral consequences of maternal prenatal stress 172 , nutrition, obesity 173 , and other exposures 174 in the developing offspring. Other studies suggest that paternal exposures can alter offspring neurodevelopment, potentially through epigenetic changes in sperm 172,[175][176][177][178][179] .…”

Section: Rationale For Epigenetic Effectsmentioning

confidence: 99%

Exploring the evidence for epigenetic regulation of environmental influences on child health across generations

et al. 2021

View full text Add to dashboard Cite

Environmental exposures, psychosocial stressors and nutrition are all potentially important influences that may impact health outcomes directly or via interactions with the genome or epigenome over generations. While there have been clear successes in large-scale human genetic studies in recent decades, there is still a substantial amount of missing heritability to be elucidated for complex childhood disorders. Mounting evidence, primarily in animals, suggests environmental exposures may generate or perpetuate altered health outcomes across one or more generations. One putative mechanism for these environmental health effects is via altered epigenetic regulation. This review highlights the current epidemiologic literature and supporting animal studies that describe intergenerational and transgenerational health effects of environmental exposures. Both maternal and paternal exposures and transmission patterns are considered, with attention paid to the attendant ethical, legal and social implications.

show abstract

“…Thus, the earlier the intervention (also through specific diets and physical exercise) the greater the chance to prevent the decay in mental and physical health ( right panel ). Figure adapted with permission from [ 150 ], Copyright © 2015 Christensen and Pike, and from [ 136 , 159 ]: © 2007 Springer International Publishing and © 2020 Published by Elsevier Ltd on behalf of IBRO.…”

Section: Figurementioning

confidence: 99%

Curcuma Longa, the “Golden Spice” to Counteract Neuroinflammaging and Cognitive Decline—What Have We Learned and What Needs to Be Done

et al. 2021

Self Cite

View full text Add to dashboard Cite

Due to the global increase in lifespan, the proportion of people showing cognitive impairment is expected to grow exponentially. As target-specific drugs capable of tackling dementia are lagging behind, the focus of preclinical and clinical research has recently shifted towards natural products. Curcumin, one of the best investigated botanical constituents in the biomedical literature, has been receiving increased interest due to its unique molecular structure, which targets inflammatory and antioxidant pathways. These pathways have been shown to be critical for neurodegenerative disorders such as Alzheimer’s disease and more in general for cognitive decline. Despite the substantial preclinical literature on the potential biomedical effects of curcumin, its relatively low bioavailability, poor water solubility and rapid metabolism/excretion have hampered clinical trials, resulting in mixed and inconclusive findings. In this review, we highlight current knowledge on the potential effects of this natural compound on cognition. Furthermore, we focus on new strategies to overcome current limitations in its use and improve its efficacy, with attention also on gender-driven differences.

show abstract

Maternal Obesity as a Risk Factor for Brain Development and Mental Health in the Offspring

Cited by 67 publications

References 157 publications

Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day

Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day

Exploring the evidence for epigenetic regulation of environmental influences on child health across generations

Curcuma Longa, the “Golden Spice” to Counteract Neuroinflammaging and Cognitive Decline—What Have We Learned and What Needs to Be Done

Contact Info

Product

Resources

About