Maternal Obesity as a Risk Factor for the Development of Total Anomalous Pulmonary Venous Connection in Their Offspring

Alvarado-Terrones, Evelyn G.; Perea-Cabrera, Maryangel; Klünder-Klünder, Miguel; Segura-Stanford, Begoña; Erdmenger-Orellana, Julio; Blanco, Arturo Lopez-Yañez; Hernández-Carbajal, Elizabeth; Riverón, Javier T. Granados; Mejía-Marin, L.J.; Balderrabano-Saucedo, Norma; Contreras-Ramos, Alejandra; Diaz-Rosas, Guadalupe; Sánchez-Urbina, Rocío

doi:10.1016/j.arcmed.2018.06.001

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…A small case control study by Alvarado-Terrones et al. ( 22 ), investigating maternal factors associated with incidence of total anomalous pulmonary venous connection (TAPVC) presented findings consistent with these observations. This study included 55 mother-child cases with isolated TAPVC and 152 healthy mother-child cases.…”

Section: Resultsmentioning

confidence: 52%

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The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review

Kankowski¹,

Ardissino

McCracken

et al. 2022

Front. Endocrinol.

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ObjectiveObesity and cardiovascular disease are major global public health problems. Maternal obesity has been linked to multiple adverse health consequences for both mother and baby. Obesity during pregnancy may adversely alter the intrauterine environment, which has been hypothesised to predispose the offspring to poorer cardiovascular health throughout life. In this paper, we systematically review current literature examining the links between maternal obesity and offspring cardiovascular health.MethodsThis study is registered with PROSPERO (CRD42021278567) and was conducted in accordance with the PRISMA guidelines. A comprehensive systematic literature search was conducted, including two electronic databases (Ovid Medline, Embase), cross-referencing, author searching, and grey literature searches. We selected studies exploring the relationship between maternal obesity and offspring cardiovascular health, using pre-defined eligibility criteria. Studies were critically appraised using the ROBINS-I tool.ResultsFrom 1,214 results, 27 articles met the eligibility criteria. Multiple cardiovascular outcomes were considered, including congenital heart disease, cardiometabolic parameters, and cardiovascular diseases in neonates, children, and adults. In these studies, maternal obesity was consistently associated with congenital heart disease, several adverse cardiometabolic parameters throughout life including higher body mass index and insulin levels, and greater risk of cardiovascular disease in adulthood. Hypothesized underlying mechanisms are complex and multifactorial comprising genetic, environmental, and socioeconomic components, which can be difficult to quantify. Heterogeneity in study designs, highly selected study samples, and high risk of bias in some studies limit conclusions regarding causality.ConclusionsWe identified consistent evidence of links between maternal obesity and poorer offspring cardiovascular health throughout the lifecourse, extending from the neonatal period into adulthood. Although underlying mechanisms are unclear, our findings support consideration of targeted maternal obesity prevention for promotion of offspring cardiovascular health. This all-encompassing systematic review provides critical appraisal of the latest evidence, defines gaps and biases of existing literature, and may inform potential new public health strategies for cardiovascular disease prevention.Systematic Review Registration[https://www.crd.york.ac.uk/prospero], identifier PROSPERO (CRD42021278567).

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Section: Resultsmentioning

confidence: 52%

“…Maternal BMI was extracted from medical records and categorised into WHO obesity groups. In contrast with previously mentioned studied ( 22 , 24 , 26 ), Ghaderian et al. ( 25 ) report no statistically significant association between maternal obesity and infant CHD.…”

Section: Resultsmentioning

confidence: 61%

The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review

Kankowski¹,

Ardissino

McCracken

et al. 2022

Front. Endocrinol.

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“…Across the current analysis of CHDs and our previous analysis of maternal influenza vaccination and non‐CHDs using NBDPS data (Palmsten et al, 2022 ), only the adjusted CIs for simple TAPVR excluded the null. The biologic plausibility of this association is unclear (Alvarado‐Terrones et al, 2018 ). Based on the number of comparisons from our CHD and non‐CHD analyses (i.e., 29 overall), we expected one or two statistically significant associations due to chance.…”

Section: Discussionmentioning

confidence: 99%

Influenza vaccination during pregnancy and risk of selected major structural congenital heart defects, National Birth Defects Prevention Study 2006–2011

Palmsten

Suhl

Conway

et al. 2022

Birth Defects Research

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Background: Although results from studies of first-trimester influenza vaccination and congenital heart defects (CHDs) have been reassuring, data are limited for specific CHDs. Methods: We assessed associations between reported maternal influenza vaccination, 1 month before pregnancy (B1) through end of third pregnancy month (P3), and specific CHDs using data from a multisite, population-based case-control study. Analysis included 2,982 case children diagnosed with a simple CHD (no other cardiac involvement with or without extracardiac defects) and 4,937 control children without a birth defect with estimated delivery dates during 2006-2011. For defects with ≥5 exposed case children, we used logistic regression to estimate propensity score-adjusted odds ratios (aORs) and 95% confidence intervals (CIs), adjusting for estimated delivery

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“…We considered the covariates during the adjustment for confounders; maternal age at birth, birth year, premature birth, medical history of epilepsy, diabetes, obesity, and the use of teratogenic drugs in the first trimester of pregnancy. These covariates were defined on the basis of previous papers ( Eriksson et al, 2000 ; Ive et al, 2013 ; Minakami et al, 2014 ; Alvarado-Terrones et al, 2018 ; Trefz et al, 2018 ; Mbizvo et al, 2020 ). These covariates were considered a cause of exposure, of outcome, or of both or a proxy for an unmeasured factor.…”

Section: Methodsmentioning

confidence: 99%

No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study

Suzuki

Obara²,

Ishikawa³

et al. 2023

Front. Pharmacol.

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Traditional Japanese (Kampo) medicines containing rhubarb rhizome are prescribed for constipation during pregnancy; however, detailed safety information of their use for pregnant women is lacking. The aim of current study was to clarify the association between prescription Kampo-containing rhubarb rhizome (KRR) in the first trimester of pregnancy and congenital malformations in newborns. Using a large Japanese health insurance claims database, we included pregnant women who enrolled the same health insurance society from 3 months before pregnancy to the delivery date, who gave birth between 2010 and 2019, and those with data related to their infants. Pregnant women who were prescribed magnesium oxide (MgO), commonly used for constipation, during the first trimester of pregnancy and their infants were extracted as controls. Associations between KRR prescribed in the first pregnancy trimester and major congenital malformations (MCM) in the infants were examined using multivariate logistic regression analysis. Of 75,398 infants, 4,607 (6.1%) were diagnosed with MCMs within the first year after birth. Furthermore, 9,852 infants were born to women prescribed MgO, among whom 680 (6.9%) had MCMs; 450 infants were born to women prescribed KRR, among whom 28 (6.2%) had MCMs. Multivariate logistic regression analysis identified no difference in MCM risk between the two types of prescriptions [crude odds ratio (OR) 0.895, 95% confidence interval (CI) 0.606–1.322, adjusted OR 0.889, 95% CI 0.599–1.320]. In conclusion, the risk of MCMs did not differ between those prescribed KRR or MgO in the first trimester of pregnancy.

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Maternal Obesity as a Risk Factor for the Development of Total Anomalous Pulmonary Venous Connection in Their Offspring

Cited by 9 publications

References 43 publications

The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review

The Impact of Maternal Obesity on Offspring Cardiovascular Health: A Systematic Literature Review

Influenza vaccination during pregnancy and risk of selected major structural congenital heart defects, National Birth Defects Prevention Study 2006–2011

No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study

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